Biosynthesis of fatty acids and triacylglycerols by 2,6,10,14-tetramethyl pentadecane-grown cells of Nocardia globerula 432
Nocardia globerula strain 432 was able to synthesize triacylglycerols (TAG) during cultivation on 2,6,10,14-tetramethyl pentadecane (pristane) under nitrogen-limiting conditions. Within these cells, 4,8,12-trimethyl tridecanoic acid was the major fatty acid detected. Fatty acids with an odd number o...
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todo:paper_03781097_v200_n2_p195_Alvarez2023-10-03T15:31:41Z Biosynthesis of fatty acids and triacylglycerols by 2,6,10,14-tetramethyl pentadecane-grown cells of Nocardia globerula 432 Alvarez, H.M. Souto, M.F. Viale, A. Pucci, O.H. Fatty acid Nocardia globerula Pristane Triacylglycerol 2,6,10,14 tetramethyl pentadecane 4,8,12 trimethyl tridecanoic acid acrylic acid alkane derivative decanoic acid derivative fatty acid derivative propionyl coenzyme A triacylglycerol unclassified drug Actinomyces article cell culture controlled study fatty acid oxidation fatty acid synthesis nocardia globerula nonhuman priority journal Acetates Acrylates Carcinogens Drug Interactions Fatty Acids Nocardia Terpenes Triglycerides Nocardia globerula strain 432 was able to synthesize triacylglycerols (TAG) during cultivation on 2,6,10,14-tetramethyl pentadecane (pristane) under nitrogen-limiting conditions. Within these cells, 4,8,12-trimethyl tridecanoic acid was the major fatty acid detected. Fatty acids with an odd number of carbon atoms and minor amounts of even-numbered fatty acids were also observed. Experiments carried out with acrylic acid, an inhibitor of β-oxidation, suggested that odd-numbered fatty acids such as C15:0, C17:0 and 10-methyl C17:0 were synthesized de novo using propionyl-CoA, the β-oxidation product, as precursor. Although N. globerula 432 incorporated mainly straight chain fatty acids into TAG, the branched fatty acid 4,8,12-trimethyl tridecanoic acid also appeared, to some extent, in the acylglycerols. The importance of TAG biosynthesis by pristane-grown cells of N. globerula strain 432 is discussed. © 2001 Federation of European Microbiological Societies. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03781097_v200_n2_p195_Alvarez |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Fatty acid Nocardia globerula Pristane Triacylglycerol 2,6,10,14 tetramethyl pentadecane 4,8,12 trimethyl tridecanoic acid acrylic acid alkane derivative decanoic acid derivative fatty acid derivative propionyl coenzyme A triacylglycerol unclassified drug Actinomyces article cell culture controlled study fatty acid oxidation fatty acid synthesis nocardia globerula nonhuman priority journal Acetates Acrylates Carcinogens Drug Interactions Fatty Acids Nocardia Terpenes Triglycerides |
| spellingShingle |
Fatty acid Nocardia globerula Pristane Triacylglycerol 2,6,10,14 tetramethyl pentadecane 4,8,12 trimethyl tridecanoic acid acrylic acid alkane derivative decanoic acid derivative fatty acid derivative propionyl coenzyme A triacylglycerol unclassified drug Actinomyces article cell culture controlled study fatty acid oxidation fatty acid synthesis nocardia globerula nonhuman priority journal Acetates Acrylates Carcinogens Drug Interactions Fatty Acids Nocardia Terpenes Triglycerides Alvarez, H.M. Souto, M.F. Viale, A. Pucci, O.H. Biosynthesis of fatty acids and triacylglycerols by 2,6,10,14-tetramethyl pentadecane-grown cells of Nocardia globerula 432 |
| topic_facet |
Fatty acid Nocardia globerula Pristane Triacylglycerol 2,6,10,14 tetramethyl pentadecane 4,8,12 trimethyl tridecanoic acid acrylic acid alkane derivative decanoic acid derivative fatty acid derivative propionyl coenzyme A triacylglycerol unclassified drug Actinomyces article cell culture controlled study fatty acid oxidation fatty acid synthesis nocardia globerula nonhuman priority journal Acetates Acrylates Carcinogens Drug Interactions Fatty Acids Nocardia Terpenes Triglycerides |
| description |
Nocardia globerula strain 432 was able to synthesize triacylglycerols (TAG) during cultivation on 2,6,10,14-tetramethyl pentadecane (pristane) under nitrogen-limiting conditions. Within these cells, 4,8,12-trimethyl tridecanoic acid was the major fatty acid detected. Fatty acids with an odd number of carbon atoms and minor amounts of even-numbered fatty acids were also observed. Experiments carried out with acrylic acid, an inhibitor of β-oxidation, suggested that odd-numbered fatty acids such as C15:0, C17:0 and 10-methyl C17:0 were synthesized de novo using propionyl-CoA, the β-oxidation product, as precursor. Although N. globerula 432 incorporated mainly straight chain fatty acids into TAG, the branched fatty acid 4,8,12-trimethyl tridecanoic acid also appeared, to some extent, in the acylglycerols. The importance of TAG biosynthesis by pristane-grown cells of N. globerula strain 432 is discussed. © 2001 Federation of European Microbiological Societies. |
| format |
JOUR |
| author |
Alvarez, H.M. Souto, M.F. Viale, A. Pucci, O.H. |
| author_facet |
Alvarez, H.M. Souto, M.F. Viale, A. Pucci, O.H. |
| author_sort |
Alvarez, H.M. |
| title |
Biosynthesis of fatty acids and triacylglycerols by 2,6,10,14-tetramethyl pentadecane-grown cells of Nocardia globerula 432 |
| title_short |
Biosynthesis of fatty acids and triacylglycerols by 2,6,10,14-tetramethyl pentadecane-grown cells of Nocardia globerula 432 |
| title_full |
Biosynthesis of fatty acids and triacylglycerols by 2,6,10,14-tetramethyl pentadecane-grown cells of Nocardia globerula 432 |
| title_fullStr |
Biosynthesis of fatty acids and triacylglycerols by 2,6,10,14-tetramethyl pentadecane-grown cells of Nocardia globerula 432 |
| title_full_unstemmed |
Biosynthesis of fatty acids and triacylglycerols by 2,6,10,14-tetramethyl pentadecane-grown cells of Nocardia globerula 432 |
| title_sort |
biosynthesis of fatty acids and triacylglycerols by 2,6,10,14-tetramethyl pentadecane-grown cells of nocardia globerula 432 |
| url |
http://hdl.handle.net/20.500.12110/paper_03781097_v200_n2_p195_Alvarez |
| work_keys_str_mv |
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1782029127009697792 |