Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma

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Biopsies from human metastatic melanomas were analyzed in order to elucidate the relationship between MCP-1/CCL-2 (monocyte chemoattractant protein-1) chemokine expression by tumor cells, angiogenesis and aggressiveness in tumor development. The chemokine was expressed in 100% of the cases, with het...

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Autores principales:	Gazzaniga, S., Bravo, A.I., Mordoh, J., Wainstok, R.
Formato:	JOUR
Materias:	Angiogenesis Macrophages Melanoma Monocyte chemoattractant protein-1
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03252957_v40_n4_p463_Gazzaniga
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_03252957_v40_n4_p463_Gazzaniga2023-10-03T15:23:41Z Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma Gazzaniga, S. Bravo, A.I. Mordoh, J. Wainstok, R. Angiogenesis Macrophages Melanoma Monocyte chemoattractant protein-1 Biopsies from human metastatic melanomas were analyzed in order to elucidate the relationship between MCP-1/CCL-2 (monocyte chemoattractant protein-1) chemokine expression by tumor cells, angiogenesis and aggressiveness in tumor development. The chemokine was expressed in 100% of the cases, with heterogeneity in the percentage of positive cells within the tumor mass. Tumors presented an important infiltration of macrophages, particularly associated to areas of active angiogenesis. Microvascular development, assessed by immunohistochemistry, correlated with the high percentage of cells expressing MCP-1/CCL-2. There was also significant correlation with vascularization and mitotic index. These results suggest that vascularization could be predictive of more aggressive melanoma metastasis, where the MCP-1/CCL-2 expression would be closely associated to vessel development through macrophages recruitment. Fil:Gazzaniga, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03252957_v40_n4_p463_Gazzaniga
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Angiogenesis Macrophages Melanoma Monocyte chemoattractant protein-1
spellingShingle	Angiogenesis Macrophages Melanoma Monocyte chemoattractant protein-1 Gazzaniga, S. Bravo, A.I. Mordoh, J. Wainstok, R. Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma
topic_facet	Angiogenesis Macrophages Melanoma Monocyte chemoattractant protein-1
description	Biopsies from human metastatic melanomas were analyzed in order to elucidate the relationship between MCP-1/CCL-2 (monocyte chemoattractant protein-1) chemokine expression by tumor cells, angiogenesis and aggressiveness in tumor development. The chemokine was expressed in 100% of the cases, with heterogeneity in the percentage of positive cells within the tumor mass. Tumors presented an important infiltration of macrophages, particularly associated to areas of active angiogenesis. Microvascular development, assessed by immunohistochemistry, correlated with the high percentage of cells expressing MCP-1/CCL-2. There was also significant correlation with vascularization and mitotic index. These results suggest that vascularization could be predictive of more aggressive melanoma metastasis, where the MCP-1/CCL-2 expression would be closely associated to vessel development through macrophages recruitment.
format	JOUR
author	Gazzaniga, S. Bravo, A.I. Mordoh, J. Wainstok, R.
author_facet	Gazzaniga, S. Bravo, A.I. Mordoh, J. Wainstok, R.
author_sort	Gazzaniga, S.
title	Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma
title_short	Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma
title_full	Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma
title_fullStr	Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma
title_full_unstemmed	Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma
title_sort	monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma
url	http://hdl.handle.net/20.500.12110/paper_03252957_v40_n4_p463_Gazzaniga
work_keys_str_mv	AT gazzanigas monocytechemoattractantproteincorrelateswithangiogenesisinmetastaticmelanoma AT bravoai monocytechemoattractantproteincorrelateswithangiogenesisinmetastaticmelanoma AT mordohj monocytechemoattractantproteincorrelateswithangiogenesisinmetastaticmelanoma AT wainstokr monocytechemoattractantproteincorrelateswithangiogenesisinmetastaticmelanoma
_version_	1807316074654334976

Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma

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