A chemical approach to the understanding of schizophrenia

In this paper we show that the experimental psychosis observed after drinking Hoasca reproduces the pathologic transmethylation theory of schizophrenia. The occurrence of N,N-dimethyltryptamine (DMT) in the Hoasca drink and in the urine samples of subjects supports now that the chemical and neuropsy...

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Autores principales: Pomilio, A.B., Vitale, A.A., Ciprian-Ollivier, J., Cetkovich-Bakmas, M.
Formato: JOUR
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03650375_v86_n3-6_p320_Pomilio
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_03650375_v86_n3-6_p320_Pomilio
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spelling todo:paper_03650375_v86_n3-6_p320_Pomilio2023-10-03T15:27:55Z A chemical approach to the understanding of schizophrenia Pomilio, A.B. Vitale, A.A. Ciprian-Ollivier, J. Cetkovich-Bakmas, M. In this paper we show that the experimental psychosis observed after drinking Hoasca reproduces the pathologic transmethylation theory of schizophrenia. The occurrence of N,N-dimethyltryptamine (DMT) in the Hoasca drink and in the urine samples of subjects supports now that the chemical and neuropsychological effects are produced by this methylated indolealkylamine assisted by the β-carboline derivatives. These results further confirm that the urinary hallucinogenic compounds detected in healthy subjects (post-Hoasca, but not before) are the same as those found in the urine samples of acute psychotic unmedicated patients. The ability of Hoasca to modulate serotonergic receptors was evaluated, and thereby to which extent cortisol, prolactin and serotonin levels as well as perceptual and cognitive processes were affected. The degree of Hoasca monoamine oxidase (MAO) inhibition was directly correlated with the concentration of MAO-inhibiting β-carbolines. The additive combination of harmine and tetrahydroharmine (THH) accounts for the MAO inhibition exhibited by Hoasca. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03650375_v86_n3-6_p320_Pomilio
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
description In this paper we show that the experimental psychosis observed after drinking Hoasca reproduces the pathologic transmethylation theory of schizophrenia. The occurrence of N,N-dimethyltryptamine (DMT) in the Hoasca drink and in the urine samples of subjects supports now that the chemical and neuropsychological effects are produced by this methylated indolealkylamine assisted by the β-carboline derivatives. These results further confirm that the urinary hallucinogenic compounds detected in healthy subjects (post-Hoasca, but not before) are the same as those found in the urine samples of acute psychotic unmedicated patients. The ability of Hoasca to modulate serotonergic receptors was evaluated, and thereby to which extent cortisol, prolactin and serotonin levels as well as perceptual and cognitive processes were affected. The degree of Hoasca monoamine oxidase (MAO) inhibition was directly correlated with the concentration of MAO-inhibiting β-carbolines. The additive combination of harmine and tetrahydroharmine (THH) accounts for the MAO inhibition exhibited by Hoasca.
format JOUR
author Pomilio, A.B.
Vitale, A.A.
Ciprian-Ollivier, J.
Cetkovich-Bakmas, M.
spellingShingle Pomilio, A.B.
Vitale, A.A.
Ciprian-Ollivier, J.
Cetkovich-Bakmas, M.
A chemical approach to the understanding of schizophrenia
author_facet Pomilio, A.B.
Vitale, A.A.
Ciprian-Ollivier, J.
Cetkovich-Bakmas, M.
author_sort Pomilio, A.B.
title A chemical approach to the understanding of schizophrenia
title_short A chemical approach to the understanding of schizophrenia
title_full A chemical approach to the understanding of schizophrenia
title_fullStr A chemical approach to the understanding of schizophrenia
title_full_unstemmed A chemical approach to the understanding of schizophrenia
title_sort chemical approach to the understanding of schizophrenia
url http://hdl.handle.net/20.500.12110/paper_03650375_v86_n3-6_p320_Pomilio
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AT cetkovichbakmasm achemicalapproachtotheunderstandingofschizophrenia
AT pomilioab chemicalapproachtotheunderstandingofschizophrenia
AT vitaleaa chemicalapproachtotheunderstandingofschizophrenia
AT ciprianollivierj chemicalapproachtotheunderstandingofschizophrenia
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