Alteraciones en la enzimología de la productión de aldosterona

The late pathway of aldosterone production (conversion of 11-deoxycorticosterone into aldosterone) in mitochondria of rat adrenal zona glomerulosa is catalyzed by CYP11B2. In zona fasciculate, CYP11B1 transforms 11-deoxycorticosterone into corticosterone or 18-hydroxy-11-deoxycorticosterone. Homolog...

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Autores principales: Matkovic, L.B., Gómez-Sánchez, C.E., Lantos, C.P., Cozza, E.N.
Formato: JOUR
Materias:
Adrenal
Aldoaterone
Aldosteronism
Cytochrome p450
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03252957_v32_n1_p3_Matkovic
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_03252957_v32_n1_p3_Matkovic
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spelling todo:paper_03252957_v32_n1_p3_Matkovic2023-10-03T15:23:33Z Alteraciones en la enzimología de la productión de aldosterona Matkovic, L.B. Gómez-Sánchez, C.E. Lantos, C.P. Cozza, E.N. Adrenal Aldoaterone Aldosteronism Cytochrome p450 The late pathway of aldosterone production (conversion of 11-deoxycorticosterone into aldosterone) in mitochondria of rat adrenal zona glomerulosa is catalyzed by CYP11B2. In zona fasciculate, CYP11B1 transforms 11-deoxycorticosterone into corticosterone or 18-hydroxy-11-deoxycorticosterone. Homology between CYP11B1 and CYP11B2 is very high, both genes being located in tandem in chromosome 8q22. Mutations in the CYP11B2 gene and genetic recombination between CYP11B1 and CYP11B2 could be responsible for alterations in the enzymology of aldosterone production, raising a new nomenclature and explanations for the deficiencies primarily described, as CMOI and CMOII. Fil:Matkovic, L.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cozza, E.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03252957_v32_n1_p3_Matkovic
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Adrenal
Aldoaterone
Aldosteronism
Cytochrome p450
spellingShingle Adrenal
Aldoaterone
Aldosteronism
Cytochrome p450
Matkovic, L.B.
Gómez-Sánchez, C.E.
Lantos, C.P.
Cozza, E.N.
Alteraciones en la enzimología de la productión de aldosterona
topic_facet Adrenal
Aldoaterone
Aldosteronism
Cytochrome p450
description The late pathway of aldosterone production (conversion of 11-deoxycorticosterone into aldosterone) in mitochondria of rat adrenal zona glomerulosa is catalyzed by CYP11B2. In zona fasciculate, CYP11B1 transforms 11-deoxycorticosterone into corticosterone or 18-hydroxy-11-deoxycorticosterone. Homology between CYP11B1 and CYP11B2 is very high, both genes being located in tandem in chromosome 8q22. Mutations in the CYP11B2 gene and genetic recombination between CYP11B1 and CYP11B2 could be responsible for alterations in the enzymology of aldosterone production, raising a new nomenclature and explanations for the deficiencies primarily described, as CMOI and CMOII.
format JOUR
author Matkovic, L.B.
Gómez-Sánchez, C.E.
Lantos, C.P.
Cozza, E.N.
author_facet Matkovic, L.B.
Gómez-Sánchez, C.E.
Lantos, C.P.
Cozza, E.N.
author_sort Matkovic, L.B.
title Alteraciones en la enzimología de la productión de aldosterona
title_short Alteraciones en la enzimología de la productión de aldosterona
title_full Alteraciones en la enzimología de la productión de aldosterona
title_fullStr Alteraciones en la enzimología de la productión de aldosterona
title_full_unstemmed Alteraciones en la enzimología de la productión de aldosterona
title_sort alteraciones en la enzimología de la productión de aldosterona
url http://hdl.handle.net/20.500.12110/paper_03252957_v32_n1_p3_Matkovic
work_keys_str_mv AT matkoviclb alteracionesenlaenzimologiadelaproductiondealdosterona
AT gomezsanchezce alteracionesenlaenzimologiadelaproductiondealdosterona
AT lantoscp alteracionesenlaenzimologiadelaproductiondealdosterona
AT cozzaen alteracionesenlaenzimologiadelaproductiondealdosterona
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