Inhibitory and excitatory effects of iodobenzene on the antennal benzoic acid receptor cells of the female silk moth Bombyx mori L
As shown in single-sensillum recordings, iodobenzene has a bimodal effect on the receptor cell tuned to benzoic acid (BA) of the female silk moth Bombyx mor. Exposure to iodobenzene causes an inhibition of the response to BA. With stimulation by iodobenzene alone, a reduction of basic nerve impulse...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0379864X_v30_n5_p435_deBritoSanchez |
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todo:paper_0379864X_v30_n5_p435_deBritoSanchez2023-10-03T15:33:41Z Inhibitory and excitatory effects of iodobenzene on the antennal benzoic acid receptor cells of the female silk moth Bombyx mori L de Brito Sanchez, M.G. Kaissling, K.-E. Aniline Benzoic acid receptor cell Bombyx mori Inhibition Iodobenzene Olfactory receptor benzoic acid halide halogen iodine iodobenzene linalool action potential antenna article controlled study inhibition kinetics nerve cell stimulation nerve conduction nonhuman olfactory receptor priority journal rebound receptor binding receptor potential sensory system electrophysiology silkworm stimulus response Bombyx Bombyx mori As shown in single-sensillum recordings, iodobenzene has a bimodal effect on the receptor cell tuned to benzoic acid (BA) of the female silk moth Bombyx mor. Exposure to iodobenzene causes an inhibition of the response to BA. With stimulation by iodobenzene alone, a reduction of basic nerve impulse firing during exposure is followed by a transient post-stimulus excitation (rebound). We suggest that inhibition suppresses excitation during exposure but fades afterwards more rapidly than excitation. Due to the spatial equivalence of the iodine and the acid residue, these effects might indicate opposing interactions of iodobenzene with the specific site for the key compound BA. This is supported by the fact that substitutions by smaller halogens are less effective in both inhibition and rebound. The inhibitory effect but not the rebound with iodobenzene alone was also observed in receptor cells tuned to key compounds other than benzoic acid, e.g. in the cell most sensitive to 2,6-dimethyl-5-heptene-2-ol (DMH-cell) occurring in the same sensillum as the BA-cell, or in the bombykol- and bombykal-cells of the male. At least in these cells the inhibitory effect might reflect the action of iodobenzene on a general site, e.g. the lipid matrix of the plasma membrane of the receptor cells. © The Author 2005. Published by Oxford University Press. All rights reserved. Fil:de Brito Sanchez, M.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0379864X_v30_n5_p435_deBritoSanchez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Aniline Benzoic acid receptor cell Bombyx mori Inhibition Iodobenzene Olfactory receptor benzoic acid halide halogen iodine iodobenzene linalool action potential antenna article controlled study inhibition kinetics nerve cell stimulation nerve conduction nonhuman olfactory receptor priority journal rebound receptor binding receptor potential sensory system electrophysiology silkworm stimulus response Bombyx Bombyx mori |
| spellingShingle |
Aniline Benzoic acid receptor cell Bombyx mori Inhibition Iodobenzene Olfactory receptor benzoic acid halide halogen iodine iodobenzene linalool action potential antenna article controlled study inhibition kinetics nerve cell stimulation nerve conduction nonhuman olfactory receptor priority journal rebound receptor binding receptor potential sensory system electrophysiology silkworm stimulus response Bombyx Bombyx mori de Brito Sanchez, M.G. Kaissling, K.-E. Inhibitory and excitatory effects of iodobenzene on the antennal benzoic acid receptor cells of the female silk moth Bombyx mori L |
| topic_facet |
Aniline Benzoic acid receptor cell Bombyx mori Inhibition Iodobenzene Olfactory receptor benzoic acid halide halogen iodine iodobenzene linalool action potential antenna article controlled study inhibition kinetics nerve cell stimulation nerve conduction nonhuman olfactory receptor priority journal rebound receptor binding receptor potential sensory system electrophysiology silkworm stimulus response Bombyx Bombyx mori |
| description |
As shown in single-sensillum recordings, iodobenzene has a bimodal effect on the receptor cell tuned to benzoic acid (BA) of the female silk moth Bombyx mor. Exposure to iodobenzene causes an inhibition of the response to BA. With stimulation by iodobenzene alone, a reduction of basic nerve impulse firing during exposure is followed by a transient post-stimulus excitation (rebound). We suggest that inhibition suppresses excitation during exposure but fades afterwards more rapidly than excitation. Due to the spatial equivalence of the iodine and the acid residue, these effects might indicate opposing interactions of iodobenzene with the specific site for the key compound BA. This is supported by the fact that substitutions by smaller halogens are less effective in both inhibition and rebound. The inhibitory effect but not the rebound with iodobenzene alone was also observed in receptor cells tuned to key compounds other than benzoic acid, e.g. in the cell most sensitive to 2,6-dimethyl-5-heptene-2-ol (DMH-cell) occurring in the same sensillum as the BA-cell, or in the bombykol- and bombykal-cells of the male. At least in these cells the inhibitory effect might reflect the action of iodobenzene on a general site, e.g. the lipid matrix of the plasma membrane of the receptor cells. © The Author 2005. Published by Oxford University Press. All rights reserved. |
| format |
JOUR |
| author |
de Brito Sanchez, M.G. Kaissling, K.-E. |
| author_facet |
de Brito Sanchez, M.G. Kaissling, K.-E. |
| author_sort |
de Brito Sanchez, M.G. |
| title |
Inhibitory and excitatory effects of iodobenzene on the antennal benzoic acid receptor cells of the female silk moth Bombyx mori L |
| title_short |
Inhibitory and excitatory effects of iodobenzene on the antennal benzoic acid receptor cells of the female silk moth Bombyx mori L |
| title_full |
Inhibitory and excitatory effects of iodobenzene on the antennal benzoic acid receptor cells of the female silk moth Bombyx mori L |
| title_fullStr |
Inhibitory and excitatory effects of iodobenzene on the antennal benzoic acid receptor cells of the female silk moth Bombyx mori L |
| title_full_unstemmed |
Inhibitory and excitatory effects of iodobenzene on the antennal benzoic acid receptor cells of the female silk moth Bombyx mori L |
| title_sort |
inhibitory and excitatory effects of iodobenzene on the antennal benzoic acid receptor cells of the female silk moth bombyx mori l |
| url |
http://hdl.handle.net/20.500.12110/paper_0379864X_v30_n5_p435_deBritoSanchez |
| work_keys_str_mv |
AT debritosanchezmg inhibitoryandexcitatoryeffectsofiodobenzeneontheantennalbenzoicacidreceptorcellsofthefemalesilkmothbombyxmoril AT kaisslingke inhibitoryandexcitatoryeffectsofiodobenzeneontheantennalbenzoicacidreceptorcellsofthefemalesilkmothbombyxmoril |
| _version_ |
1807324012860145664 |