Correlation of TGF-(si expression with medroxiprogesterone acetate responsiveness in mouse mammary adenocarcinomas
We investigated the expression of transforming growth factors β1 and α (TGF-β1, TGF-α in hormone-responsive (MPA-R) and unresponsive (MPA-U) tumor lines obtained from medroxyprogesterone acetate (MPA)-induced mammary adenocarcinomas in BALBIc mice. The tumors were transplanted into MPA-treated and u...
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todo:paper_07357907_v13_n2_p173_Elizalde2023-10-03T15:37:46Z Correlation of TGF-(si expression with medroxiprogesterone acetate responsiveness in mouse mammary adenocarcinomas Elizalde, P.V. Guerra, F.K. Gravano, M. Lanari, C. Lippman, M.E. Charreau, E.H. Lupu, R. medroxyprogesterone acetate transforming growth factor beta1 animal experiment animal model article breast carcinoma controlled study female mouse nonhuman priority journal Adenocarcinoma Animal Female Gene Expression Mammary Neoplasms, Experimental Medroxyprogesterone 17-Acetate Mice Mice, Inbred BALB C Neoplasm Transplantation Neoplasms, Hormone-Dependent Receptors, Estrogen Receptors, Progesterone Receptors, Transforming Growth Factor beta RNA, Messenger RNA, Neoplasm Support, Non-U.S. Gov't Transforming Growth Factor alpha Transforming Growth Factor beta Tumor Cells, Cultured We investigated the expression of transforming growth factors β1 and α (TGF-β1, TGF-α in hormone-responsive (MPA-R) and unresponsive (MPA-U) tumor lines obtained from medroxyprogesterone acetate (MPA)-induced mammary adenocarcinomas in BALBIc mice. The tumors were transplanted into MPA-treated and untreated mice. TGF-β1 gene expression was observed in the MPA-R lines growing in untreated animals, but not in MPA-treated mice. TGF-β1 mRNA was not detected in the MPA-U tumor lines growing in either MPA-treated or untreated animals. In MPA-R lines the levels of TGF-β1 expression were inversely correlated to growth rate. High-affinity TGF-β1 receptors were present in the MPA-R tumors. These results suggest that one of the mechanisms by which MP A exerts its proliferative effect on MPA-R tumor lines is inhibition of the expression of TGF-β1. Thus, the lack of expression of TGF-β1 in MPA-U tumors may be related to the acquisition of autonomous growth. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_07357907_v13_n2_p173_Elizalde |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
medroxyprogesterone acetate transforming growth factor beta1 animal experiment animal model article breast carcinoma controlled study female mouse nonhuman priority journal Adenocarcinoma Animal Female Gene Expression Mammary Neoplasms, Experimental Medroxyprogesterone 17-Acetate Mice Mice, Inbred BALB C Neoplasm Transplantation Neoplasms, Hormone-Dependent Receptors, Estrogen Receptors, Progesterone Receptors, Transforming Growth Factor beta RNA, Messenger RNA, Neoplasm Support, Non-U.S. Gov't Transforming Growth Factor alpha Transforming Growth Factor beta Tumor Cells, Cultured |
| spellingShingle |
medroxyprogesterone acetate transforming growth factor beta1 animal experiment animal model article breast carcinoma controlled study female mouse nonhuman priority journal Adenocarcinoma Animal Female Gene Expression Mammary Neoplasms, Experimental Medroxyprogesterone 17-Acetate Mice Mice, Inbred BALB C Neoplasm Transplantation Neoplasms, Hormone-Dependent Receptors, Estrogen Receptors, Progesterone Receptors, Transforming Growth Factor beta RNA, Messenger RNA, Neoplasm Support, Non-U.S. Gov't Transforming Growth Factor alpha Transforming Growth Factor beta Tumor Cells, Cultured Elizalde, P.V. Guerra, F.K. Gravano, M. Lanari, C. Lippman, M.E. Charreau, E.H. Lupu, R. Correlation of TGF-(si expression with medroxiprogesterone acetate responsiveness in mouse mammary adenocarcinomas |
| topic_facet |
medroxyprogesterone acetate transforming growth factor beta1 animal experiment animal model article breast carcinoma controlled study female mouse nonhuman priority journal Adenocarcinoma Animal Female Gene Expression Mammary Neoplasms, Experimental Medroxyprogesterone 17-Acetate Mice Mice, Inbred BALB C Neoplasm Transplantation Neoplasms, Hormone-Dependent Receptors, Estrogen Receptors, Progesterone Receptors, Transforming Growth Factor beta RNA, Messenger RNA, Neoplasm Support, Non-U.S. Gov't Transforming Growth Factor alpha Transforming Growth Factor beta Tumor Cells, Cultured |
| description |
We investigated the expression of transforming growth factors β1 and α (TGF-β1, TGF-α in hormone-responsive (MPA-R) and unresponsive (MPA-U) tumor lines obtained from medroxyprogesterone acetate (MPA)-induced mammary adenocarcinomas in BALBIc mice. The tumors were transplanted into MPA-treated and untreated mice. TGF-β1 gene expression was observed in the MPA-R lines growing in untreated animals, but not in MPA-treated mice. TGF-β1 mRNA was not detected in the MPA-U tumor lines growing in either MPA-treated or untreated animals. In MPA-R lines the levels of TGF-β1 expression were inversely correlated to growth rate. High-affinity TGF-β1 receptors were present in the MPA-R tumors. These results suggest that one of the mechanisms by which MP A exerts its proliferative effect on MPA-R tumor lines is inhibition of the expression of TGF-β1. Thus, the lack of expression of TGF-β1 in MPA-U tumors may be related to the acquisition of autonomous growth. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
| format |
JOUR |
| author |
Elizalde, P.V. Guerra, F.K. Gravano, M. Lanari, C. Lippman, M.E. Charreau, E.H. Lupu, R. |
| author_facet |
Elizalde, P.V. Guerra, F.K. Gravano, M. Lanari, C. Lippman, M.E. Charreau, E.H. Lupu, R. |
| author_sort |
Elizalde, P.V. |
| title |
Correlation of TGF-(si expression with medroxiprogesterone acetate responsiveness in mouse mammary adenocarcinomas |
| title_short |
Correlation of TGF-(si expression with medroxiprogesterone acetate responsiveness in mouse mammary adenocarcinomas |
| title_full |
Correlation of TGF-(si expression with medroxiprogesterone acetate responsiveness in mouse mammary adenocarcinomas |
| title_fullStr |
Correlation of TGF-(si expression with medroxiprogesterone acetate responsiveness in mouse mammary adenocarcinomas |
| title_full_unstemmed |
Correlation of TGF-(si expression with medroxiprogesterone acetate responsiveness in mouse mammary adenocarcinomas |
| title_sort |
correlation of tgf-(si expression with medroxiprogesterone acetate responsiveness in mouse mammary adenocarcinomas |
| url |
http://hdl.handle.net/20.500.12110/paper_07357907_v13_n2_p173_Elizalde |
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