Spike timing and synaptic plasticity in the premotor pathway of birdsong

The neural circuits of birdsong appear to utilize specific time delays in their operation. In particular, the anterior forebrain pathway (AFP) is implicated in an approximately 40- to 50- ms time delay, ΔT, playing a role in the relative timing of premotor signals from the nucleus HVc to the nucleus...

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Autores principales:	Abarbanel, H.D.I., Gibb, L., Mindlin, G.B., Rabinovich, M.I., Talathi, S.
Formato:	JOUR
Materias:	Behavioral research Biomedical engineering Cells Mathematical models Perturbation techniques Plasticity Anterior forebrain pathway (AFP) Birdsong Motor pathway Synaptic plasticity Neurophysiology Mammalia glutamate receptor action potential animal article biological model brain calcium signaling male nerve cell nerve cell network nerve cell plasticity nerve tract physiology reaction time songbird synaptic transmission time vocalization Action Potentials Animals Brain Calcium Signaling Male Models, Neurological Nerve Net Neural Pathways Neuronal Plasticity Neurons Reaction Time Receptors, Glutamate Songbirds Synaptic Transmission Time Factors Vocalization, Animal
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03401200_v91_n3_p159_Abarbanel
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_03401200_v91_n3_p159_Abarbanel
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spelling	todo:paper_03401200_v91_n3_p159_Abarbanel2023-10-03T15:25:24Z Spike timing and synaptic plasticity in the premotor pathway of birdsong Abarbanel, H.D.I. Gibb, L. Mindlin, G.B. Rabinovich, M.I. Talathi, S. Behavioral research Biomedical engineering Cells Mathematical models Perturbation techniques Plasticity Anterior forebrain pathway (AFP) Birdsong Motor pathway Synaptic plasticity Neurophysiology Mammalia glutamate receptor action potential animal article biological model brain calcium signaling male nerve cell nerve cell network nerve cell plasticity nerve tract physiology reaction time songbird synaptic transmission time vocalization Action Potentials Animals Brain Calcium Signaling Male Models, Neurological Nerve Net Neural Pathways Neuronal Plasticity Neurons Reaction Time Receptors, Glutamate Songbirds Synaptic Transmission Time Factors Vocalization, Animal The neural circuits of birdsong appear to utilize specific time delays in their operation. In particular, the anterior forebrain pathway (AFP) is implicated in an approximately 40- to 50- ms time delay, ΔT, playing a role in the relative timing of premotor signals from the nucleus HVc to the nucleus robust nucleus of the archistratium (RA) and control/learning signals from the nucleus lateral magnocellular nucleus of the anterior neostratium (lMAN) to RA. Using a biophysical model of synaptic plasticity based on experiments on mammalian hippocampal and neocortical pyramidal neurons, we propose an understanding of this ≈ 40- to 50- ms delay. The biophysical model describes the influence of Ca2+ influx into the postsynaptic RA cells through NMDA and AMPA receptors and the induction of LTP and LTD through complex metabolic pathways. The delay, ΔT, between HVc → RA premotor signals and lMAN → RA control/learning signals plays an essential role in determining if synaptic plasticity is induced by signaling from each pathway into RA. If ΔT is substantially larger than 40 ms, no plasticity is induced. If ΔT is much less than 40 ms, only potentiation is expected. If ΔT≈ 40 ms, the sign of synaptic plasticity is sensitive to ΔT. Our results suggest that changes in ΔT may influence learning and maintenance of birdsong. We investigate the robustness of this result to noise and to the removal of the Ca2+ contribution from lMAN → RA NMDA receptors. © Springer-Verlag 2004. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03401200_v91_n3_p159_Abarbanel
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Behavioral research Biomedical engineering Cells Mathematical models Perturbation techniques Plasticity Anterior forebrain pathway (AFP) Birdsong Motor pathway Synaptic plasticity Neurophysiology Mammalia glutamate receptor action potential animal article biological model brain calcium signaling male nerve cell nerve cell network nerve cell plasticity nerve tract physiology reaction time songbird synaptic transmission time vocalization Action Potentials Animals Brain Calcium Signaling Male Models, Neurological Nerve Net Neural Pathways Neuronal Plasticity Neurons Reaction Time Receptors, Glutamate Songbirds Synaptic Transmission Time Factors Vocalization, Animal
spellingShingle	Behavioral research Biomedical engineering Cells Mathematical models Perturbation techniques Plasticity Anterior forebrain pathway (AFP) Birdsong Motor pathway Synaptic plasticity Neurophysiology Mammalia glutamate receptor action potential animal article biological model brain calcium signaling male nerve cell nerve cell network nerve cell plasticity nerve tract physiology reaction time songbird synaptic transmission time vocalization Action Potentials Animals Brain Calcium Signaling Male Models, Neurological Nerve Net Neural Pathways Neuronal Plasticity Neurons Reaction Time Receptors, Glutamate Songbirds Synaptic Transmission Time Factors Vocalization, Animal Abarbanel, H.D.I. Gibb, L. Mindlin, G.B. Rabinovich, M.I. Talathi, S. Spike timing and synaptic plasticity in the premotor pathway of birdsong
topic_facet	Behavioral research Biomedical engineering Cells Mathematical models Perturbation techniques Plasticity Anterior forebrain pathway (AFP) Birdsong Motor pathway Synaptic plasticity Neurophysiology Mammalia glutamate receptor action potential animal article biological model brain calcium signaling male nerve cell nerve cell network nerve cell plasticity nerve tract physiology reaction time songbird synaptic transmission time vocalization Action Potentials Animals Brain Calcium Signaling Male Models, Neurological Nerve Net Neural Pathways Neuronal Plasticity Neurons Reaction Time Receptors, Glutamate Songbirds Synaptic Transmission Time Factors Vocalization, Animal
description	The neural circuits of birdsong appear to utilize specific time delays in their operation. In particular, the anterior forebrain pathway (AFP) is implicated in an approximately 40- to 50- ms time delay, ΔT, playing a role in the relative timing of premotor signals from the nucleus HVc to the nucleus robust nucleus of the archistratium (RA) and control/learning signals from the nucleus lateral magnocellular nucleus of the anterior neostratium (lMAN) to RA. Using a biophysical model of synaptic plasticity based on experiments on mammalian hippocampal and neocortical pyramidal neurons, we propose an understanding of this ≈ 40- to 50- ms delay. The biophysical model describes the influence of Ca2+ influx into the postsynaptic RA cells through NMDA and AMPA receptors and the induction of LTP and LTD through complex metabolic pathways. The delay, ΔT, between HVc → RA premotor signals and lMAN → RA control/learning signals plays an essential role in determining if synaptic plasticity is induced by signaling from each pathway into RA. If ΔT is substantially larger than 40 ms, no plasticity is induced. If ΔT is much less than 40 ms, only potentiation is expected. If ΔT≈ 40 ms, the sign of synaptic plasticity is sensitive to ΔT. Our results suggest that changes in ΔT may influence learning and maintenance of birdsong. We investigate the robustness of this result to noise and to the removal of the Ca2+ contribution from lMAN → RA NMDA receptors. © Springer-Verlag 2004.
format	JOUR
author	Abarbanel, H.D.I. Gibb, L. Mindlin, G.B. Rabinovich, M.I. Talathi, S.
author_facet	Abarbanel, H.D.I. Gibb, L. Mindlin, G.B. Rabinovich, M.I. Talathi, S.
author_sort	Abarbanel, H.D.I.
title	Spike timing and synaptic plasticity in the premotor pathway of birdsong
title_short	Spike timing and synaptic plasticity in the premotor pathway of birdsong
title_full	Spike timing and synaptic plasticity in the premotor pathway of birdsong
title_fullStr	Spike timing and synaptic plasticity in the premotor pathway of birdsong
title_full_unstemmed	Spike timing and synaptic plasticity in the premotor pathway of birdsong
title_sort	spike timing and synaptic plasticity in the premotor pathway of birdsong
url	http://hdl.handle.net/20.500.12110/paper_03401200_v91_n3_p159_Abarbanel
work_keys_str_mv	AT abarbanelhdi spiketimingandsynapticplasticityinthepremotorpathwayofbirdsong AT gibbl spiketimingandsynapticplasticityinthepremotorpathwayofbirdsong AT mindlingb spiketimingandsynapticplasticityinthepremotorpathwayofbirdsong AT rabinovichmi spiketimingandsynapticplasticityinthepremotorpathwayofbirdsong AT talathis spiketimingandsynapticplasticityinthepremotorpathwayofbirdsong
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Spike timing and synaptic plasticity in the premotor pathway of birdsong

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