Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo.

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1. Some studies of cyclophosphamide (CP) and its metabolite acrolein in chick embryo liver were carried out in order to investigate the mechanism of the porphyrinogenic action of CP. 2. In vitro and in vivo studies revealed that CP induced but did not activate delta-aminolaevulinic acid (ALA) syntha...

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Detalles Bibliográficos
Autores principales: Cochón, A.C., San Martín de Viale, L.C., Wainstok de Calmanovici, R.
Formato: JOUR
Lenguaje:English
Materias:
5 aminolevulinate synthase
acrolein
allylisopropylacetamide
cyclophosphamide
Cytochrome P 450 Enzyme System
cytochrome P450
phenobarbital
porphyrin
proadifen
animal
article
biosynthesis
chemical structure
chemistry
chick embryo
drug effect
enzyme induction
enzymology
gestational age
liver
metabolism
5-Aminolevulinate Synthetase
Acrolein
Allylisopropylacetamide
Animal
Chick Embryo
Cyclophosphamide
Cytochrome P-450 Enzyme System
Enzyme Induction
Gestational Age
Liver
Molecular Structure
Phenobarbital
Porphyrins
Proadifen
Support, Non-U.S. Gov't
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_07428413_v102_n1_p143_Cochon
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:1. Some studies of cyclophosphamide (CP) and its metabolite acrolein in chick embryo liver were carried out in order to investigate the mechanism of the porphyrinogenic action of CP. 2. In vitro and in vivo studies revealed that CP induced but did not activate delta-aminolaevulinic acid (ALA) synthase. 3. Pretreatments with phenobarbital (PB) or SKF-525A did not modify ALA-synthase induction produced by CP. 4. Acrolein administration neither induced ALA-synthase activity nor increased cytochrome P-450 content or led to hepatic porphyrin accumulation. 5. Time course induction of cytochrome P-450 content after administration of CP or PB was similar. 6. The results obtained would indicate that CP is a strong inducer of both ALA-synthase activity and microsomal cytochrome P-450 content in liver of 17 day-old chick embryos and that its porphyrinogenic activity is not mediated by its metabolite acrolein.

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