Coupling between transcription and alternative splicing
The scenario of alternative splicing regulation is far more complex than the classical picture of a pre-mRNA being processed post-transcriptionally in more than one way. Introns are efficiently removed while transcripts are still being synthesized, supporting the idea of a co-transcriptional regulat...
Guardado en:
Autores principales: | , , , |
---|---|
Formato: | SER |
Materias: | |
Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_09273042_v158_n_p1_Schor |
Aporte de: |
id |
todo:paper_09273042_v158_n_p1_Schor |
---|---|
record_format |
dspace |
spelling |
todo:paper_09273042_v158_n_p1_Schor2023-10-03T15:46:55Z Coupling between transcription and alternative splicing Schor, I.E. Gómez Acuña, L.I. Kornblihtt, A.R. Wu J.Y. Alternative splicing Chromatin Co-transcriptional splicing Kinetic model RNA polymerase II-CTD Transcription-splicing coupling RNA polymerase II chromatin RNA polymerase II RNA precursor alternative RNA splicing article cancer genetics carboxy terminal sequence chemical reaction kinetics chromatin structure exon gene expression histone methylation human intracellular signaling intron molecular interaction molecular model nonhuman priority journal protein secondary structure RNA translation transcription elongation transcription regulation chromatin genetic transcription RNA splicing Alternative Splicing Chromatin Humans RNA Polymerase II RNA Precursors RNA Splicing Transcription, Genetic The scenario of alternative splicing regulation is far more complex than the classical picture of a pre-mRNA being processed post-transcriptionally in more than one way. Introns are efficiently removed while transcripts are still being synthesized, supporting the idea of a co-transcriptional regulation of alternative splicing. Evidence of a functional coupling between splicing and transcription has recently emerged as it was observed that properties of one process may affect the outcome of the other. Co-transcriptionality is thought to improve splicing efficiency and kinetics by directing the nascent pre-mRNA into proper spliceosome assembly and favoring splicing factor recruitment. Two models have been proposed to explain the coupling of transcription and alternative splicing: in the recruitment model, promoters and pol II status affect the recruitment to the transcribing gene of splicing factors or bifunctional factors acting on both transcription and splicing; in the kinetic model, differences in the elongation rate of pol II would determine the timing in which splicing sites are presented, and thus the outcome of alternative splicing decisions. In the later model, chromatin structure has emerged as a key regulator. Although definitive evidence for transcriptionally coupled alternative splicing alterations in tumor development or cancer pathogenesis is still missing, many alternative splicing events altered in cancer might be subject to transcription-splicing coupling regulation. © Springer-Verlag Berlin Heidelberg 2013. SER info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_09273042_v158_n_p1_Schor |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Alternative splicing Chromatin Co-transcriptional splicing Kinetic model RNA polymerase II-CTD Transcription-splicing coupling RNA polymerase II chromatin RNA polymerase II RNA precursor alternative RNA splicing article cancer genetics carboxy terminal sequence chemical reaction kinetics chromatin structure exon gene expression histone methylation human intracellular signaling intron molecular interaction molecular model nonhuman priority journal protein secondary structure RNA translation transcription elongation transcription regulation chromatin genetic transcription RNA splicing Alternative Splicing Chromatin Humans RNA Polymerase II RNA Precursors RNA Splicing Transcription, Genetic |
spellingShingle |
Alternative splicing Chromatin Co-transcriptional splicing Kinetic model RNA polymerase II-CTD Transcription-splicing coupling RNA polymerase II chromatin RNA polymerase II RNA precursor alternative RNA splicing article cancer genetics carboxy terminal sequence chemical reaction kinetics chromatin structure exon gene expression histone methylation human intracellular signaling intron molecular interaction molecular model nonhuman priority journal protein secondary structure RNA translation transcription elongation transcription regulation chromatin genetic transcription RNA splicing Alternative Splicing Chromatin Humans RNA Polymerase II RNA Precursors RNA Splicing Transcription, Genetic Schor, I.E. Gómez Acuña, L.I. Kornblihtt, A.R. Wu J.Y. Coupling between transcription and alternative splicing |
topic_facet |
Alternative splicing Chromatin Co-transcriptional splicing Kinetic model RNA polymerase II-CTD Transcription-splicing coupling RNA polymerase II chromatin RNA polymerase II RNA precursor alternative RNA splicing article cancer genetics carboxy terminal sequence chemical reaction kinetics chromatin structure exon gene expression histone methylation human intracellular signaling intron molecular interaction molecular model nonhuman priority journal protein secondary structure RNA translation transcription elongation transcription regulation chromatin genetic transcription RNA splicing Alternative Splicing Chromatin Humans RNA Polymerase II RNA Precursors RNA Splicing Transcription, Genetic |
description |
The scenario of alternative splicing regulation is far more complex than the classical picture of a pre-mRNA being processed post-transcriptionally in more than one way. Introns are efficiently removed while transcripts are still being synthesized, supporting the idea of a co-transcriptional regulation of alternative splicing. Evidence of a functional coupling between splicing and transcription has recently emerged as it was observed that properties of one process may affect the outcome of the other. Co-transcriptionality is thought to improve splicing efficiency and kinetics by directing the nascent pre-mRNA into proper spliceosome assembly and favoring splicing factor recruitment. Two models have been proposed to explain the coupling of transcription and alternative splicing: in the recruitment model, promoters and pol II status affect the recruitment to the transcribing gene of splicing factors or bifunctional factors acting on both transcription and splicing; in the kinetic model, differences in the elongation rate of pol II would determine the timing in which splicing sites are presented, and thus the outcome of alternative splicing decisions. In the later model, chromatin structure has emerged as a key regulator. Although definitive evidence for transcriptionally coupled alternative splicing alterations in tumor development or cancer pathogenesis is still missing, many alternative splicing events altered in cancer might be subject to transcription-splicing coupling regulation. © Springer-Verlag Berlin Heidelberg 2013. |
format |
SER |
author |
Schor, I.E. Gómez Acuña, L.I. Kornblihtt, A.R. Wu J.Y. |
author_facet |
Schor, I.E. Gómez Acuña, L.I. Kornblihtt, A.R. Wu J.Y. |
author_sort |
Schor, I.E. |
title |
Coupling between transcription and alternative splicing |
title_short |
Coupling between transcription and alternative splicing |
title_full |
Coupling between transcription and alternative splicing |
title_fullStr |
Coupling between transcription and alternative splicing |
title_full_unstemmed |
Coupling between transcription and alternative splicing |
title_sort |
coupling between transcription and alternative splicing |
url |
http://hdl.handle.net/20.500.12110/paper_09273042_v158_n_p1_Schor |
work_keys_str_mv |
AT schorie couplingbetweentranscriptionandalternativesplicing AT gomezacunali couplingbetweentranscriptionandalternativesplicing AT kornblihttar couplingbetweentranscriptionandalternativesplicing AT wujy couplingbetweentranscriptionandalternativesplicing |
_version_ |
1782023741635559424 |