Bacillus anthracis: A molecular look at a famous pathogen

Bacillus anthracis, a gram-positive rod belonging to the Bacillus cereus group, has an extremely monomorphic genome, and presents high structural and physiological similarity with B. cereus and Bacillus thuringiensis. In this work, the new molecular methods for the identification and typing of B. an...

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Autores principales:	Pavan, M.E., Pettinari, M.J., Cairó, F., Pavan, E.E., Cataldi, A.A.
Formato:	JOUR
Materias:	Anthrax Bacillus anthracis Genetic diversity Megaplasmids Molecular aspects Virulence factors adhesin bacillibactin bacterial antigen bacterium edema factor lipoprotein petrobactin protein MntA siderophore unclassified drug virulence factor article bacterial membrane bacterial virulence bacterium identification host pathogen interaction lethal gene nonhuman pathogenicity island plasmid species tandem repeat Animals Antigens, Bacterial Bacillus Bacterial Capsules Bacterial Toxins Bacterial Typing Techniques Base Sequence DNA, Bacterial Genomic Islands Humans Membrane Proteins Minisatellite Repeats Molecular Sequence Data Neoplasm Proteins Plasmids Polymorphism, Single Nucleotide Receptors, Cell Surface Sequence Alignment Sequence Homology, Nucleic Acid Virulence Zoonoses
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03257541_v43_n4_p294_Pavan
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_03257541_v43_n4_p294_Pavan2023-10-03T15:24:19Z Bacillus anthracis: A molecular look at a famous pathogen Pavan, M.E. Pettinari, M.J. Cairó, F. Pavan, E.E. Cataldi, A.A. Anthrax Bacillus anthracis Genetic diversity Megaplasmids Molecular aspects Virulence factors adhesin bacillibactin bacterial antigen bacterium edema factor lipoprotein petrobactin protein MntA siderophore unclassified drug virulence factor article Bacillus anthracis bacterial membrane bacterial virulence bacterium identification host pathogen interaction lethal gene nonhuman pathogenicity island plasmid species tandem repeat Animals Anthrax Antigens, Bacterial Bacillus Bacillus anthracis Bacterial Capsules Bacterial Toxins Bacterial Typing Techniques Base Sequence DNA, Bacterial Genomic Islands Humans Membrane Proteins Minisatellite Repeats Molecular Sequence Data Neoplasm Proteins Plasmids Polymorphism, Single Nucleotide Receptors, Cell Surface Sequence Alignment Sequence Homology, Nucleic Acid Virulence Zoonoses Bacillus anthracis, a gram-positive rod belonging to the Bacillus cereus group, has an extremely monomorphic genome, and presents high structural and physiological similarity with B. cereus and Bacillus thuringiensis. In this work, the new molecular methods for the identification and typing of B. anthracis developed in the last years, based on variable number tandem repeats or on genetic differences detected through sequencing, are described. The molecular aspects of traditional virulence factors: capsule, protective antigen, lethal factor and edema factor are described in depth, together with virulence factors recently proposed, such as the siderophores petrobactin and bacillibactin, the S-layer adhesin and the MntA lipoprotein. It is detailed the molecular organization of megaplasmids pXO1 and pXO2, including the pathogenicity island of pXO1. The genetic skeleton of these plasmids has been observed in related species, and this could be attributed to lateral gene transfer. Finally, the two anthrax toxin protective antigen receptors, ANTXR1/TEM8 and ANTXR2/CMG2, essential for the interaction of the pathogen with the host, are presented. The molecular studies performed in recent years have greatly increased knowledge in different aspects of this microorganism and its relationship with the host, but at the same time they have raised new questions about this noted pathogen. Fil:Pettinari, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cataldi, A.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03257541_v43_n4_p294_Pavan
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Anthrax Bacillus anthracis Genetic diversity Megaplasmids Molecular aspects Virulence factors adhesin bacillibactin bacterial antigen bacterium edema factor lipoprotein petrobactin protein MntA siderophore unclassified drug virulence factor article Bacillus anthracis bacterial membrane bacterial virulence bacterium identification host pathogen interaction lethal gene nonhuman pathogenicity island plasmid species tandem repeat Animals Anthrax Antigens, Bacterial Bacillus Bacillus anthracis Bacterial Capsules Bacterial Toxins Bacterial Typing Techniques Base Sequence DNA, Bacterial Genomic Islands Humans Membrane Proteins Minisatellite Repeats Molecular Sequence Data Neoplasm Proteins Plasmids Polymorphism, Single Nucleotide Receptors, Cell Surface Sequence Alignment Sequence Homology, Nucleic Acid Virulence Zoonoses
spellingShingle	Anthrax Bacillus anthracis Genetic diversity Megaplasmids Molecular aspects Virulence factors adhesin bacillibactin bacterial antigen bacterium edema factor lipoprotein petrobactin protein MntA siderophore unclassified drug virulence factor article Bacillus anthracis bacterial membrane bacterial virulence bacterium identification host pathogen interaction lethal gene nonhuman pathogenicity island plasmid species tandem repeat Animals Anthrax Antigens, Bacterial Bacillus Bacillus anthracis Bacterial Capsules Bacterial Toxins Bacterial Typing Techniques Base Sequence DNA, Bacterial Genomic Islands Humans Membrane Proteins Minisatellite Repeats Molecular Sequence Data Neoplasm Proteins Plasmids Polymorphism, Single Nucleotide Receptors, Cell Surface Sequence Alignment Sequence Homology, Nucleic Acid Virulence Zoonoses Pavan, M.E. Pettinari, M.J. Cairó, F. Pavan, E.E. Cataldi, A.A. Bacillus anthracis: A molecular look at a famous pathogen
topic_facet	Anthrax Bacillus anthracis Genetic diversity Megaplasmids Molecular aspects Virulence factors adhesin bacillibactin bacterial antigen bacterium edema factor lipoprotein petrobactin protein MntA siderophore unclassified drug virulence factor article Bacillus anthracis bacterial membrane bacterial virulence bacterium identification host pathogen interaction lethal gene nonhuman pathogenicity island plasmid species tandem repeat Animals Anthrax Antigens, Bacterial Bacillus Bacillus anthracis Bacterial Capsules Bacterial Toxins Bacterial Typing Techniques Base Sequence DNA, Bacterial Genomic Islands Humans Membrane Proteins Minisatellite Repeats Molecular Sequence Data Neoplasm Proteins Plasmids Polymorphism, Single Nucleotide Receptors, Cell Surface Sequence Alignment Sequence Homology, Nucleic Acid Virulence Zoonoses
description	Bacillus anthracis, a gram-positive rod belonging to the Bacillus cereus group, has an extremely monomorphic genome, and presents high structural and physiological similarity with B. cereus and Bacillus thuringiensis. In this work, the new molecular methods for the identification and typing of B. anthracis developed in the last years, based on variable number tandem repeats or on genetic differences detected through sequencing, are described. The molecular aspects of traditional virulence factors: capsule, protective antigen, lethal factor and edema factor are described in depth, together with virulence factors recently proposed, such as the siderophores petrobactin and bacillibactin, the S-layer adhesin and the MntA lipoprotein. It is detailed the molecular organization of megaplasmids pXO1 and pXO2, including the pathogenicity island of pXO1. The genetic skeleton of these plasmids has been observed in related species, and this could be attributed to lateral gene transfer. Finally, the two anthrax toxin protective antigen receptors, ANTXR1/TEM8 and ANTXR2/CMG2, essential for the interaction of the pathogen with the host, are presented. The molecular studies performed in recent years have greatly increased knowledge in different aspects of this microorganism and its relationship with the host, but at the same time they have raised new questions about this noted pathogen.
format	JOUR
author	Pavan, M.E. Pettinari, M.J. Cairó, F. Pavan, E.E. Cataldi, A.A.
author_facet	Pavan, M.E. Pettinari, M.J. Cairó, F. Pavan, E.E. Cataldi, A.A.
author_sort	Pavan, M.E.
title	Bacillus anthracis: A molecular look at a famous pathogen
title_short	Bacillus anthracis: A molecular look at a famous pathogen
title_full	Bacillus anthracis: A molecular look at a famous pathogen
title_fullStr	Bacillus anthracis: A molecular look at a famous pathogen
title_full_unstemmed	Bacillus anthracis: A molecular look at a famous pathogen
title_sort	bacillus anthracis: a molecular look at a famous pathogen
url	http://hdl.handle.net/20.500.12110/paper_03257541_v43_n4_p294_Pavan
work_keys_str_mv	AT pavanme bacillusanthracisamolecularlookatafamouspathogen AT pettinarimj bacillusanthracisamolecularlookatafamouspathogen AT cairof bacillusanthracisamolecularlookatafamouspathogen AT pavanee bacillusanthracisamolecularlookatafamouspathogen AT cataldiaa bacillusanthracisamolecularlookatafamouspathogen
_version_	1782023738812792832

Bacillus anthracis: A molecular look at a famous pathogen

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