Synthesis of |24‐14C|‐23‐norcholanoic acid derivatives
Syntheses of |24‐14C| 3β, 20ξ‐dihydroxy‐23‐norchol‐5‐enoic acid, |24‐14C| 3β, 20ξ‐dihydroxy‐23‐norcholanoic acid and |24‐14C| 20ξ‐hydroxy‐3‐oxo‐23‐norchol‐4‐enoic acid were accomplished by reaction of ethyl |1‐14C| bromoacetate, in Reformatsky conditions, with suitable 20‐keto‐pregnane derivatives....
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todo:paper_03624803_v22_n5_p467_Maier2023-10-03T15:27:04Z Synthesis of |24‐14C|‐23‐norcholanoic acid derivatives Maier, M.S. Seldes, A.M. Gros, E.G. Ethyl |1‐14C| bromoacetate Reformatsky reaction Synthesis |24‐14C|‐23‐Norcholanic acid derivatives radioisotope 20 hydroxy 3 oxo 23 norchol 4 enoic acid c 14 3 oxo 23 norchola 4,20(22) dienoic acid c 14 3beta hydroxy 23 norchol 20(22) enoic acid c 14 3beta hydroxy 23 norchola 5,20(22) dienoic acid c 14 3beta,20 dihydroxy 23 norchol 5 enoic acid c 14 3beta,20 dihydroxy 23 norcholanic acid c 14 drug analysis drug identification drug synthesis infrared spectrometry mass spectrometry nonhuman nuclear magnetic resonance priority journal theoretical study Syntheses of |24‐14C| 3β, 20ξ‐dihydroxy‐23‐norchol‐5‐enoic acid, |24‐14C| 3β, 20ξ‐dihydroxy‐23‐norcholanoic acid and |24‐14C| 20ξ‐hydroxy‐3‐oxo‐23‐norchol‐4‐enoic acid were accomplished by reaction of ethyl |1‐14C| bromoacetate, in Reformatsky conditions, with suitable 20‐keto‐pregnane derivatives. Dehydration of these products afforded |24‐14C| 3β‐hydroxy‐23‐norchola‐5, 20(22)E‐enoic acid and |24‐14C| 3‐oxo‐23‐norchola‐4, 20(22)E‐dienoic acid respectively. The products were characterized by spectroscopic (IR, 1H NMR, MS) methods. Copyright © 1985 John Wiley & Sons, Ltd. Fil:Maier, M.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Seldes, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gros, E.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03624803_v22_n5_p467_Maier |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
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Ethyl |1‐14C| bromoacetate Reformatsky reaction Synthesis |24‐14C|‐23‐Norcholanic acid derivatives radioisotope 20 hydroxy 3 oxo 23 norchol 4 enoic acid c 14 3 oxo 23 norchola 4,20(22) dienoic acid c 14 3beta hydroxy 23 norchol 20(22) enoic acid c 14 3beta hydroxy 23 norchola 5,20(22) dienoic acid c 14 3beta,20 dihydroxy 23 norchol 5 enoic acid c 14 3beta,20 dihydroxy 23 norcholanic acid c 14 drug analysis drug identification drug synthesis infrared spectrometry mass spectrometry nonhuman nuclear magnetic resonance priority journal theoretical study |
| spellingShingle |
Ethyl |1‐14C| bromoacetate Reformatsky reaction Synthesis |24‐14C|‐23‐Norcholanic acid derivatives radioisotope 20 hydroxy 3 oxo 23 norchol 4 enoic acid c 14 3 oxo 23 norchola 4,20(22) dienoic acid c 14 3beta hydroxy 23 norchol 20(22) enoic acid c 14 3beta hydroxy 23 norchola 5,20(22) dienoic acid c 14 3beta,20 dihydroxy 23 norchol 5 enoic acid c 14 3beta,20 dihydroxy 23 norcholanic acid c 14 drug analysis drug identification drug synthesis infrared spectrometry mass spectrometry nonhuman nuclear magnetic resonance priority journal theoretical study Maier, M.S. Seldes, A.M. Gros, E.G. Synthesis of |24‐14C|‐23‐norcholanoic acid derivatives |
| topic_facet |
Ethyl |1‐14C| bromoacetate Reformatsky reaction Synthesis |24‐14C|‐23‐Norcholanic acid derivatives radioisotope 20 hydroxy 3 oxo 23 norchol 4 enoic acid c 14 3 oxo 23 norchola 4,20(22) dienoic acid c 14 3beta hydroxy 23 norchol 20(22) enoic acid c 14 3beta hydroxy 23 norchola 5,20(22) dienoic acid c 14 3beta,20 dihydroxy 23 norchol 5 enoic acid c 14 3beta,20 dihydroxy 23 norcholanic acid c 14 drug analysis drug identification drug synthesis infrared spectrometry mass spectrometry nonhuman nuclear magnetic resonance priority journal theoretical study |
| description |
Syntheses of |24‐14C| 3β, 20ξ‐dihydroxy‐23‐norchol‐5‐enoic acid, |24‐14C| 3β, 20ξ‐dihydroxy‐23‐norcholanoic acid and |24‐14C| 20ξ‐hydroxy‐3‐oxo‐23‐norchol‐4‐enoic acid were accomplished by reaction of ethyl |1‐14C| bromoacetate, in Reformatsky conditions, with suitable 20‐keto‐pregnane derivatives. Dehydration of these products afforded |24‐14C| 3β‐hydroxy‐23‐norchola‐5, 20(22)E‐enoic acid and |24‐14C| 3‐oxo‐23‐norchola‐4, 20(22)E‐dienoic acid respectively. The products were characterized by spectroscopic (IR, 1H NMR, MS) methods. Copyright © 1985 John Wiley & Sons, Ltd. |
| format |
JOUR |
| author |
Maier, M.S. Seldes, A.M. Gros, E.G. |
| author_facet |
Maier, M.S. Seldes, A.M. Gros, E.G. |
| author_sort |
Maier, M.S. |
| title |
Synthesis of |24‐14C|‐23‐norcholanoic acid derivatives |
| title_short |
Synthesis of |24‐14C|‐23‐norcholanoic acid derivatives |
| title_full |
Synthesis of |24‐14C|‐23‐norcholanoic acid derivatives |
| title_fullStr |
Synthesis of |24‐14C|‐23‐norcholanoic acid derivatives |
| title_full_unstemmed |
Synthesis of |24‐14C|‐23‐norcholanoic acid derivatives |
| title_sort |
synthesis of |24‐14c|‐23‐norcholanoic acid derivatives |
| url |
http://hdl.handle.net/20.500.12110/paper_03624803_v22_n5_p467_Maier |
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AT maierms synthesisof2414c23norcholanoicacidderivatives AT seldesam synthesisof2414c23norcholanoicacidderivatives AT groseg synthesisof2414c23norcholanoicacidderivatives |
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1782025405526441984 |