Preparation and biological evaluation of technetium‐99m‐phenylethylamine complexes

Biological and chemical characteristics of 99mTc‐phenethylamines complexes are presented. 2‐(4,5‐Dimethoxy‐2‐nitrophenyl)ethylamine, 2‐(3,4‐dimethoxyphenyl)ethylamine and 2‐(2‐amino‐4,5‐dimethoxyphenyl)‐ethylamine were used as ligands. A preliminary evaluation of these 99mTc‐complexes as dopamine re...

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Autores principales: Vitale, A.A., Calvino, M.A., Ferrari, C.C., Stahl, A.E., Pomilio, A.B.
Formato: JOUR
Materias:
rat
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03624803_v36_n6_p509_Vitale
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spelling todo:paper_03624803_v36_n6_p509_Vitale2023-10-03T15:27:07Z Preparation and biological evaluation of technetium‐99m‐phenylethylamine complexes Vitale, A.A. Calvino, M.A. Ferrari, C.C. Stahl, A.E. Pomilio, A.B. 2‐(2‐Amino‐4,5‐dimethoxyphenyl)ethylamine 2‐(3,4‐Dimethoxyphenyl)‐ethylamine 2‐(4,5‐Dimethoxy‐2‐nitrophenyl)ethylamine 99m‐Technetium complexes Biodistribution Preparation semiempirical ZINDO/1 calculations phenethylamine derivative technetium 99m technetium complex animal experiment article brain controlled study drug distribution drug structure drug synthesis electrophoresis female intracerebral drug administration isotope labeling nonhuman radiochromatography rat Animalia Biological and chemical characteristics of 99mTc‐phenethylamines complexes are presented. 2‐(4,5‐Dimethoxy‐2‐nitrophenyl)ethylamine, 2‐(3,4‐dimethoxyphenyl)ethylamine and 2‐(2‐amino‐4,5‐dimethoxyphenyl)‐ethylamine were used as ligands. A preliminary evaluation of these 99mTc‐complexes as dopamine receptor radioligands was also performed. Net charges at each atom were also calculated by a semiempirical ZINDO/1 method for comparison of free ligands' parameters with those of the respective technetium‐complexes. Copyright © 1995 John Wiley & Sons, Ltd. Fil:Vitale, A.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Calvino, M.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ferrari, C.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pomilio, A.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03624803_v36_n6_p509_Vitale
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic 2‐(2‐Amino‐4,5‐dimethoxyphenyl)ethylamine
2‐(3,4‐Dimethoxyphenyl)‐ethylamine
2‐(4,5‐Dimethoxy‐2‐nitrophenyl)ethylamine
99m‐Technetium complexes
Biodistribution
Preparation
semiempirical ZINDO/1 calculations
phenethylamine derivative
technetium 99m
technetium complex
animal experiment
article
brain
controlled study
drug distribution
drug structure
drug synthesis
electrophoresis
female
intracerebral drug administration
isotope labeling
nonhuman
radiochromatography
rat
Animalia
spellingShingle 2‐(2‐Amino‐4,5‐dimethoxyphenyl)ethylamine
2‐(3,4‐Dimethoxyphenyl)‐ethylamine
2‐(4,5‐Dimethoxy‐2‐nitrophenyl)ethylamine
99m‐Technetium complexes
Biodistribution
Preparation
semiempirical ZINDO/1 calculations
phenethylamine derivative
technetium 99m
technetium complex
animal experiment
article
brain
controlled study
drug distribution
drug structure
drug synthesis
electrophoresis
female
intracerebral drug administration
isotope labeling
nonhuman
radiochromatography
rat
Animalia
Vitale, A.A.
Calvino, M.A.
Ferrari, C.C.
Stahl, A.E.
Pomilio, A.B.
Preparation and biological evaluation of technetium‐99m‐phenylethylamine complexes
topic_facet 2‐(2‐Amino‐4,5‐dimethoxyphenyl)ethylamine
2‐(3,4‐Dimethoxyphenyl)‐ethylamine
2‐(4,5‐Dimethoxy‐2‐nitrophenyl)ethylamine
99m‐Technetium complexes
Biodistribution
Preparation
semiempirical ZINDO/1 calculations
phenethylamine derivative
technetium 99m
technetium complex
animal experiment
article
brain
controlled study
drug distribution
drug structure
drug synthesis
electrophoresis
female
intracerebral drug administration
isotope labeling
nonhuman
radiochromatography
rat
Animalia
description Biological and chemical characteristics of 99mTc‐phenethylamines complexes are presented. 2‐(4,5‐Dimethoxy‐2‐nitrophenyl)ethylamine, 2‐(3,4‐dimethoxyphenyl)ethylamine and 2‐(2‐amino‐4,5‐dimethoxyphenyl)‐ethylamine were used as ligands. A preliminary evaluation of these 99mTc‐complexes as dopamine receptor radioligands was also performed. Net charges at each atom were also calculated by a semiempirical ZINDO/1 method for comparison of free ligands' parameters with those of the respective technetium‐complexes. Copyright © 1995 John Wiley & Sons, Ltd.
format JOUR
author Vitale, A.A.
Calvino, M.A.
Ferrari, C.C.
Stahl, A.E.
Pomilio, A.B.
author_facet Vitale, A.A.
Calvino, M.A.
Ferrari, C.C.
Stahl, A.E.
Pomilio, A.B.
author_sort Vitale, A.A.
title Preparation and biological evaluation of technetium‐99m‐phenylethylamine complexes
title_short Preparation and biological evaluation of technetium‐99m‐phenylethylamine complexes
title_full Preparation and biological evaluation of technetium‐99m‐phenylethylamine complexes
title_fullStr Preparation and biological evaluation of technetium‐99m‐phenylethylamine complexes
title_full_unstemmed Preparation and biological evaluation of technetium‐99m‐phenylethylamine complexes
title_sort preparation and biological evaluation of technetium‐99m‐phenylethylamine complexes
url http://hdl.handle.net/20.500.12110/paper_03624803_v36_n6_p509_Vitale
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