Aerobic fermentation of glucose by trypanosomatids
The consumption of glucose by trypanosomatid protozoa such as Trypanosoma brucei, Trypanosoma cruzi, Leishmania spp., and Crithidia spp. is characterized by the excretion of reduced products such as succinate, pyruvate, ethanol, L-alanine, or lactate (depending on the species) not only in anaerobios...
Guardado en:
| Autor principal: | |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_08926638_v6_n13_p3153_Cazzulo |
| Aporte de: |
| id |
todo:paper_08926638_v6_n13_p3153_Cazzulo |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_08926638_v6_n13_p3153_Cazzulo2023-10-03T15:41:37Z Aerobic fermentation of glucose by trypanosomatids Cazzulo, J.-J. anaerobic carbohydrate glucose catabolism glycolytic enzymes leishmanias Pasteur effect amino acid glucose malic acid reduced nicotinamide adenine dinucleotide enzyme activity fermentation glucose utilization glycolysis leishmania nonhuman oxidation priority journal protein degradation review trypanosoma brucei trypanosoma cruzi Aerobiosis Amino Acids Animal Carbohydrates Fermentation Glucose NAD Support, Non-U.S. Gov't Trypanosomatina Crithidia Protozoa Trypanosoma Trypanosoma brucei Trypanosoma cruzi Trypanosomatidae The consumption of glucose by trypanosomatid protozoa such as Trypanosoma brucei, Trypanosoma cruzi, Leishmania spp., and Crithidia spp. is characterized by the excretion of reduced products such as succinate, pyruvate, ethanol, L-alanine, or lactate (depending on the species) not only in anaerobiosis, but also under aerobic conditions. The 'aerobic fermentation' of glucose is accompanied by a complete lack, or even a reversal, of the Pasteur effect. This peculiar catabolism is mediated by a so-far unique compartmentation of the glycolytic enzymes, most of which are placed in an organelle called the glycosome; by an almost complete lack of inhibitory controls at the level of hexokinase and phosphofructokinase; and by a central role of CO2 fixation through the reaction catalyzed by phosphoenolpyruvate carboxykinase. The production of fermentative products seems to be due to a relative inefficiency of the respiratory chain, which lacks NADH dehydrogenase and the first phosphorylation site and preferentially uses succinate as substrate. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_08926638_v6_n13_p3153_Cazzulo |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
anaerobic carbohydrate glucose catabolism glycolytic enzymes leishmanias Pasteur effect amino acid glucose malic acid reduced nicotinamide adenine dinucleotide enzyme activity fermentation glucose utilization glycolysis leishmania nonhuman oxidation priority journal protein degradation review trypanosoma brucei trypanosoma cruzi Aerobiosis Amino Acids Animal Carbohydrates Fermentation Glucose NAD Support, Non-U.S. Gov't Trypanosomatina Crithidia Protozoa Trypanosoma Trypanosoma brucei Trypanosoma cruzi Trypanosomatidae |
| spellingShingle |
anaerobic carbohydrate glucose catabolism glycolytic enzymes leishmanias Pasteur effect amino acid glucose malic acid reduced nicotinamide adenine dinucleotide enzyme activity fermentation glucose utilization glycolysis leishmania nonhuman oxidation priority journal protein degradation review trypanosoma brucei trypanosoma cruzi Aerobiosis Amino Acids Animal Carbohydrates Fermentation Glucose NAD Support, Non-U.S. Gov't Trypanosomatina Crithidia Protozoa Trypanosoma Trypanosoma brucei Trypanosoma cruzi Trypanosomatidae Cazzulo, J.-J. Aerobic fermentation of glucose by trypanosomatids |
| topic_facet |
anaerobic carbohydrate glucose catabolism glycolytic enzymes leishmanias Pasteur effect amino acid glucose malic acid reduced nicotinamide adenine dinucleotide enzyme activity fermentation glucose utilization glycolysis leishmania nonhuman oxidation priority journal protein degradation review trypanosoma brucei trypanosoma cruzi Aerobiosis Amino Acids Animal Carbohydrates Fermentation Glucose NAD Support, Non-U.S. Gov't Trypanosomatina Crithidia Protozoa Trypanosoma Trypanosoma brucei Trypanosoma cruzi Trypanosomatidae |
| description |
The consumption of glucose by trypanosomatid protozoa such as Trypanosoma brucei, Trypanosoma cruzi, Leishmania spp., and Crithidia spp. is characterized by the excretion of reduced products such as succinate, pyruvate, ethanol, L-alanine, or lactate (depending on the species) not only in anaerobiosis, but also under aerobic conditions. The 'aerobic fermentation' of glucose is accompanied by a complete lack, or even a reversal, of the Pasteur effect. This peculiar catabolism is mediated by a so-far unique compartmentation of the glycolytic enzymes, most of which are placed in an organelle called the glycosome; by an almost complete lack of inhibitory controls at the level of hexokinase and phosphofructokinase; and by a central role of CO2 fixation through the reaction catalyzed by phosphoenolpyruvate carboxykinase. The production of fermentative products seems to be due to a relative inefficiency of the respiratory chain, which lacks NADH dehydrogenase and the first phosphorylation site and preferentially uses succinate as substrate. |
| format |
JOUR |
| author |
Cazzulo, J.-J. |
| author_facet |
Cazzulo, J.-J. |
| author_sort |
Cazzulo, J.-J. |
| title |
Aerobic fermentation of glucose by trypanosomatids |
| title_short |
Aerobic fermentation of glucose by trypanosomatids |
| title_full |
Aerobic fermentation of glucose by trypanosomatids |
| title_fullStr |
Aerobic fermentation of glucose by trypanosomatids |
| title_full_unstemmed |
Aerobic fermentation of glucose by trypanosomatids |
| title_sort |
aerobic fermentation of glucose by trypanosomatids |
| url |
http://hdl.handle.net/20.500.12110/paper_08926638_v6_n13_p3153_Cazzulo |
| work_keys_str_mv |
AT cazzulojj aerobicfermentationofglucosebytrypanosomatids |
| _version_ |
1807322055057604608 |