Intra-aneurysmal pressure after incomplete endovascular exclusion
Purpose: An endoleak results from the incomplete endovascular exclusion of an aneurysm. We developed an experimental model to analyze hemodynamic changes within the aneurysm sac in the presence of an endoleak, with and without a simulated open collateral branch. Methods: With a latex aneurysm model...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_07415214_v34_n5_p909_Parodi |
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todo:paper_07415214_v34_n5_p909_Parodi2023-10-03T15:38:19Z Intra-aneurysmal pressure after incomplete endovascular exclusion Parodi, J.C. Berguer, R. Ferreira, L.M. La Mura, R. Schermerhorn, M.L. aneurysm aneurysm rupture article biological model blood vessel transplantation human pathophysiology postoperative complication pressure Aneurysm Aneurysm, Ruptured Blood Vessel Prosthesis Implantation Humans Models, Cardiovascular Postoperative Complications Pressure Purpose: An endoleak results from the incomplete endovascular exclusion of an aneurysm. We developed an experimental model to analyze hemodynamic changes within the aneurysm sac in the presence of an endoleak, with and without a simulated open collateral branch. Methods: With a latex aneurysm model connected to a pulsatile pump, pressures were measured simultaneously within the system (systemic pressure) and the aneurysm sac (intrasac pressure). The experiments were performed without endoleak (control group) and after creating a 3.5-mm (group 1), 4.5-mm (group 2), and 6-mm (group 3) diameter orifice in the endograft, simulating an endoleak. Pressures were also registered with and without a patent aneurysm side branch. Results: In each endoleak group, the intrasac diastolic pressure (DP) and mean pressure (MP) were significantly higher than the systemic DP and MP (P = .01, P = .006, and P = .001, respectively), although the pressure curve was damped. The presence of an open side branch significantly reduced the intrasac DP and MP. Conclusion: In this model, intrasac pressures were significantly higher than systemic pressures in the presence of all endoleaks, even the smallest ones. Intrasac pressures higher than systemic pressure may pose a high risk for aneurysm rupture. Although patent side branches significantly reduce these pressures, the aggressive management of an endoleak should be pursued. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_07415214_v34_n5_p909_Parodi |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
aneurysm aneurysm rupture article biological model blood vessel transplantation human pathophysiology postoperative complication pressure Aneurysm Aneurysm, Ruptured Blood Vessel Prosthesis Implantation Humans Models, Cardiovascular Postoperative Complications Pressure |
| spellingShingle |
aneurysm aneurysm rupture article biological model blood vessel transplantation human pathophysiology postoperative complication pressure Aneurysm Aneurysm, Ruptured Blood Vessel Prosthesis Implantation Humans Models, Cardiovascular Postoperative Complications Pressure Parodi, J.C. Berguer, R. Ferreira, L.M. La Mura, R. Schermerhorn, M.L. Intra-aneurysmal pressure after incomplete endovascular exclusion |
| topic_facet |
aneurysm aneurysm rupture article biological model blood vessel transplantation human pathophysiology postoperative complication pressure Aneurysm Aneurysm, Ruptured Blood Vessel Prosthesis Implantation Humans Models, Cardiovascular Postoperative Complications Pressure |
| description |
Purpose: An endoleak results from the incomplete endovascular exclusion of an aneurysm. We developed an experimental model to analyze hemodynamic changes within the aneurysm sac in the presence of an endoleak, with and without a simulated open collateral branch. Methods: With a latex aneurysm model connected to a pulsatile pump, pressures were measured simultaneously within the system (systemic pressure) and the aneurysm sac (intrasac pressure). The experiments were performed without endoleak (control group) and after creating a 3.5-mm (group 1), 4.5-mm (group 2), and 6-mm (group 3) diameter orifice in the endograft, simulating an endoleak. Pressures were also registered with and without a patent aneurysm side branch. Results: In each endoleak group, the intrasac diastolic pressure (DP) and mean pressure (MP) were significantly higher than the systemic DP and MP (P = .01, P = .006, and P = .001, respectively), although the pressure curve was damped. The presence of an open side branch significantly reduced the intrasac DP and MP. Conclusion: In this model, intrasac pressures were significantly higher than systemic pressures in the presence of all endoleaks, even the smallest ones. Intrasac pressures higher than systemic pressure may pose a high risk for aneurysm rupture. Although patent side branches significantly reduce these pressures, the aggressive management of an endoleak should be pursued. |
| format |
JOUR |
| author |
Parodi, J.C. Berguer, R. Ferreira, L.M. La Mura, R. Schermerhorn, M.L. |
| author_facet |
Parodi, J.C. Berguer, R. Ferreira, L.M. La Mura, R. Schermerhorn, M.L. |
| author_sort |
Parodi, J.C. |
| title |
Intra-aneurysmal pressure after incomplete endovascular exclusion |
| title_short |
Intra-aneurysmal pressure after incomplete endovascular exclusion |
| title_full |
Intra-aneurysmal pressure after incomplete endovascular exclusion |
| title_fullStr |
Intra-aneurysmal pressure after incomplete endovascular exclusion |
| title_full_unstemmed |
Intra-aneurysmal pressure after incomplete endovascular exclusion |
| title_sort |
intra-aneurysmal pressure after incomplete endovascular exclusion |
| url |
http://hdl.handle.net/20.500.12110/paper_07415214_v34_n5_p909_Parodi |
| work_keys_str_mv |
AT parodijc intraaneurysmalpressureafterincompleteendovascularexclusion AT berguerr intraaneurysmalpressureafterincompleteendovascularexclusion AT ferreiralm intraaneurysmalpressureafterincompleteendovascularexclusion AT lamurar intraaneurysmalpressureafterincompleteendovascularexclusion AT schermerhornml intraaneurysmalpressureafterincompleteendovascularexclusion |
| _version_ |
1807316424853553152 |