A simple preparation ofan 18-oxygenated pregnane
Reductive oxygenation of (20R)-3β,20-diacetoxy-18-iodo-5-pregnene allowed the substitution of the neopentylic iodine at position 18 by a hydroxyl group, in high yield. Partial acetate migration from C-20 to C-18 was observed. Evidence is presented, which indicates that this migration occurs after fo...
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| Autores principales: | , , |
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| Formato: | JOUR |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_03650375_v86_n3-6_p336_Nicoletti |
| Aporte de: |
| Sumario: | Reductive oxygenation of (20R)-3β,20-diacetoxy-18-iodo-5-pregnene allowed the substitution of the neopentylic iodine at position 18 by a hydroxyl group, in high yield. Partial acetate migration from C-20 to C-18 was observed. Evidence is presented, which indicates that this migration occurs after formation of the 18-alcohol. |
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