Effect of synthetic steroids on GABAA receptor binding in rat brain

Neuroactive steroids, like allopregnanolone (A) and pregnanolone (P), bind to specifics sites on the GABAA receptor complex and modulate receptor function. They are capable to inhibit or stimulate the binding of GABAA receptor-specific ligands, like t-butyl-bicyclophosphorothionate, flunitrazepam an...

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Detalles Bibliográficos
Autores principales: Rey, M., Veleiro, A.S., Ghini, A.A., Kruse, M.S., Burton, G., Coirini, H.
Formato: JOUR
Materias:
Autoradiography
Cerebral cortex
GABAA receptor
Hippocampus
Neurosteroids
Synthetic steroids
3alpha hydroxy 2beta, 19 epoxy 5alpha pregnan 20 one
3alpha hydroxy 5alpha pregnan 20 one
3alpha hydroxy 6,19 epoxypregn 4 ene 20 one
4 aminobutyric acid A receptor
eltanolone
steroid
unclassified drug
3-hydroxy-2,19-epoxypregnan-20-one
3-hydroxy-6,19-epoxypregn-4-ene-20-one
4 aminobutyric acid A receptor stimulating agent
flunitrazepam
fused heterocyclic rings
muscimol
protein binding
sulfur
tert-butylbicyclophosphorothionate
tritium
animal experiment
animal tissue
Article
autoradiography
brain cortex
brain radiography
central nervous system
controlled study
drug activity
drug brain level
drug receptor binding
drug structure
hippocampus
in vitro study
male
neuroimaging
nonhuman
rat
stratum radiatum
synaptosome
analogs and derivatives
animal
binding competition
chemistry
drug effects
metabolism
Sprague Dawley rat
Animals
Bicyclo Compounds, Heterocyclic
Binding, Competitive
Cerebral Cortex
Flunitrazepam
GABA-A Receptor Agonists
Male
Muscimol
Pregnanolone
Protein Binding
Rats, Sprague-Dawley
Receptors, GABA-A
Sulfur Radioisotopes
Tritium
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03064522_v290_n_p138_Rey
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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