Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle

The neuregulin receptor tyrosine kinase Erb-b4, initially linked to early cardiac development, is shown here to play a critical role in adult cardiac function. In wild-type mice, Erb-b4 protein localized to Z lines and to intercalated disks, suggesting a role in subcellular and intercellular communi...

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Autores principales:	García-Rivello, H., Taranda, J., Said, M., Cabeza-Meckert, P., Vila-Petroff, M., Scaglione, J., Ghio, S., Chen, J., Lai, C., Laguens, R.P., Lloyd, K.C., Hertig, C.M.
Formato:	JOUR
Materias:	Conditional knockout erb-b2 Heart Mouse Neuregulin actin atrial natriuretic factor brain natriuretic peptide cre recombinase epidermal growth factor receptor 4 indo 1 myosin light chain animal experiment animal model animal tissue article cell communication cellular distribution congestive cardiomyopathy controlled study electrocardiography female gene inactivation gene targeting heart development heart muscle cell heart muscle contractility heart ventricle hypertrophy heterozygosity histochemistry immunofluorescence knockout mouse mouse nick end labeling nonhuman priority journal reverse transcription polymerase chain reaction Western blotting wild type Animals Cardiomegaly Cardiomyopathy, Dilated Disease Models, Animal Female Male Mice Mice, Inbred C57BL Mice, Knockout Myocardial Contraction Myocardium Receptor, Epidermal Growth Factor Signal Transduction
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03636135_v289_n358-3_pH1153_GarciaRivello
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_03636135_v289_n358-3_pH1153_GarciaRivello
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spelling	todo:paper_03636135_v289_n358-3_pH1153_GarciaRivello2023-10-03T15:27:30Z Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle García-Rivello, H. Taranda, J. Said, M. Cabeza-Meckert, P. Vila-Petroff, M. Scaglione, J. Ghio, S. Chen, J. Lai, C. Laguens, R.P. Lloyd, K.C. Hertig, C.M. Conditional knockout erb-b2 Heart Mouse Neuregulin actin atrial natriuretic factor brain natriuretic peptide cre recombinase epidermal growth factor receptor 4 indo 1 myosin light chain animal experiment animal model animal tissue article cell communication cellular distribution congestive cardiomyopathy controlled study electrocardiography female gene inactivation gene targeting heart development heart muscle cell heart muscle contractility heart ventricle hypertrophy heterozygosity histochemistry immunofluorescence knockout mouse mouse nick end labeling nonhuman priority journal reverse transcription polymerase chain reaction Western blotting wild type Animals Cardiomegaly Cardiomyopathy, Dilated Disease Models, Animal Female Male Mice Mice, Inbred C57BL Mice, Knockout Myocardial Contraction Myocardium Receptor, Epidermal Growth Factor Signal Transduction The neuregulin receptor tyrosine kinase Erb-b4, initially linked to early cardiac development, is shown here to play a critical role in adult cardiac function. In wild-type mice, Erb-b4 protein localized to Z lines and to intercalated disks, suggesting a role in subcellular and intercellular communications of cardiomyocytes. Conditional inactivation of erb-b4 in ventricular muscle cells led to a severe dilated cardiomyopathy, characterized by thinned ventricular walls with eccentric hypertrophy, reduced contractility, and delayed conduction. This cardiac dysfunction may account for premature death in adult erb-b4-knockout mice. This study establishes a critical role for Erb-b4 in the maintenance of normal postnatal cardiac structure and function. Copyright © 2005 the American Physiological Society. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03636135_v289_n358-3_pH1153_GarciaRivello
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Conditional knockout erb-b2 Heart Mouse Neuregulin actin atrial natriuretic factor brain natriuretic peptide cre recombinase epidermal growth factor receptor 4 indo 1 myosin light chain animal experiment animal model animal tissue article cell communication cellular distribution congestive cardiomyopathy controlled study electrocardiography female gene inactivation gene targeting heart development heart muscle cell heart muscle contractility heart ventricle hypertrophy heterozygosity histochemistry immunofluorescence knockout mouse mouse nick end labeling nonhuman priority journal reverse transcription polymerase chain reaction Western blotting wild type Animals Cardiomegaly Cardiomyopathy, Dilated Disease Models, Animal Female Male Mice Mice, Inbred C57BL Mice, Knockout Myocardial Contraction Myocardium Receptor, Epidermal Growth Factor Signal Transduction
spellingShingle	Conditional knockout erb-b2 Heart Mouse Neuregulin actin atrial natriuretic factor brain natriuretic peptide cre recombinase epidermal growth factor receptor 4 indo 1 myosin light chain animal experiment animal model animal tissue article cell communication cellular distribution congestive cardiomyopathy controlled study electrocardiography female gene inactivation gene targeting heart development heart muscle cell heart muscle contractility heart ventricle hypertrophy heterozygosity histochemistry immunofluorescence knockout mouse mouse nick end labeling nonhuman priority journal reverse transcription polymerase chain reaction Western blotting wild type Animals Cardiomegaly Cardiomyopathy, Dilated Disease Models, Animal Female Male Mice Mice, Inbred C57BL Mice, Knockout Myocardial Contraction Myocardium Receptor, Epidermal Growth Factor Signal Transduction García-Rivello, H. Taranda, J. Said, M. Cabeza-Meckert, P. Vila-Petroff, M. Scaglione, J. Ghio, S. Chen, J. Lai, C. Laguens, R.P. Lloyd, K.C. Hertig, C.M. Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle
topic_facet	Conditional knockout erb-b2 Heart Mouse Neuregulin actin atrial natriuretic factor brain natriuretic peptide cre recombinase epidermal growth factor receptor 4 indo 1 myosin light chain animal experiment animal model animal tissue article cell communication cellular distribution congestive cardiomyopathy controlled study electrocardiography female gene inactivation gene targeting heart development heart muscle cell heart muscle contractility heart ventricle hypertrophy heterozygosity histochemistry immunofluorescence knockout mouse mouse nick end labeling nonhuman priority journal reverse transcription polymerase chain reaction Western blotting wild type Animals Cardiomegaly Cardiomyopathy, Dilated Disease Models, Animal Female Male Mice Mice, Inbred C57BL Mice, Knockout Myocardial Contraction Myocardium Receptor, Epidermal Growth Factor Signal Transduction
description	The neuregulin receptor tyrosine kinase Erb-b4, initially linked to early cardiac development, is shown here to play a critical role in adult cardiac function. In wild-type mice, Erb-b4 protein localized to Z lines and to intercalated disks, suggesting a role in subcellular and intercellular communications of cardiomyocytes. Conditional inactivation of erb-b4 in ventricular muscle cells led to a severe dilated cardiomyopathy, characterized by thinned ventricular walls with eccentric hypertrophy, reduced contractility, and delayed conduction. This cardiac dysfunction may account for premature death in adult erb-b4-knockout mice. This study establishes a critical role for Erb-b4 in the maintenance of normal postnatal cardiac structure and function. Copyright © 2005 the American Physiological Society.
format	JOUR
author	García-Rivello, H. Taranda, J. Said, M. Cabeza-Meckert, P. Vila-Petroff, M. Scaglione, J. Ghio, S. Chen, J. Lai, C. Laguens, R.P. Lloyd, K.C. Hertig, C.M.
author_facet	García-Rivello, H. Taranda, J. Said, M. Cabeza-Meckert, P. Vila-Petroff, M. Scaglione, J. Ghio, S. Chen, J. Lai, C. Laguens, R.P. Lloyd, K.C. Hertig, C.M.
author_sort	García-Rivello, H.
title	Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle
title_short	Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle
title_full	Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle
title_fullStr	Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle
title_full_unstemmed	Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle
title_sort	dilated cardiomyopathy in erb-b4-deficient ventricular muscle
url	http://hdl.handle.net/20.500.12110/paper_03636135_v289_n358-3_pH1153_GarciaRivello
work_keys_str_mv	AT garciarivelloh dilatedcardiomyopathyinerbb4deficientventricularmuscle AT tarandaj dilatedcardiomyopathyinerbb4deficientventricularmuscle AT saidm dilatedcardiomyopathyinerbb4deficientventricularmuscle AT cabezameckertp dilatedcardiomyopathyinerbb4deficientventricularmuscle AT vilapetroffm dilatedcardiomyopathyinerbb4deficientventricularmuscle AT scaglionej dilatedcardiomyopathyinerbb4deficientventricularmuscle AT ghios dilatedcardiomyopathyinerbb4deficientventricularmuscle AT chenj dilatedcardiomyopathyinerbb4deficientventricularmuscle AT laic dilatedcardiomyopathyinerbb4deficientventricularmuscle AT laguensrp dilatedcardiomyopathyinerbb4deficientventricularmuscle AT lloydkc dilatedcardiomyopathyinerbb4deficientventricularmuscle AT hertigcm dilatedcardiomyopathyinerbb4deficientventricularmuscle
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Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle

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