Prazosin and stress effect on tumoral growth of 7,12-dimethylbenz[A]anthracene-induced rat mammary tumors
Repeated isolation stress and prazosin effect were evaluated in 7,12-dimethylbenz[A]anthracene (DMBA) mammary tumors. Tumor volume was significantly lower in stressed than in control animals from 10 to 52 days considering day 1 the moment when tumors became palpable and treatment began. Control Praz...
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todo:paper_03276309_v46_n4_p277_Wendel2023-10-03T15:24:58Z Prazosin and stress effect on tumoral growth of 7,12-dimethylbenz[A]anthracene-induced rat mammary tumors Wendel, V. Maris Vazquez, S. Durante, P.C. Lemoine, A.P. Segura, E.T. Calandra, R.S. Luthy, I.A. a-adrenergic receptors mammary cancer prazosin stress 7,12 dimethylbenz[a]anthracene alpha 1 adrenergic receptor estrogen receptor gestagen receptor prazosin unclassified drug animal experiment animal model article breast cancer controlled study drug effect female nonhuman rat stress tumor growth 9,10-Dimethyl-1,2-benzanthracene Adrenergic alpha-Antagonists Animals Female Mammary Neoplasms, Experimental Prazosin Prolactin Rats Rats, Sprague-Dawley Receptors, Estrogen Receptors, Progesterone Stress Repeated isolation stress and prazosin effect were evaluated in 7,12-dimethylbenz[A]anthracene (DMBA) mammary tumors. Tumor volume was significantly lower in stressed than in control animals from 10 to 52 days considering day 1 the moment when tumors became palpable and treatment began. Control Prazosin (0.5 mg/kg) rats showed diminished tumor volume after 40 days. Stress Prazosin curve was similar to stress alone. The proportion of progressing tumors in control was significantly higher than in stressed groups, regardles of Prazosin administration. Body weight gain was similar in every group throughout the experiment. Behavioral studies were performed when stress effect was no longer evident. Grooming and the number of fecal boli were similar in all groups, as well as prolactin serum levels, suggesting that habituation took place. No significant differences were observed between groups for estrogen receptors. However, a greater concentration of progesterone receptors was found in stressed rats, compared to all other groups. We conclude that the decrease of tumor volume provoked by stress could not be reversed by the α1-adrenergic antagonist prazosin. Then, it appears that the main effect of stress is not mediated by the α1-adrenergic receptors. Higher progesterone receptors in stressed rats could explain the differences observed. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03276309_v46_n4_p277_Wendel |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
a-adrenergic receptors mammary cancer prazosin stress 7,12 dimethylbenz[a]anthracene alpha 1 adrenergic receptor estrogen receptor gestagen receptor prazosin unclassified drug animal experiment animal model article breast cancer controlled study drug effect female nonhuman rat stress tumor growth 9,10-Dimethyl-1,2-benzanthracene Adrenergic alpha-Antagonists Animals Female Mammary Neoplasms, Experimental Prazosin Prolactin Rats Rats, Sprague-Dawley Receptors, Estrogen Receptors, Progesterone Stress |
| spellingShingle |
a-adrenergic receptors mammary cancer prazosin stress 7,12 dimethylbenz[a]anthracene alpha 1 adrenergic receptor estrogen receptor gestagen receptor prazosin unclassified drug animal experiment animal model article breast cancer controlled study drug effect female nonhuman rat stress tumor growth 9,10-Dimethyl-1,2-benzanthracene Adrenergic alpha-Antagonists Animals Female Mammary Neoplasms, Experimental Prazosin Prolactin Rats Rats, Sprague-Dawley Receptors, Estrogen Receptors, Progesterone Stress Wendel, V. Maris Vazquez, S. Durante, P.C. Lemoine, A.P. Segura, E.T. Calandra, R.S. Luthy, I.A. Prazosin and stress effect on tumoral growth of 7,12-dimethylbenz[A]anthracene-induced rat mammary tumors |
| topic_facet |
a-adrenergic receptors mammary cancer prazosin stress 7,12 dimethylbenz[a]anthracene alpha 1 adrenergic receptor estrogen receptor gestagen receptor prazosin unclassified drug animal experiment animal model article breast cancer controlled study drug effect female nonhuman rat stress tumor growth 9,10-Dimethyl-1,2-benzanthracene Adrenergic alpha-Antagonists Animals Female Mammary Neoplasms, Experimental Prazosin Prolactin Rats Rats, Sprague-Dawley Receptors, Estrogen Receptors, Progesterone Stress |
| description |
Repeated isolation stress and prazosin effect were evaluated in 7,12-dimethylbenz[A]anthracene (DMBA) mammary tumors. Tumor volume was significantly lower in stressed than in control animals from 10 to 52 days considering day 1 the moment when tumors became palpable and treatment began. Control Prazosin (0.5 mg/kg) rats showed diminished tumor volume after 40 days. Stress Prazosin curve was similar to stress alone. The proportion of progressing tumors in control was significantly higher than in stressed groups, regardles of Prazosin administration. Body weight gain was similar in every group throughout the experiment. Behavioral studies were performed when stress effect was no longer evident. Grooming and the number of fecal boli were similar in all groups, as well as prolactin serum levels, suggesting that habituation took place. No significant differences were observed between groups for estrogen receptors. However, a greater concentration of progesterone receptors was found in stressed rats, compared to all other groups. We conclude that the decrease of tumor volume provoked by stress could not be reversed by the α1-adrenergic antagonist prazosin. Then, it appears that the main effect of stress is not mediated by the α1-adrenergic receptors. Higher progesterone receptors in stressed rats could explain the differences observed. |
| format |
JOUR |
| author |
Wendel, V. Maris Vazquez, S. Durante, P.C. Lemoine, A.P. Segura, E.T. Calandra, R.S. Luthy, I.A. |
| author_facet |
Wendel, V. Maris Vazquez, S. Durante, P.C. Lemoine, A.P. Segura, E.T. Calandra, R.S. Luthy, I.A. |
| author_sort |
Wendel, V. |
| title |
Prazosin and stress effect on tumoral growth of 7,12-dimethylbenz[A]anthracene-induced rat mammary tumors |
| title_short |
Prazosin and stress effect on tumoral growth of 7,12-dimethylbenz[A]anthracene-induced rat mammary tumors |
| title_full |
Prazosin and stress effect on tumoral growth of 7,12-dimethylbenz[A]anthracene-induced rat mammary tumors |
| title_fullStr |
Prazosin and stress effect on tumoral growth of 7,12-dimethylbenz[A]anthracene-induced rat mammary tumors |
| title_full_unstemmed |
Prazosin and stress effect on tumoral growth of 7,12-dimethylbenz[A]anthracene-induced rat mammary tumors |
| title_sort |
prazosin and stress effect on tumoral growth of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors |
| url |
http://hdl.handle.net/20.500.12110/paper_03276309_v46_n4_p277_Wendel |
| work_keys_str_mv |
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