Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation

Cochlear outer hair cells (OHCs) express α9 nACh receptors and are contacted by descending, predominately cholinergic, efferent fibers originating in the CNS. Mice carrying a null mutation for the nACh α9 gene were produced to investigate its role(s) in auditory processing and development of hair ce...

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Detalles Bibliográficos
Autores principales: Vetter, D.E., Liberman, M.C., Mann, J., Barhanin, J., Boulter, J., Brown, M.C., Saffiote-Kolman, J., Heinemann, S.F., Elgoyhen, A.B.
Formato: JOUR
Materias:
nicotinic receptor
receptor subunit
animal tissue
article
cell maturation
cell structure
cochlea
controlled study
Corti organ
distortion product otoacoustic emission
efferent nerve
gene structure
gene targeting
hair cell
knockout mouse
male
nonhuman
nucleotide sequence
parasympathetic innervation
priority journal
animal
cytology
genetics
growth, development and aging
innervation
mouse
mouse mutant
olivary nucleus
physiology
Animals
Cochlea
Efferent Pathways
Hair Cells, Outer
Mice
Mice, Knockout
Olivary Nucleus
Receptors, Nicotinic
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_08966273_v23_n1_p93_Vetter
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Cochlear outer hair cells (OHCs) express α9 nACh receptors and are contacted by descending, predominately cholinergic, efferent fibers originating in the CNS. Mice carrying a null mutation for the nACh α9 gene were produced to investigate its role(s) in auditory processing and development of hair cell innervation. In α9 knockout mice, most OHCs were innervated by one large terminal instead of multiple smaller terminals as in wild types, suggesting a role for the nACh α9 subunit in development of mature synaptic connections. α9 knockout mice also failed to show suppression of cochlear responses (compound action potentials, distortion product otoacoustic emissions) during efferent fiber activation, demonstrating the key role α9 receptors play in mediating the only known effects of the olivocochlear system.

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