Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria

The role of thyroid status in hexachlorobenzene (HBC) induced porphyria was studied in normal, thyroidectomized and thyroxine (T4) treated rats. Female Wistar rats were treated with HCB for different periods of time. Serum T4 levels were depressed after 8 days of HCB administration whereas levels of...

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Detalles Bibliográficos
Autores principales: Sopena de Kracoff, Y.E., Ferramola de Sancovich, A.M., Sancovich, H.A., de Pisarev, D.L.K.
Formato: JOUR
Materias:
hexachlorobenzene
porphyria
porphyrinogen carboxy-liase
thyroid status
Thyroxine
liothyronine
thyrotropin
thyroxine
uroporphyrinogen decarboxylase
animal experiment
animal model
article
controlled study
enzyme activity
female
hyperthyroxinemia
liothyronine blood level
nonhuman
rat
thyroidectomy
thyrotropin blood level
thyroxine blood level
Animal
Carboxy-Lyases
Female
Hexachlorobenzene
Porphyria
Rats
Rats, Wistar
Support, Non-U.S. Gov't
Thyroidectomy
Triiodothyronine
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03914097_v17_n5_p301_SopenadeKracoff
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The role of thyroid status in hexachlorobenzene (HBC) induced porphyria was studied in normal, thyroidectomized and thyroxine (T4) treated rats. Female Wistar rats were treated with HCB for different periods of time. Serum T4 levels were depressed after 8 days of HCB administration whereas levels of triiodothyronine (T3) were not altered. T4 administered simultaneously with HCB resulted in hyperthyroxinemia. The time course of porphyrinogen carboxy-lyase (PCL) activity in the three HBC treated groups was studied. A rapid and significant decrease of PCL activity was found after 8 days of HCB treatment in T4 treated rats with respect to untreated animals. In contrast, HCB treatment of normal and thyroidectomized rats elicited a significant decrease of PCL activity after 21 and 30 days, respectively. This study shows that thyroid hormone plays an important role in the early establishment of HCB induced porphyria. © 1994, Italian Society of Endocrinology (SIE). All rights reserved.

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