Effects of Progesterone on oligodendrocyte progenitors, oligodendrocyte transcription factors, and myelin proteins following spinal cord injury

Progesterone is emerging as a myelinizing factor for central nervous system injury. Successful remyelination requires proliferation and differentiation of oligodendrocyte precursor cells (OPC) into myelinating oligodendrocytes, but this process is incomplete following injury. To study progesterone a...

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Detalles Bibliográficos
Autores principales:	Labombarda, F., González, S.L., Lima, A., Roig, P., Guennoun, R., Schumacher, M., De Nicola, A.F.
Formato:	JOUR
Materias:	NG2 cells Nkx2.2 Olig1 Olig2 Remyelination Steroids Trauma broxuridine messenger RNA myelin basic protein myelin oligodendrocyte glycoprotein myelin protein nucleic acid binding protein oligodendrocyte transcription factor 1 oligodendrocyte transcription factor 2 progesterone proteolipid protein transcription factor transcription factor Nkx2.2 unclassified drug basic helix loop helix transcription factor gestagen homeodomain protein myelin associated glycoprotein nerve protein Nkx 2.2 homedomain protein Nkx-2.2 homedomain protein Olig1 protein, rat oligodendrocyte myelin glycoprotein oligodendrocyte-myelin glycoprotein Plp1 protein, rat animal cell animal experiment animal model article cell count cell density cell function cell lineage cell proliferation cell specificity chronic drug administration controlled study demyelination down regulation drug mechanism early intervention gene expression regulation hormone action male nerve cell differentiation neural stem cell nonhuman nucleotide sequence oligodendroglia priority journal protein expression protein function rat remyelinization short course therapy spinal cord injury upregulation adult stem cell animal disease model drug effect genetics metabolism methodology orchiectomy Sprague Dawley rat time Adult Stem Cells Animals Basic Helix-Loop-Helix Transcription Factors Disease Models, Animal Gene Expression Regulation Homeodomain Proteins Male Myelin Proteins Myelin Proteolipid Protein Myelin-Associated Glycoprotein Nerve Tissue Proteins Oligodendroglia Orchiectomy Progesterone Progestins Rats Rats, Sprague-Dawley RNA, Messenger Spinal Cord Injuries Time Factors Transcription Factors
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_08941491_v57_n8_p884_Labombarda
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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