Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model

We evaluated the in vitro antiviral activity of meliacin combined with foscarnet on the herpes simplex type 1 (HSV-1) strains F and B2006 (tk-) replication. The effective concentrations for 50% inhibition of HSV-1 (F) were 12.5 micrograms/ml for meliacin and 15.7 micrograms/ml for foscarnet, while f...

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Autores principales:	Barquero, A.A., Villamil, S.M.
Formato:	JOUR
Materias:	antivirus agent foscarnet meliacin peptide vegetable protein animal antibiotic resistance article cell survival Cercopithecus classification comparative study drug effect drug potentiation Herpes simplex virus physiology species difference Vero cell virus replication Animals Antiviral Agents Cell Survival Cercopithecus aethiops Drug Resistance, Microbial Drug Synergism Foscarnet Peptides Plant Proteins Simplexvirus Species Specificity Vero Cells Virus Replication
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03257541_v29_n1_p32_Barquero
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_03257541_v29_n1_p32_Barquero
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spelling	todo:paper_03257541_v29_n1_p32_Barquero2023-10-03T15:24:06Z Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model Barquero, A.A. Villamil, S.M. antivirus agent foscarnet meliacin peptide vegetable protein animal antibiotic resistance article cell survival Cercopithecus classification comparative study drug effect drug potentiation Herpes simplex virus physiology species difference Vero cell virus replication Animals Antiviral Agents Cell Survival Cercopithecus aethiops Drug Resistance, Microbial Drug Synergism Foscarnet Peptides Plant Proteins Simplexvirus Species Specificity Vero Cells Virus Replication We evaluated the in vitro antiviral activity of meliacin combined with foscarnet on the herpes simplex type 1 (HSV-1) strains F and B2006 (tk-) replication. The effective concentrations for 50% inhibition of HSV-1 (F) were 12.5 micrograms/ml for meliacin and 15.7 micrograms/ml for foscarnet, while for HSV-1 (B2006) were 3.1 micrograms/ml and 126 micrograms/ml, respectively. The data were analyzed for quantitation of synergism, additivity, and antagonism of multiple drug effect by the three-dimensional model. Some of the meliacin -foscarnet combinations synergistically inhibited HSV-1 (F) and HSV-1 (B2006) replication in vitro at concentrations that did not reduce cellular viability. Fil:Barquero, A.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03257541_v29_n1_p32_Barquero
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	antivirus agent foscarnet meliacin peptide vegetable protein animal antibiotic resistance article cell survival Cercopithecus classification comparative study drug effect drug potentiation Herpes simplex virus physiology species difference Vero cell virus replication Animals Antiviral Agents Cell Survival Cercopithecus aethiops Drug Resistance, Microbial Drug Synergism Foscarnet Peptides Plant Proteins Simplexvirus Species Specificity Vero Cells Virus Replication
spellingShingle	antivirus agent foscarnet meliacin peptide vegetable protein animal antibiotic resistance article cell survival Cercopithecus classification comparative study drug effect drug potentiation Herpes simplex virus physiology species difference Vero cell virus replication Animals Antiviral Agents Cell Survival Cercopithecus aethiops Drug Resistance, Microbial Drug Synergism Foscarnet Peptides Plant Proteins Simplexvirus Species Specificity Vero Cells Virus Replication Barquero, A.A. Villamil, S.M. Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model
topic_facet	antivirus agent foscarnet meliacin peptide vegetable protein animal antibiotic resistance article cell survival Cercopithecus classification comparative study drug effect drug potentiation Herpes simplex virus physiology species difference Vero cell virus replication Animals Antiviral Agents Cell Survival Cercopithecus aethiops Drug Resistance, Microbial Drug Synergism Foscarnet Peptides Plant Proteins Simplexvirus Species Specificity Vero Cells Virus Replication
description	We evaluated the in vitro antiviral activity of meliacin combined with foscarnet on the herpes simplex type 1 (HSV-1) strains F and B2006 (tk-) replication. The effective concentrations for 50% inhibition of HSV-1 (F) were 12.5 micrograms/ml for meliacin and 15.7 micrograms/ml for foscarnet, while for HSV-1 (B2006) were 3.1 micrograms/ml and 126 micrograms/ml, respectively. The data were analyzed for quantitation of synergism, additivity, and antagonism of multiple drug effect by the three-dimensional model. Some of the meliacin -foscarnet combinations synergistically inhibited HSV-1 (F) and HSV-1 (B2006) replication in vitro at concentrations that did not reduce cellular viability.
format	JOUR
author	Barquero, A.A. Villamil, S.M.
author_facet	Barquero, A.A. Villamil, S.M.
author_sort	Barquero, A.A.
title	Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model
title_short	Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model
title_full	Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model
title_fullStr	Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model
title_full_unstemmed	Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model
title_sort	combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model
url	http://hdl.handle.net/20.500.12110/paper_03257541_v29_n1_p32_Barquero
work_keys_str_mv	AT barqueroaa combinedactivityofmeliacinandfoscarnetagainstdifferentstrainsofherpessimplexvirustype1usingathreedimensionalmodel AT villamilsm combinedactivityofmeliacinandfoscarnetagainstdifferentstrainsofherpessimplexvirustype1usingathreedimensionalmodel
_version_	1782030138751320064

Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model

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