Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model
Implantation is one of the most regulated processes in human reproduction, by endocrine and immunological systems. Cytokines are involved in embryo-maternal communication and an impaired balance could result in pregnancy loss. Here we investigated the effect of interleukin 1-β on the activity of two...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_03279545_v34_n1_p37_Fontana |
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todo:paper_03279545_v34_n1_p37_Fontana2023-10-03T15:25:17Z Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model Fontana, V.A. Sanchez, M. Cebral, E. Calvo, J.C. Cytokines Embryo implantation Extracellular matrix Placenta gelatinase A gelatinase B interleukin 1beta leptin gelatinase A gelatinase B interleukin 1beta leptin MMP2 protein, human article cell invasion controlled study cytotrophoblast enzyme activity extracellular matrix hormone release human human cell regulatory mechanism biological model cell line drug effect enzymology female metabolism nidation physiology pregnancy secretion trophoblast Cell Line Embryo Implantation Female Humans Interleukin-1beta Leptin Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Models, Biological Pregnancy Trophoblasts Implantation is one of the most regulated processes in human reproduction, by endocrine and immunological systems. Cytokines are involved in embryo-maternal communication and an impaired balance could result in pregnancy loss. Here we investigated the effect of interleukin 1-β on the activity of two important metalloproteinases (MMP-2 and MMP-9) that are involved in extracellular matrix remodeling as well as the secretion of leptin, one of the reproductive hormones actively regulating their activity and secretion. We found that IL-1β activates matrix metalloproteinase activity as well as increases leptin secretion. We propose that this interleukin, through the regulation of leptin, in turn activates matrix metalloproteinases which results in an increased cytotrophoblast invasion. Fil:Fontana, V.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cebral, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Calvo, J.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03279545_v34_n1_p37_Fontana |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cytokines Embryo implantation Extracellular matrix Placenta gelatinase A gelatinase B interleukin 1beta leptin gelatinase A gelatinase B interleukin 1beta leptin MMP2 protein, human article cell invasion controlled study cytotrophoblast enzyme activity extracellular matrix hormone release human human cell regulatory mechanism biological model cell line drug effect enzymology female metabolism nidation physiology pregnancy secretion trophoblast Cell Line Embryo Implantation Female Humans Interleukin-1beta Leptin Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Models, Biological Pregnancy Trophoblasts |
| spellingShingle |
Cytokines Embryo implantation Extracellular matrix Placenta gelatinase A gelatinase B interleukin 1beta leptin gelatinase A gelatinase B interleukin 1beta leptin MMP2 protein, human article cell invasion controlled study cytotrophoblast enzyme activity extracellular matrix hormone release human human cell regulatory mechanism biological model cell line drug effect enzymology female metabolism nidation physiology pregnancy secretion trophoblast Cell Line Embryo Implantation Female Humans Interleukin-1beta Leptin Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Models, Biological Pregnancy Trophoblasts Fontana, V.A. Sanchez, M. Cebral, E. Calvo, J.C. Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model |
| topic_facet |
Cytokines Embryo implantation Extracellular matrix Placenta gelatinase A gelatinase B interleukin 1beta leptin gelatinase A gelatinase B interleukin 1beta leptin MMP2 protein, human article cell invasion controlled study cytotrophoblast enzyme activity extracellular matrix hormone release human human cell regulatory mechanism biological model cell line drug effect enzymology female metabolism nidation physiology pregnancy secretion trophoblast Cell Line Embryo Implantation Female Humans Interleukin-1beta Leptin Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Models, Biological Pregnancy Trophoblasts |
| description |
Implantation is one of the most regulated processes in human reproduction, by endocrine and immunological systems. Cytokines are involved in embryo-maternal communication and an impaired balance could result in pregnancy loss. Here we investigated the effect of interleukin 1-β on the activity of two important metalloproteinases (MMP-2 and MMP-9) that are involved in extracellular matrix remodeling as well as the secretion of leptin, one of the reproductive hormones actively regulating their activity and secretion. We found that IL-1β activates matrix metalloproteinase activity as well as increases leptin secretion. We propose that this interleukin, through the regulation of leptin, in turn activates matrix metalloproteinases which results in an increased cytotrophoblast invasion. |
| format |
JOUR |
| author |
Fontana, V.A. Sanchez, M. Cebral, E. Calvo, J.C. |
| author_facet |
Fontana, V.A. Sanchez, M. Cebral, E. Calvo, J.C. |
| author_sort |
Fontana, V.A. |
| title |
Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model |
| title_short |
Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model |
| title_full |
Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model |
| title_fullStr |
Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model |
| title_full_unstemmed |
Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model |
| title_sort |
interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model |
| url |
http://hdl.handle.net/20.500.12110/paper_03279545_v34_n1_p37_Fontana |
| work_keys_str_mv |
AT fontanava interleukin1bregulatesmetalloproteinaseactivityandleptinsecretioninacytotrophoblastmodel AT sanchezm interleukin1bregulatesmetalloproteinaseactivityandleptinsecretioninacytotrophoblastmodel AT cebrale interleukin1bregulatesmetalloproteinaseactivityandleptinsecretioninacytotrophoblastmodel AT calvojc interleukin1bregulatesmetalloproteinaseactivityandleptinsecretioninacytotrophoblastmodel |
| _version_ |
1782024069398396928 |