Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior
TGF-β1 is an anti-inflammatory cytokine that is augmented in the brain of autistic patients and that can affect brain development. In this work, we studied the effects of overexpressing TGF-β1 in the dentate gyrus of adult or young mice on behavior. TGF-β1 overexpression during postnatal development...
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todo:paper_08891591_v25_n8_p1582_Depino2023-10-03T15:41:11Z Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior Depino, A.M. Lucchina, L. Pitossi, F. Autism Behavior Mice Neuroinflammation Postnatal programming Transforming Growth Factor-beta 1 interleukin 6 neuroligin reelin transforming growth factor beta1 animal experiment article behavior compulsion controlled study dentate gyrus depression gene overexpression grooming hippocampus male mouse nerve cell nonhuman priority journal protein expression social interaction Adenoviridae Animals Behavior, Animal Depression Female Gliosis Grooming Hindlimb Suspension Hippocampus Immunohistochemistry Interpersonal Relations Male Mice Mice, Inbred C57BL Mice, Transgenic Pregnancy Real-Time Polymerase Chain Reaction RNA, Messenger Stereotaxic Techniques Swimming Transforming Growth Factor beta1 TGF-β1 is an anti-inflammatory cytokine that is augmented in the brain of autistic patients and that can affect brain development. In this work, we studied the effects of overexpressing TGF-β1 in the dentate gyrus of adult or young mice on behavior. TGF-β1 overexpression during postnatal development led to a long-term decrease in social interaction and to long-term increases in self-grooming and depression-related behaviors. Our analysis shows that these behavioral changes correlate with the long-term downregulation of TGF-β1 and IL-6 expression in the dentate gyrus, as well as to decreases in the mRNA levels of the synaptic protein neuroligin 3 and in the number of Reelin-positive neurons in the dentate gyrus. In contrast, chronic expression of TGF-β1 during adulthood led to transient opposite effects on these behaviors. These results show a central role of hippocampal TGF-β1 in the programming and modulation of social interaction, repetitive behavior and depression-related behavior. Finally, our data suggest a role of hippocampal TGF-β1 and early-life neuroinflammation in the development of the behavioral alterations observed in autism spectrum disorders. © 2011 Elsevier Inc. Fil:Depino, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Lucchina, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_08891591_v25_n8_p1582_Depino |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Autism Behavior Mice Neuroinflammation Postnatal programming Transforming Growth Factor-beta 1 interleukin 6 neuroligin reelin transforming growth factor beta1 animal experiment article behavior compulsion controlled study dentate gyrus depression gene overexpression grooming hippocampus male mouse nerve cell nonhuman priority journal protein expression social interaction Adenoviridae Animals Behavior, Animal Depression Female Gliosis Grooming Hindlimb Suspension Hippocampus Immunohistochemistry Interpersonal Relations Male Mice Mice, Inbred C57BL Mice, Transgenic Pregnancy Real-Time Polymerase Chain Reaction RNA, Messenger Stereotaxic Techniques Swimming Transforming Growth Factor beta1 |
| spellingShingle |
Autism Behavior Mice Neuroinflammation Postnatal programming Transforming Growth Factor-beta 1 interleukin 6 neuroligin reelin transforming growth factor beta1 animal experiment article behavior compulsion controlled study dentate gyrus depression gene overexpression grooming hippocampus male mouse nerve cell nonhuman priority journal protein expression social interaction Adenoviridae Animals Behavior, Animal Depression Female Gliosis Grooming Hindlimb Suspension Hippocampus Immunohistochemistry Interpersonal Relations Male Mice Mice, Inbred C57BL Mice, Transgenic Pregnancy Real-Time Polymerase Chain Reaction RNA, Messenger Stereotaxic Techniques Swimming Transforming Growth Factor beta1 Depino, A.M. Lucchina, L. Pitossi, F. Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior |
| topic_facet |
Autism Behavior Mice Neuroinflammation Postnatal programming Transforming Growth Factor-beta 1 interleukin 6 neuroligin reelin transforming growth factor beta1 animal experiment article behavior compulsion controlled study dentate gyrus depression gene overexpression grooming hippocampus male mouse nerve cell nonhuman priority journal protein expression social interaction Adenoviridae Animals Behavior, Animal Depression Female Gliosis Grooming Hindlimb Suspension Hippocampus Immunohistochemistry Interpersonal Relations Male Mice Mice, Inbred C57BL Mice, Transgenic Pregnancy Real-Time Polymerase Chain Reaction RNA, Messenger Stereotaxic Techniques Swimming Transforming Growth Factor beta1 |
| description |
TGF-β1 is an anti-inflammatory cytokine that is augmented in the brain of autistic patients and that can affect brain development. In this work, we studied the effects of overexpressing TGF-β1 in the dentate gyrus of adult or young mice on behavior. TGF-β1 overexpression during postnatal development led to a long-term decrease in social interaction and to long-term increases in self-grooming and depression-related behaviors. Our analysis shows that these behavioral changes correlate with the long-term downregulation of TGF-β1 and IL-6 expression in the dentate gyrus, as well as to decreases in the mRNA levels of the synaptic protein neuroligin 3 and in the number of Reelin-positive neurons in the dentate gyrus. In contrast, chronic expression of TGF-β1 during adulthood led to transient opposite effects on these behaviors. These results show a central role of hippocampal TGF-β1 in the programming and modulation of social interaction, repetitive behavior and depression-related behavior. Finally, our data suggest a role of hippocampal TGF-β1 and early-life neuroinflammation in the development of the behavioral alterations observed in autism spectrum disorders. © 2011 Elsevier Inc. |
| format |
JOUR |
| author |
Depino, A.M. Lucchina, L. Pitossi, F. |
| author_facet |
Depino, A.M. Lucchina, L. Pitossi, F. |
| author_sort |
Depino, A.M. |
| title |
Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior |
| title_short |
Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior |
| title_full |
Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior |
| title_fullStr |
Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior |
| title_full_unstemmed |
Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior |
| title_sort |
early and adult hippocampal tgf-β1 overexpression have opposite effects on behavior |
| url |
http://hdl.handle.net/20.500.12110/paper_08891591_v25_n8_p1582_Depino |
| work_keys_str_mv |
AT depinoam earlyandadulthippocampaltgfb1overexpressionhaveoppositeeffectsonbehavior AT lucchinal earlyandadulthippocampaltgfb1overexpressionhaveoppositeeffectsonbehavior AT pitossif earlyandadulthippocampaltgfb1overexpressionhaveoppositeeffectsonbehavior |
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1807316285164355584 |