In vivo protection by melatonin against δ-aminolevulinic acid-induced oxidative damage and its antioxidant effect on the activity of haem enzymes

Accumulation of 8-aminolevulinic acid (ALA), as it occurs in acute intermittent porphyria, is a potential endogenous source of reactive oxygen species (ROS) which can then produce oxidative damage to cell structures and macromolecules. This in vivo study investigated whether melatonin could prevent...

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Detalles Bibliográficos
Autores principales: Princ, F.G., Maxit, A.G., Cardalda, C., Batlle, A., Juknat, A.A.
Formato: JOUR
Materias:
δ-aminolevulinate dehydratase
δ-aminolevulinic acid
Antioxidative enzymes
Melatonin
Porphobilinogen deaminase
Reactive oxygen species
aminolevulinic acid
antioxidant
melatonin
porphobilinogen deaminase
porphobilinogen synthase
animal experiment
animal tissue
article
brain cortex
brain injury
cerebellum
controlled study
intraperitoneal drug administration
lipid peroxidation
male
neuroprotection
nonhuman
oxidative stress
rat
Aminolevulinic Acid
Animals
Antioxidants
Cerebellum
Cerebral Cortex
Free Radical Scavengers
Hydroxymethylbilane Synthase
Injections, Intraperitoneal
Lipid Peroxidation
Male
Malondialdehyde
Oxidative Stress
Porphobilinogen Synthase
Rats
Reactive Oxygen Species
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_07423098_v24_n1_p1_Princ
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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