Cortisol: A tool to study aldosterone biosynthesis in rats

Corticosterone (B) and 18-hydroxy-11-deoxycorticosterone (18OHDOC) but not 11-deoxycorticosterone (DOC) displaced cortisol (F) specifically bound to rat adrenal mitochondria. F competitively inhibited aldosterone formation from B, 18OHB and 18OHDOC but did not inhibit conversions of DOC to B or 18OH...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Matkovic, L., Gomez-sanchez, C.E., Lantos, C.P., Cozza, E.N.
Formato: JOUR
Materias:
18 hydroxydeoxycorticosterone
aldosterone
corticosterone
cytochrome p450
deoxycorticosterone
hydrocortisone
steroid 11beta monooxygenase
adrenal cortex
animal tissue
conference paper
controlled study
enzyme activity
enzyme substrate
male
mitochondrion
nonhuman
priority journal
rat
steroidogenesis
18-Hydroxydesoxycorticosterone
Adrenal Glands
Aldosterone
Animal
Binding, Competitive
Corticosterone
Hydrocortisone
Male
Mitochondria
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S.
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_07435800_v21_n1-2_p471_Matkovic
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_07435800_v21_n1-2_p471_Matkovic
record_format dspace
spelling todo:paper_07435800_v21_n1-2_p471_Matkovic2023-10-03T15:38:28Z Cortisol: A tool to study aldosterone biosynthesis in rats Matkovic, L. Gomez-sanchez, C.E. Lantos, C.P. Cozza, E.N. 18 hydroxydeoxycorticosterone aldosterone corticosterone cytochrome p450 deoxycorticosterone hydrocortisone steroid 11beta monooxygenase adrenal cortex animal tissue conference paper controlled study enzyme activity enzyme substrate male mitochondrion nonhuman priority journal rat steroidogenesis 18-Hydroxydesoxycorticosterone Adrenal Glands Aldosterone Animal Binding, Competitive Corticosterone Hydrocortisone Male Mitochondria Rats Rats, Inbred Strains Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Corticosterone (B) and 18-hydroxy-11-deoxycorticosterone (18OHDOC) but not 11-deoxycorticosterone (DOC) displaced cortisol (F) specifically bound to rat adrenal mitochondria. F competitively inhibited aldosterone formation from B, 18OHB and 18OHDOC but did not inhibit conversions of DOC to B or 18OHDOC. High concentrations of DOC increased its conversion to 18OHDOC rather than B. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_07435800_v21_n1-2_p471_Matkovic
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic 18 hydroxydeoxycorticosterone
aldosterone
corticosterone
cytochrome p450
deoxycorticosterone
hydrocortisone
steroid 11beta monooxygenase
adrenal cortex
animal tissue
conference paper
controlled study
enzyme activity
enzyme substrate
male
mitochondrion
nonhuman
priority journal
rat
steroidogenesis
18-Hydroxydesoxycorticosterone
Adrenal Glands
Aldosterone
Animal
Binding, Competitive
Corticosterone
Hydrocortisone
Male
Mitochondria
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S.
spellingShingle 18 hydroxydeoxycorticosterone
aldosterone
corticosterone
cytochrome p450
deoxycorticosterone
hydrocortisone
steroid 11beta monooxygenase
adrenal cortex
animal tissue
conference paper
controlled study
enzyme activity
enzyme substrate
male
mitochondrion
nonhuman
priority journal
rat
steroidogenesis
18-Hydroxydesoxycorticosterone
Adrenal Glands
Aldosterone
Animal
Binding, Competitive
Corticosterone
Hydrocortisone
Male
Mitochondria
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S.
Matkovic, L.
Gomez-sanchez, C.E.
Lantos, C.P.
Cozza, E.N.
Cortisol: A tool to study aldosterone biosynthesis in rats
topic_facet 18 hydroxydeoxycorticosterone
aldosterone
corticosterone
cytochrome p450
deoxycorticosterone
hydrocortisone
steroid 11beta monooxygenase
adrenal cortex
animal tissue
conference paper
controlled study
enzyme activity
enzyme substrate
male
mitochondrion
nonhuman
priority journal
rat
steroidogenesis
18-Hydroxydesoxycorticosterone
Adrenal Glands
Aldosterone
Animal
Binding, Competitive
Corticosterone
Hydrocortisone
Male
Mitochondria
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S.
description Corticosterone (B) and 18-hydroxy-11-deoxycorticosterone (18OHDOC) but not 11-deoxycorticosterone (DOC) displaced cortisol (F) specifically bound to rat adrenal mitochondria. F competitively inhibited aldosterone formation from B, 18OHB and 18OHDOC but did not inhibit conversions of DOC to B or 18OHDOC. High concentrations of DOC increased its conversion to 18OHDOC rather than B. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
format JOUR
author Matkovic, L.
Gomez-sanchez, C.E.
Lantos, C.P.
Cozza, E.N.
author_facet Matkovic, L.
Gomez-sanchez, C.E.
Lantos, C.P.
Cozza, E.N.
author_sort Matkovic, L.
title Cortisol: A tool to study aldosterone biosynthesis in rats
title_short Cortisol: A tool to study aldosterone biosynthesis in rats
title_full Cortisol: A tool to study aldosterone biosynthesis in rats
title_fullStr Cortisol: A tool to study aldosterone biosynthesis in rats
title_full_unstemmed Cortisol: A tool to study aldosterone biosynthesis in rats
title_sort cortisol: a tool to study aldosterone biosynthesis in rats
url http://hdl.handle.net/20.500.12110/paper_07435800_v21_n1-2_p471_Matkovic
work_keys_str_mv AT matkovicl cortisolatooltostudyaldosteronebiosynthesisinrats
AT gomezsanchezce cortisolatooltostudyaldosteronebiosynthesisinrats
AT lantoscp cortisolatooltostudyaldosteronebiosynthesisinrats
AT cozzaen cortisolatooltostudyaldosteronebiosynthesisinrats
_version_ 1807320466537316352

Ejemplares similares