Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation
Cochlear outer hair cells (OHCs) express α9 nACh receptors and are contacted by descending, predominately cholinergic, efferent fibers originating in the CNS. Mice carrying a null mutation for the nACh α9 gene were produced to investigate its role(s) in auditory processing and development of hair ce...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_08966273_v23_n1_p93_Vetter |
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todo:paper_08966273_v23_n1_p93_Vetter2023-10-03T15:43:45Z Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation Vetter, D.E. Liberman, M.C. Mann, J. Barhanin, J. Boulter, J. Brown, M.C. Saffiote-Kolman, J. Heinemann, S.F. Elgoyhen, A.B. nicotinic receptor receptor subunit nicotinic receptor animal tissue article cell maturation cell structure cochlea controlled study Corti organ distortion product otoacoustic emission efferent nerve gene structure gene targeting hair cell knockout mouse male nonhuman nucleotide sequence parasympathetic innervation priority journal animal cytology genetics growth, development and aging innervation mouse mouse mutant olivary nucleus physiology Animals Cochlea Efferent Pathways Hair Cells, Outer Mice Mice, Knockout Olivary Nucleus Receptors, Nicotinic Cochlear outer hair cells (OHCs) express α9 nACh receptors and are contacted by descending, predominately cholinergic, efferent fibers originating in the CNS. Mice carrying a null mutation for the nACh α9 gene were produced to investigate its role(s) in auditory processing and development of hair cell innervation. In α9 knockout mice, most OHCs were innervated by one large terminal instead of multiple smaller terminals as in wild types, suggesting a role for the nACh α9 subunit in development of mature synaptic connections. α9 knockout mice also failed to show suppression of cochlear responses (compound action potentials, distortion product otoacoustic emissions) during efferent fiber activation, demonstrating the key role α9 receptors play in mediating the only known effects of the olivocochlear system. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_08966273_v23_n1_p93_Vetter |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
nicotinic receptor receptor subunit nicotinic receptor animal tissue article cell maturation cell structure cochlea controlled study Corti organ distortion product otoacoustic emission efferent nerve gene structure gene targeting hair cell knockout mouse male nonhuman nucleotide sequence parasympathetic innervation priority journal animal cytology genetics growth, development and aging innervation mouse mouse mutant olivary nucleus physiology Animals Cochlea Efferent Pathways Hair Cells, Outer Mice Mice, Knockout Olivary Nucleus Receptors, Nicotinic |
| spellingShingle |
nicotinic receptor receptor subunit nicotinic receptor animal tissue article cell maturation cell structure cochlea controlled study Corti organ distortion product otoacoustic emission efferent nerve gene structure gene targeting hair cell knockout mouse male nonhuman nucleotide sequence parasympathetic innervation priority journal animal cytology genetics growth, development and aging innervation mouse mouse mutant olivary nucleus physiology Animals Cochlea Efferent Pathways Hair Cells, Outer Mice Mice, Knockout Olivary Nucleus Receptors, Nicotinic Vetter, D.E. Liberman, M.C. Mann, J. Barhanin, J. Boulter, J. Brown, M.C. Saffiote-Kolman, J. Heinemann, S.F. Elgoyhen, A.B. Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation |
| topic_facet |
nicotinic receptor receptor subunit nicotinic receptor animal tissue article cell maturation cell structure cochlea controlled study Corti organ distortion product otoacoustic emission efferent nerve gene structure gene targeting hair cell knockout mouse male nonhuman nucleotide sequence parasympathetic innervation priority journal animal cytology genetics growth, development and aging innervation mouse mouse mutant olivary nucleus physiology Animals Cochlea Efferent Pathways Hair Cells, Outer Mice Mice, Knockout Olivary Nucleus Receptors, Nicotinic |
| description |
Cochlear outer hair cells (OHCs) express α9 nACh receptors and are contacted by descending, predominately cholinergic, efferent fibers originating in the CNS. Mice carrying a null mutation for the nACh α9 gene were produced to investigate its role(s) in auditory processing and development of hair cell innervation. In α9 knockout mice, most OHCs were innervated by one large terminal instead of multiple smaller terminals as in wild types, suggesting a role for the nACh α9 subunit in development of mature synaptic connections. α9 knockout mice also failed to show suppression of cochlear responses (compound action potentials, distortion product otoacoustic emissions) during efferent fiber activation, demonstrating the key role α9 receptors play in mediating the only known effects of the olivocochlear system. |
| format |
JOUR |
| author |
Vetter, D.E. Liberman, M.C. Mann, J. Barhanin, J. Boulter, J. Brown, M.C. Saffiote-Kolman, J. Heinemann, S.F. Elgoyhen, A.B. |
| author_facet |
Vetter, D.E. Liberman, M.C. Mann, J. Barhanin, J. Boulter, J. Brown, M.C. Saffiote-Kolman, J. Heinemann, S.F. Elgoyhen, A.B. |
| author_sort |
Vetter, D.E. |
| title |
Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation |
| title_short |
Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation |
| title_full |
Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation |
| title_fullStr |
Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation |
| title_full_unstemmed |
Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation |
| title_sort |
role of α9 nicotinic ach receptor subunits in the development and function of cochlear efferent innervation |
| url |
http://hdl.handle.net/20.500.12110/paper_08966273_v23_n1_p93_Vetter |
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