Fibrin network variability

Fibrin is a protein network present in the clot. It can be characterized by its structure, fibers dimensions, ramification degree, porosity, viscoelasticity and deformability. All these properties depend on temperature, ions concentrations and on other plasmatic substances, mainly fibrinogen, thromb...

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Detalles Bibliográficos
Autor principal: Lauricella, A.M.
Formato: JOUR
Materias:
Fibrin
Fibrin properties
Fibrin-formation
Fibrinogen
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03252957_v41_n1_p7_Lauricella
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_03252957_v41_n1_p7_Lauricella
record_format dspace
spelling todo:paper_03252957_v41_n1_p7_Lauricella2023-10-03T15:23:41Z Fibrin network variability Lauricella, A.M. Fibrin Fibrin properties Fibrin-formation Fibrinogen Fibrin is a protein network present in the clot. It can be characterized by its structure, fibers dimensions, ramification degree, porosity, viscoelasticity and deformability. All these properties depend on temperature, ions concentrations and on other plasmatic substances, mainly fibrinogen, thrombin and factor XIII. Greater fibrinogen or thrombin concentrations produce more dense, less porous and shorter fibered-fibrin networks. Fibrinogen alterations can generate abnormal fibrin, with different susceptibility to lysis, while calcium ions increase the fibrin networks' rigidity and porosity. Plasminogen activation and fibrinolysis rate are strongly dependent on the size and the fibrin network architecture. Tight networks are lysed more slowly while, within the same gel, thin fibers are lysed before thick ones. Otherwise, thicker fibers proved to be a better cofactor of plasminogen activation. Taking into account these factors helps understand the different fibrinolytic response, mainly when it is not explained by laboratory studies. Fil:Lauricella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03252957_v41_n1_p7_Lauricella
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Fibrin
Fibrin properties
Fibrin-formation
Fibrinogen
spellingShingle Fibrin
Fibrin properties
Fibrin-formation
Fibrinogen
Lauricella, A.M.
Fibrin network variability
topic_facet Fibrin
Fibrin properties
Fibrin-formation
Fibrinogen
description Fibrin is a protein network present in the clot. It can be characterized by its structure, fibers dimensions, ramification degree, porosity, viscoelasticity and deformability. All these properties depend on temperature, ions concentrations and on other plasmatic substances, mainly fibrinogen, thrombin and factor XIII. Greater fibrinogen or thrombin concentrations produce more dense, less porous and shorter fibered-fibrin networks. Fibrinogen alterations can generate abnormal fibrin, with different susceptibility to lysis, while calcium ions increase the fibrin networks' rigidity and porosity. Plasminogen activation and fibrinolysis rate are strongly dependent on the size and the fibrin network architecture. Tight networks are lysed more slowly while, within the same gel, thin fibers are lysed before thick ones. Otherwise, thicker fibers proved to be a better cofactor of plasminogen activation. Taking into account these factors helps understand the different fibrinolytic response, mainly when it is not explained by laboratory studies.
format JOUR
author Lauricella, A.M.
author_facet Lauricella, A.M.
author_sort Lauricella, A.M.
title Fibrin network variability
title_short Fibrin network variability
title_full Fibrin network variability
title_fullStr Fibrin network variability
title_full_unstemmed Fibrin network variability
title_sort fibrin network variability
url http://hdl.handle.net/20.500.12110/paper_03252957_v41_n1_p7_Lauricella
work_keys_str_mv AT lauricellaam fibrinnetworkvariability
_version_ 1807321101582204928

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