Erythrocyte uroporphyrinogen I synthase in rats treated with the hepatic carcinogen diethylnitrosamine
Uroporphyrinogen I Synthase (URO-S) activity was measured in erythrocytes of female and male rats which had received diethylnitrosamine (DENA) as an inducer of hepatic tumors. Twenty-two weeks after the last dose of the carcinogen, the rats showed statistically significant increases in the URO-S act...
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todo:paper_03276309_v45_n1_p49_DeCalmanovici2023-10-03T15:24:57Z Erythrocyte uroporphyrinogen I synthase in rats treated with the hepatic carcinogen diethylnitrosamine De Calmanovici, R.W. Cochon, A.C. Aldonatti, C.A. Cabral, J.R.P. San Martin De Viale, L.C. diethylnitrosamine hepatic tumors porphyrins rats uroporphyrinogen I synthase diethylnitrosamine porphobilinogen deaminase porphyrin animal cell animal experiment animal model article controlled study enzyme activity erythrocyte female liver tumor male nonhuman rat Animal Carcinoma, Hepatocellular Diethylnitrosamine Erythrocytes Female Hydroxymethylbilane Synthase Liver Neoplasms Male Rats Support, Non-U.S. Gov't Uroporphyrinogen I Synthase (URO-S) activity was measured in erythrocytes of female and male rats which had received diethylnitrosamine (DENA) as an inducer of hepatic tumors. Twenty-two weeks after the last dose of the carcinogen, the rats showed statistically significant increases in the URO-S activity. Differences in the body weight, erythrocyte porphyrin content or the hematocrit between treated and control rats were not found. Fifty percent of female rats and thirty percent of male rats treated with DENA were found to have hepatic tumors but there was no correlation between blood URO-S-activity and tumoral development in spite of the increase in UROS-S activity observed in DENA treated rats. This was observed both in male and female rats. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03276309_v45_n1_p49_DeCalmanovici |
| institution |
Universidad de Buenos Aires |
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I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
diethylnitrosamine hepatic tumors porphyrins rats uroporphyrinogen I synthase diethylnitrosamine porphobilinogen deaminase porphyrin animal cell animal experiment animal model article controlled study enzyme activity erythrocyte female liver tumor male nonhuman rat Animal Carcinoma, Hepatocellular Diethylnitrosamine Erythrocytes Female Hydroxymethylbilane Synthase Liver Neoplasms Male Rats Support, Non-U.S. Gov't |
| spellingShingle |
diethylnitrosamine hepatic tumors porphyrins rats uroporphyrinogen I synthase diethylnitrosamine porphobilinogen deaminase porphyrin animal cell animal experiment animal model article controlled study enzyme activity erythrocyte female liver tumor male nonhuman rat Animal Carcinoma, Hepatocellular Diethylnitrosamine Erythrocytes Female Hydroxymethylbilane Synthase Liver Neoplasms Male Rats Support, Non-U.S. Gov't De Calmanovici, R.W. Cochon, A.C. Aldonatti, C.A. Cabral, J.R.P. San Martin De Viale, L.C. Erythrocyte uroporphyrinogen I synthase in rats treated with the hepatic carcinogen diethylnitrosamine |
| topic_facet |
diethylnitrosamine hepatic tumors porphyrins rats uroporphyrinogen I synthase diethylnitrosamine porphobilinogen deaminase porphyrin animal cell animal experiment animal model article controlled study enzyme activity erythrocyte female liver tumor male nonhuman rat Animal Carcinoma, Hepatocellular Diethylnitrosamine Erythrocytes Female Hydroxymethylbilane Synthase Liver Neoplasms Male Rats Support, Non-U.S. Gov't |
| description |
Uroporphyrinogen I Synthase (URO-S) activity was measured in erythrocytes of female and male rats which had received diethylnitrosamine (DENA) as an inducer of hepatic tumors. Twenty-two weeks after the last dose of the carcinogen, the rats showed statistically significant increases in the URO-S activity. Differences in the body weight, erythrocyte porphyrin content or the hematocrit between treated and control rats were not found. Fifty percent of female rats and thirty percent of male rats treated with DENA were found to have hepatic tumors but there was no correlation between blood URO-S-activity and tumoral development in spite of the increase in UROS-S activity observed in DENA treated rats. This was observed both in male and female rats. |
| format |
JOUR |
| author |
De Calmanovici, R.W. Cochon, A.C. Aldonatti, C.A. Cabral, J.R.P. San Martin De Viale, L.C. |
| author_facet |
De Calmanovici, R.W. Cochon, A.C. Aldonatti, C.A. Cabral, J.R.P. San Martin De Viale, L.C. |
| author_sort |
De Calmanovici, R.W. |
| title |
Erythrocyte uroporphyrinogen I synthase in rats treated with the hepatic carcinogen diethylnitrosamine |
| title_short |
Erythrocyte uroporphyrinogen I synthase in rats treated with the hepatic carcinogen diethylnitrosamine |
| title_full |
Erythrocyte uroporphyrinogen I synthase in rats treated with the hepatic carcinogen diethylnitrosamine |
| title_fullStr |
Erythrocyte uroporphyrinogen I synthase in rats treated with the hepatic carcinogen diethylnitrosamine |
| title_full_unstemmed |
Erythrocyte uroporphyrinogen I synthase in rats treated with the hepatic carcinogen diethylnitrosamine |
| title_sort |
erythrocyte uroporphyrinogen i synthase in rats treated with the hepatic carcinogen diethylnitrosamine |
| url |
http://hdl.handle.net/20.500.12110/paper_03276309_v45_n1_p49_DeCalmanovici |
| work_keys_str_mv |
AT decalmanovicirw erythrocyteuroporphyrinogenisynthaseinratstreatedwiththehepaticcarcinogendiethylnitrosamine AT cochonac erythrocyteuroporphyrinogenisynthaseinratstreatedwiththehepaticcarcinogendiethylnitrosamine AT aldonattica erythrocyteuroporphyrinogenisynthaseinratstreatedwiththehepaticcarcinogendiethylnitrosamine AT cabraljrp erythrocyteuroporphyrinogenisynthaseinratstreatedwiththehepaticcarcinogendiethylnitrosamine AT sanmartindevialelc erythrocyteuroporphyrinogenisynthaseinratstreatedwiththehepaticcarcinogendiethylnitrosamine |
| _version_ |
1782028051321716736 |