Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster
Longevity is a typical quantitative trait which is influenced by multiple genes. Here we explore the genetic variation in longevity of Drosophila melanogaster in both mildly heat-stressed and control flies. Quantitative trait loci (QTL) analysis for longevity was performed in a single-sex environmen...
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todo:paper_05315565_v46_n10_p819_Defays2023-10-03T15:34:12Z Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster Defays, R. Gómez, F.H. Sambucetti, P. Scannapieco, A.C. Loeschcke, V. Norry, F.M. Hormesis Life span QTL Single-sex environment Thermal stress age distribution article controlled study Drosophila melanogaster environmental temperature female genetic analysis genetic variability heat stress hormesis insect genome lifespan longevity male nonhuman priority journal quantitative trait locus quantitative trait locus mapping recombinant inbred strain sex ratio temperature sensitivity Adaptation, Physiological Aging Animals Chromosome Mapping Drosophila melanogaster Gene Knockdown Techniques Genes, Insect Genetic Variation Heat-Shock Response Hot Temperature Longevity Quantitative Trait Loci Drosophila melanogaster Longevity is a typical quantitative trait which is influenced by multiple genes. Here we explore the genetic variation in longevity of Drosophila melanogaster in both mildly heat-stressed and control flies. Quantitative trait loci (QTL) analysis for longevity was performed in a single-sex environment at 25 °C with and without a mild heat-stress pre-treatment, using a previously reported set of recombinant inbred lines (RIL). QTL regions for longevity in heat-stressed flies overlapped with QTL for longevity in control flies. All longevity QTL co-localized with QTL for longevity identified in previous studies using very different sets of RIL in mixed sex environments, though the genome is nearly saturated with QTL for longevity when considering all previous studies. Heat stress decreased the number of significant QTL for longevity if compared to the control environment. Our mild heat-stress pre-treatment had a beneficial effect (hormesis) more often in shorter-lived than in longer-lived RIL. © 2011 Elsevier Inc. Fil:Defays, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gómez, F.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sambucetti, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Scannapieco, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Norry, F.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_05315565_v46_n10_p819_Defays |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Hormesis Life span QTL Single-sex environment Thermal stress age distribution article controlled study Drosophila melanogaster environmental temperature female genetic analysis genetic variability heat stress hormesis insect genome lifespan longevity male nonhuman priority journal quantitative trait locus quantitative trait locus mapping recombinant inbred strain sex ratio temperature sensitivity Adaptation, Physiological Aging Animals Chromosome Mapping Drosophila melanogaster Gene Knockdown Techniques Genes, Insect Genetic Variation Heat-Shock Response Hot Temperature Longevity Quantitative Trait Loci Drosophila melanogaster |
| spellingShingle |
Hormesis Life span QTL Single-sex environment Thermal stress age distribution article controlled study Drosophila melanogaster environmental temperature female genetic analysis genetic variability heat stress hormesis insect genome lifespan longevity male nonhuman priority journal quantitative trait locus quantitative trait locus mapping recombinant inbred strain sex ratio temperature sensitivity Adaptation, Physiological Aging Animals Chromosome Mapping Drosophila melanogaster Gene Knockdown Techniques Genes, Insect Genetic Variation Heat-Shock Response Hot Temperature Longevity Quantitative Trait Loci Drosophila melanogaster Defays, R. Gómez, F.H. Sambucetti, P. Scannapieco, A.C. Loeschcke, V. Norry, F.M. Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster |
| topic_facet |
Hormesis Life span QTL Single-sex environment Thermal stress age distribution article controlled study Drosophila melanogaster environmental temperature female genetic analysis genetic variability heat stress hormesis insect genome lifespan longevity male nonhuman priority journal quantitative trait locus quantitative trait locus mapping recombinant inbred strain sex ratio temperature sensitivity Adaptation, Physiological Aging Animals Chromosome Mapping Drosophila melanogaster Gene Knockdown Techniques Genes, Insect Genetic Variation Heat-Shock Response Hot Temperature Longevity Quantitative Trait Loci Drosophila melanogaster |
| description |
Longevity is a typical quantitative trait which is influenced by multiple genes. Here we explore the genetic variation in longevity of Drosophila melanogaster in both mildly heat-stressed and control flies. Quantitative trait loci (QTL) analysis for longevity was performed in a single-sex environment at 25 °C with and without a mild heat-stress pre-treatment, using a previously reported set of recombinant inbred lines (RIL). QTL regions for longevity in heat-stressed flies overlapped with QTL for longevity in control flies. All longevity QTL co-localized with QTL for longevity identified in previous studies using very different sets of RIL in mixed sex environments, though the genome is nearly saturated with QTL for longevity when considering all previous studies. Heat stress decreased the number of significant QTL for longevity if compared to the control environment. Our mild heat-stress pre-treatment had a beneficial effect (hormesis) more often in shorter-lived than in longer-lived RIL. © 2011 Elsevier Inc. |
| format |
JOUR |
| author |
Defays, R. Gómez, F.H. Sambucetti, P. Scannapieco, A.C. Loeschcke, V. Norry, F.M. |
| author_facet |
Defays, R. Gómez, F.H. Sambucetti, P. Scannapieco, A.C. Loeschcke, V. Norry, F.M. |
| author_sort |
Defays, R. |
| title |
Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster |
| title_short |
Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster |
| title_full |
Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster |
| title_fullStr |
Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster |
| title_full_unstemmed |
Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster |
| title_sort |
quantitative trait loci for longevity in heat-stressed drosophila melanogaster |
| url |
http://hdl.handle.net/20.500.12110/paper_05315565_v46_n10_p819_Defays |
| work_keys_str_mv |
AT defaysr quantitativetraitlociforlongevityinheatstresseddrosophilamelanogaster AT gomezfh quantitativetraitlociforlongevityinheatstresseddrosophilamelanogaster AT sambucettip quantitativetraitlociforlongevityinheatstresseddrosophilamelanogaster AT scannapiecoac quantitativetraitlociforlongevityinheatstresseddrosophilamelanogaster AT loeschckev quantitativetraitlociforlongevityinheatstresseddrosophilamelanogaster AT norryfm quantitativetraitlociforlongevityinheatstresseddrosophilamelanogaster |
| _version_ |
1807317498253541376 |