Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats
The relationships between exercise and metabolites as well as between exercise and sarcoplasmic reticulum function were studied in gastrocnemius muscle of ovariectomized-trained rats. Prolonged moderate-intensity exercise, treadmill up-hill run for 90 min with a 10° incline, decreased the muscle gly...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_08628408_v51_n3_p247_Gigli |
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todo:paper_08628408_v51_n3_p247_Gigli2023-10-03T15:40:18Z Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats Gigli, I. Bussmann, L.E. Exercise Muscle fatigue Rats Sarcoplasmic reticulum adenosine triphosphatase adenosine triphosphate aspartate aminotransferase calcium ion creatine kinase glucose 6 phosphate glycogen silver adenosine triphosphatase (calcium magnesium) adenosine triphosphate calcium creatine phosphate glucose 6 phosphate glycogen lactic acid sex hormone aerobic metabolism animal experiment animal tissue article calcium transport controlled study energy metabolism enzyme activity exercise exhaustion female gastrocnemius muscle glycogen muscle level membrane vesicle metabolite muscle fatigue muscle metabolism nonhuman ovariectomy rat sarcoplasmic reticulum tissue homogenate treadmill exercise animal metabolism physiology skeletal muscle Sprague Dawley rat Adenosine Triphosphate Animal Ca(2+) Mg(2+)-ATPase Calcium Exertion Female Glucose-6-Phosphate Glycogen Lactic Acid Muscle Fatigue Muscle, Skeletal Ovariectomy Phosphocreatine Rats Rats, Sprague-Dawley Sarcoplasmic Reticulum Sex Hormones Support, Non-U.S. Gov't Animals Exertion Gonadal Steroid Hormones Muscle, Skeletal Sarcoplasmic Reticulum The relationships between exercise and metabolites as well as between exercise and sarcoplasmic reticulum function were studied in gastrocnemius muscle of ovariectomized-trained rats. Prolonged moderate-intensity exercise, treadmill up-hill run for 90 min with a 10° incline, decreased the muscle glycogen content. Exercise until exhaustion further lowered the glycogen concentration to 13 % of the control, together with a significant decrease of ATP and glucose-6-phosphate concentrations. Also, Ag+-induced Ca2+release, measured in whole muscle homogenate, showed a 30 % reduction on exhaustion, while Ca2+ uptake was unaffected by this exercise. ATPase activities, of both homogenate and SR vesicles, and Ca2+ transport in the latter preparation were not altered on exhaustion. It could be concluded from these results that muscular fatigue in ovariectomized rats after aerobic exercise is caused by the change in energy supply and Ca2+ release from the SR, this latter possibly due to metabolites generated by the exercise. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_08628408_v51_n3_p247_Gigli |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Exercise Muscle fatigue Rats Sarcoplasmic reticulum adenosine triphosphatase adenosine triphosphate aspartate aminotransferase calcium ion creatine kinase glucose 6 phosphate glycogen silver adenosine triphosphatase (calcium magnesium) adenosine triphosphate calcium creatine phosphate glucose 6 phosphate glycogen lactic acid sex hormone aerobic metabolism animal experiment animal tissue article calcium transport controlled study energy metabolism enzyme activity exercise exhaustion female gastrocnemius muscle glycogen muscle level membrane vesicle metabolite muscle fatigue muscle metabolism nonhuman ovariectomy rat sarcoplasmic reticulum tissue homogenate treadmill exercise animal metabolism physiology skeletal muscle Sprague Dawley rat Adenosine Triphosphate Animal Ca(2+) Mg(2+)-ATPase Calcium Exertion Female Glucose-6-Phosphate Glycogen Lactic Acid Muscle Fatigue Muscle, Skeletal Ovariectomy Phosphocreatine Rats Rats, Sprague-Dawley Sarcoplasmic Reticulum Sex Hormones Support, Non-U.S. Gov't Animals Exertion Gonadal Steroid Hormones Muscle, Skeletal Sarcoplasmic Reticulum |
| spellingShingle |
Exercise Muscle fatigue Rats Sarcoplasmic reticulum adenosine triphosphatase adenosine triphosphate aspartate aminotransferase calcium ion creatine kinase glucose 6 phosphate glycogen silver adenosine triphosphatase (calcium magnesium) adenosine triphosphate calcium creatine phosphate glucose 6 phosphate glycogen lactic acid sex hormone aerobic metabolism animal experiment animal tissue article calcium transport controlled study energy metabolism enzyme activity exercise exhaustion female gastrocnemius muscle glycogen muscle level membrane vesicle metabolite muscle fatigue muscle metabolism nonhuman ovariectomy rat sarcoplasmic reticulum tissue homogenate treadmill exercise animal metabolism physiology skeletal muscle Sprague Dawley rat Adenosine Triphosphate Animal Ca(2+) Mg(2+)-ATPase Calcium Exertion Female Glucose-6-Phosphate Glycogen Lactic Acid Muscle Fatigue Muscle, Skeletal Ovariectomy Phosphocreatine Rats Rats, Sprague-Dawley Sarcoplasmic Reticulum Sex Hormones Support, Non-U.S. Gov't Animals Exertion Gonadal Steroid Hormones Muscle, Skeletal Sarcoplasmic Reticulum Gigli, I. Bussmann, L.E. Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats |
| topic_facet |
Exercise Muscle fatigue Rats Sarcoplasmic reticulum adenosine triphosphatase adenosine triphosphate aspartate aminotransferase calcium ion creatine kinase glucose 6 phosphate glycogen silver adenosine triphosphatase (calcium magnesium) adenosine triphosphate calcium creatine phosphate glucose 6 phosphate glycogen lactic acid sex hormone aerobic metabolism animal experiment animal tissue article calcium transport controlled study energy metabolism enzyme activity exercise exhaustion female gastrocnemius muscle glycogen muscle level membrane vesicle metabolite muscle fatigue muscle metabolism nonhuman ovariectomy rat sarcoplasmic reticulum tissue homogenate treadmill exercise animal metabolism physiology skeletal muscle Sprague Dawley rat Adenosine Triphosphate Animal Ca(2+) Mg(2+)-ATPase Calcium Exertion Female Glucose-6-Phosphate Glycogen Lactic Acid Muscle Fatigue Muscle, Skeletal Ovariectomy Phosphocreatine Rats Rats, Sprague-Dawley Sarcoplasmic Reticulum Sex Hormones Support, Non-U.S. Gov't Animals Exertion Gonadal Steroid Hormones Muscle, Skeletal Sarcoplasmic Reticulum |
| description |
The relationships between exercise and metabolites as well as between exercise and sarcoplasmic reticulum function were studied in gastrocnemius muscle of ovariectomized-trained rats. Prolonged moderate-intensity exercise, treadmill up-hill run for 90 min with a 10° incline, decreased the muscle glycogen content. Exercise until exhaustion further lowered the glycogen concentration to 13 % of the control, together with a significant decrease of ATP and glucose-6-phosphate concentrations. Also, Ag+-induced Ca2+release, measured in whole muscle homogenate, showed a 30 % reduction on exhaustion, while Ca2+ uptake was unaffected by this exercise. ATPase activities, of both homogenate and SR vesicles, and Ca2+ transport in the latter preparation were not altered on exhaustion. It could be concluded from these results that muscular fatigue in ovariectomized rats after aerobic exercise is caused by the change in energy supply and Ca2+ release from the SR, this latter possibly due to metabolites generated by the exercise. |
| format |
JOUR |
| author |
Gigli, I. Bussmann, L.E. |
| author_facet |
Gigli, I. Bussmann, L.E. |
| author_sort |
Gigli, I. |
| title |
Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats |
| title_short |
Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats |
| title_full |
Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats |
| title_fullStr |
Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats |
| title_full_unstemmed |
Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats |
| title_sort |
effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats |
| url |
http://hdl.handle.net/20.500.12110/paper_08628408_v51_n3_p247_Gigli |
| work_keys_str_mv |
AT giglii effectsofexerciseonmusclemetabolitesandsarcoplasmicreticulumfunctioninovariectomizedrats AT bussmannle effectsofexerciseonmusclemetabolitesandsarcoplasmicreticulumfunctioninovariectomizedrats |
| _version_ |
1807321358668922880 |