Synthesis of [20,21‐13C2]‐pregnenolone

The synthesis of [20,21‐13C2]‐pregnenolone (7) from androst‐5‐en‐3β‐ol‐17‐one (1) is described. Labelled carbons were introduced by two procedures, namely, condensation of 1 with K13CN and Grignard reaction of nitrile derivative 5 with [13C]‐methylmagnesium iodide. Location of labels was confirmed b...

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Detalles Bibliográficos
Autores principales: Caballero, G.M., Gros, E.G.
Formato: JOUR
Materias:
synthesis
[20,21‐13C2]‐pregnenolone
carbon 13
pregnenolone
article
controlled study
drug synthesis
isotope labeling
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03624803_v33_n10_p907_Caballero
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_03624803_v33_n10_p907_Caballero
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spelling todo:paper_03624803_v33_n10_p907_Caballero2023-10-03T15:27:06Z Synthesis of [20,21‐13C2]‐pregnenolone Caballero, G.M. Gros, E.G. synthesis [20,21‐13C2]‐pregnenolone carbon 13 pregnenolone article controlled study drug synthesis isotope labeling The synthesis of [20,21‐13C2]‐pregnenolone (7) from androst‐5‐en‐3β‐ol‐17‐one (1) is described. Labelled carbons were introduced by two procedures, namely, condensation of 1 with K13CN and Grignard reaction of nitrile derivative 5 with [13C]‐methylmagnesium iodide. Location of labels was confirmed by 13C‐NMR spectroscopy. Copyright © 1993 John Wiley & Sons, Ltd. Fil:Caballero, G.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gros, E.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03624803_v33_n10_p907_Caballero
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic synthesis
[20,21‐13C2]‐pregnenolone
carbon 13
pregnenolone
article
controlled study
drug synthesis
isotope labeling
spellingShingle synthesis
[20,21‐13C2]‐pregnenolone
carbon 13
pregnenolone
article
controlled study
drug synthesis
isotope labeling
Caballero, G.M.
Gros, E.G.
Synthesis of [20,21‐13C2]‐pregnenolone
topic_facet synthesis
[20,21‐13C2]‐pregnenolone
carbon 13
pregnenolone
article
controlled study
drug synthesis
isotope labeling
description The synthesis of [20,21‐13C2]‐pregnenolone (7) from androst‐5‐en‐3β‐ol‐17‐one (1) is described. Labelled carbons were introduced by two procedures, namely, condensation of 1 with K13CN and Grignard reaction of nitrile derivative 5 with [13C]‐methylmagnesium iodide. Location of labels was confirmed by 13C‐NMR spectroscopy. Copyright © 1993 John Wiley & Sons, Ltd.
format JOUR
author Caballero, G.M.
Gros, E.G.
author_facet Caballero, G.M.
Gros, E.G.
author_sort Caballero, G.M.
title Synthesis of [20,21‐13C2]‐pregnenolone
title_short Synthesis of [20,21‐13C2]‐pregnenolone
title_full Synthesis of [20,21‐13C2]‐pregnenolone
title_fullStr Synthesis of [20,21‐13C2]‐pregnenolone
title_full_unstemmed Synthesis of [20,21‐13C2]‐pregnenolone
title_sort synthesis of [20,21‐13c2]‐pregnenolone
url http://hdl.handle.net/20.500.12110/paper_03624803_v33_n10_p907_Caballero
work_keys_str_mv AT caballerogm synthesisof202113c2pregnenolone
AT groseg synthesisof202113c2pregnenolone
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