Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment

The Electrochemical treatment can be used for local control of solid tumors in both preclinical and clinical studies. In this paper, an integrated analysis of the spatial distributions of the electric potential, electric field, temperature and pH together with the acidic and basic areas are computed...

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Autores principales: Soba, A., Suárez, C., González, M.M., Cabrales, L.E.B., Pupo, A.E.B., Reyes, J.B., Martínez Tassé, J.P.
Formato: JOUR
Materias:
Electric field intensity
Electrode arrays
pH fronts
Tissue damage
Electric fields
Electric potential
Electrodes
Finite element method
Numerical methods
Tissue
Tumors
Electric field intensities
Electrochemical treatments
Integrated analysis
Numerical solution method
Temperature increment
Two-dimensional domain
Electrochemical electrodes
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03784754_v146_n_p160_Soba
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_03784754_v146_n_p160_Soba2023-10-03T15:33:05Z Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment Soba, A. Suárez, C. González, M.M. Cabrales, L.E.B. Pupo, A.E.B. Reyes, J.B. Martínez Tassé, J.P. Electric field intensity Electrode arrays pH fronts Tissue damage Electric fields Electric potential Electrodes Finite element method Numerical methods Tissue Tumors Electric field intensities Electrochemical treatments Electrode arrays Integrated analysis Numerical solution method Temperature increment Tissue damage Two-dimensional domain Electrochemical electrodes The Electrochemical treatment can be used for local control of solid tumors in both preclinical and clinical studies. In this paper, an integrated analysis of the spatial distributions of the electric potential, electric field, temperature and pH together with the acidic and basic areas are computed, via Finite Element Methods, to improve the geometrical description of electrode arrays for a better electrochemical treatment. These physical quantities are generated by different polarization modes and shapes of electrode arrays. Additionally, the equations over a rectangular two-dimensional domain, which represents the tumor tissue, are solved. The results demonstrate how the electric potential, electric field, temperature and pH distributions depend strongly on the electrode array. Furthermore, significant pH changes and temperature increments are shown after 60 min of treatment. The numerical results agree with the analytical ones reported in the literature. It is concluded that the numerical solution method permits to make an integral analysis, prediction and rapid visualization of the most important electrochemical variables that take place in tumor destruction, thus, providing the possibility of a more effective therapeutic planning before electrochemical treatment isconducted. © 2017 International Association for Mathematics and Computers in Simulation (IMACS) JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03784754_v146_n_p160_Soba
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Electric field intensity
Electrode arrays
pH fronts
Tissue damage
Electric fields
Electric potential
Electrodes
Finite element method
Numerical methods
Tissue
Tumors
Electric field intensities
Electrochemical treatments
Electrode arrays
Integrated analysis
Numerical solution method
Temperature increment
Tissue damage
Two-dimensional domain
Electrochemical electrodes
spellingShingle Electric field intensity
Electrode arrays
pH fronts
Tissue damage
Electric fields
Electric potential
Electrodes
Finite element method
Numerical methods
Tissue
Tumors
Electric field intensities
Electrochemical treatments
Electrode arrays
Integrated analysis
Numerical solution method
Temperature increment
Tissue damage
Two-dimensional domain
Electrochemical electrodes
Soba, A.
Suárez, C.
González, M.M.
Cabrales, L.E.B.
Pupo, A.E.B.
Reyes, J.B.
Martínez Tassé, J.P.
Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment
topic_facet Electric field intensity
Electrode arrays
pH fronts
Tissue damage
Electric fields
Electric potential
Electrodes
Finite element method
Numerical methods
Tissue
Tumors
Electric field intensities
Electrochemical treatments
Electrode arrays
Integrated analysis
Numerical solution method
Temperature increment
Tissue damage
Two-dimensional domain
Electrochemical electrodes
description The Electrochemical treatment can be used for local control of solid tumors in both preclinical and clinical studies. In this paper, an integrated analysis of the spatial distributions of the electric potential, electric field, temperature and pH together with the acidic and basic areas are computed, via Finite Element Methods, to improve the geometrical description of electrode arrays for a better electrochemical treatment. These physical quantities are generated by different polarization modes and shapes of electrode arrays. Additionally, the equations over a rectangular two-dimensional domain, which represents the tumor tissue, are solved. The results demonstrate how the electric potential, electric field, temperature and pH distributions depend strongly on the electrode array. Furthermore, significant pH changes and temperature increments are shown after 60 min of treatment. The numerical results agree with the analytical ones reported in the literature. It is concluded that the numerical solution method permits to make an integral analysis, prediction and rapid visualization of the most important electrochemical variables that take place in tumor destruction, thus, providing the possibility of a more effective therapeutic planning before electrochemical treatment isconducted. © 2017 International Association for Mathematics and Computers in Simulation (IMACS)
format JOUR
author Soba, A.
Suárez, C.
González, M.M.
Cabrales, L.E.B.
Pupo, A.E.B.
Reyes, J.B.
Martínez Tassé, J.P.
author_facet Soba, A.
Suárez, C.
González, M.M.
Cabrales, L.E.B.
Pupo, A.E.B.
Reyes, J.B.
Martínez Tassé, J.P.
author_sort Soba, A.
title Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment
title_short Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment
title_full Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment
title_fullStr Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment
title_full_unstemmed Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment
title_sort integrated analysis of the potential, electric field, temperature, ph and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment
url http://hdl.handle.net/20.500.12110/paper_03784754_v146_n_p160_Soba
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