The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide
Although lymphomas account for almost half of blood-derived cancers that are diagnosed each year, the causes of new cases are poorly understood, as reflected by the relatively few risk factors established. Galectin-1, an immunoregulatory β-galactoside-binding protein, has been widely associated with...
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todo:paper_03407004_v61_n4_p469_ZacariasFluck2023-10-03T15:25:49Z The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide Zacarías Fluck, M.F. Hess, L. Salatino, M. Croci, D.O. Stupirski, J.C. Di Masso, R.J. Roggero, E. Rabinovich, G.A. Scharovsky, O.G. Aggressiveness Cyclophosphamide Galectin-1 Lymphoma cyclophosphamide galectin 1 animal experiment animal model animal tissue article cancer chemotherapy cancer growth cancer regression controlled study correlation analysis disease activity female growth rate in vivo study metastasis potential mouse nonhuman outcome assessment priority journal protein expression single drug dose T cell lymphoma treatment response Animals Antigens, CD4 Cell Proliferation Cyclophosphamide Female Forkhead Transcription Factors Galectin 1 Gene Expression Regulation, Neoplastic Humans Immunosuppression Interleukin-2 Receptor alpha Subunit Lymphoma, T-Cell Mice Neoplasm Metastasis T-Lymphocytes, Regulatory Although lymphomas account for almost half of blood-derived cancers that are diagnosed each year, the causes of new cases are poorly understood, as reflected by the relatively few risk factors established. Galectin-1, an immunoregulatory β-galactoside-binding protein, has been widely associated with tumor-immune escape. The aim of the present work was to study the relationship between tumor growth rate, aggressiveness, and response to cyclophosphamide (Cy) therapy with regard to Gal-1 expression in murine T-cell lymphoma models. By means of a disruptive selection process for tumor growth rate, we generated two lymphoma variants from a parental T-cell lymphoma, which have unique characteristics in terms of tumor growth rate, spontaneous regression, metastatic capacity, Gal-1 expression and sensitivity to Cy therapy. Here, we show that Gal-1 expression strongly correlates with tumor growth rate, metastatic capacity and response to singledose Cy therapy in T-cell lymphoma models; this association might have important consequences for evaluating prognosis and treatments of this type of tumors. © Springer-Verlag 2011. Fil:Salatino, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Croci, D.O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03407004_v61_n4_p469_ZacariasFluck |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Aggressiveness Cyclophosphamide Galectin-1 Lymphoma cyclophosphamide galectin 1 animal experiment animal model animal tissue article cancer chemotherapy cancer growth cancer regression controlled study correlation analysis disease activity female growth rate in vivo study metastasis potential mouse nonhuman outcome assessment priority journal protein expression single drug dose T cell lymphoma treatment response Animals Antigens, CD4 Cell Proliferation Cyclophosphamide Female Forkhead Transcription Factors Galectin 1 Gene Expression Regulation, Neoplastic Humans Immunosuppression Interleukin-2 Receptor alpha Subunit Lymphoma, T-Cell Mice Neoplasm Metastasis T-Lymphocytes, Regulatory |
spellingShingle |
Aggressiveness Cyclophosphamide Galectin-1 Lymphoma cyclophosphamide galectin 1 animal experiment animal model animal tissue article cancer chemotherapy cancer growth cancer regression controlled study correlation analysis disease activity female growth rate in vivo study metastasis potential mouse nonhuman outcome assessment priority journal protein expression single drug dose T cell lymphoma treatment response Animals Antigens, CD4 Cell Proliferation Cyclophosphamide Female Forkhead Transcription Factors Galectin 1 Gene Expression Regulation, Neoplastic Humans Immunosuppression Interleukin-2 Receptor alpha Subunit Lymphoma, T-Cell Mice Neoplasm Metastasis T-Lymphocytes, Regulatory Zacarías Fluck, M.F. Hess, L. Salatino, M. Croci, D.O. Stupirski, J.C. Di Masso, R.J. Roggero, E. Rabinovich, G.A. Scharovsky, O.G. The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide |
topic_facet |
Aggressiveness Cyclophosphamide Galectin-1 Lymphoma cyclophosphamide galectin 1 animal experiment animal model animal tissue article cancer chemotherapy cancer growth cancer regression controlled study correlation analysis disease activity female growth rate in vivo study metastasis potential mouse nonhuman outcome assessment priority journal protein expression single drug dose T cell lymphoma treatment response Animals Antigens, CD4 Cell Proliferation Cyclophosphamide Female Forkhead Transcription Factors Galectin 1 Gene Expression Regulation, Neoplastic Humans Immunosuppression Interleukin-2 Receptor alpha Subunit Lymphoma, T-Cell Mice Neoplasm Metastasis T-Lymphocytes, Regulatory |
description |
Although lymphomas account for almost half of blood-derived cancers that are diagnosed each year, the causes of new cases are poorly understood, as reflected by the relatively few risk factors established. Galectin-1, an immunoregulatory β-galactoside-binding protein, has been widely associated with tumor-immune escape. The aim of the present work was to study the relationship between tumor growth rate, aggressiveness, and response to cyclophosphamide (Cy) therapy with regard to Gal-1 expression in murine T-cell lymphoma models. By means of a disruptive selection process for tumor growth rate, we generated two lymphoma variants from a parental T-cell lymphoma, which have unique characteristics in terms of tumor growth rate, spontaneous regression, metastatic capacity, Gal-1 expression and sensitivity to Cy therapy. Here, we show that Gal-1 expression strongly correlates with tumor growth rate, metastatic capacity and response to singledose Cy therapy in T-cell lymphoma models; this association might have important consequences for evaluating prognosis and treatments of this type of tumors. © Springer-Verlag 2011. |
format |
JOUR |
author |
Zacarías Fluck, M.F. Hess, L. Salatino, M. Croci, D.O. Stupirski, J.C. Di Masso, R.J. Roggero, E. Rabinovich, G.A. Scharovsky, O.G. |
author_facet |
Zacarías Fluck, M.F. Hess, L. Salatino, M. Croci, D.O. Stupirski, J.C. Di Masso, R.J. Roggero, E. Rabinovich, G.A. Scharovsky, O.G. |
author_sort |
Zacarías Fluck, M.F. |
title |
The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide |
title_short |
The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide |
title_full |
The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide |
title_fullStr |
The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide |
title_full_unstemmed |
The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide |
title_sort |
aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide |
url |
http://hdl.handle.net/20.500.12110/paper_03407004_v61_n4_p469_ZacariasFluck |
work_keys_str_mv |
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