Angiotensin II and the transcription factor Rel/NF-κB link environmental water shortage with memory improvement
One of the essential requirements even in the most ancient life forms is to be able to preserve body fluid medium. In line with such requirement, animals need to perform different behaviors to cope with water shortages. As angiotensin II (ANGII) is involved on a widespread range of functions in vert...
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todo:paper_03064522_v115_n4_p1079_Frenkel2023-10-03T15:22:20Z Angiotensin II and the transcription factor Rel/NF-κB link environmental water shortage with memory improvement Frenkel, L. Freudenthal, R. Romano, A. Nahmod, V.E Maldonado, H. Delorenzi, A. Angiotensin Invertebrate Memory Neuropeptide NF-κB osmoregulation angiotensin angiotensin receptor antagonist immunoglobulin enhancer binding protein saralasin sodium transcription factor transcription factor Rel unclassified drug animal experiment animal tissue article cognition controlled study crab environmental exposure immunoreactivity male memory consolidation nonhuman priority journal protein function sodium blood level One of the essential requirements even in the most ancient life forms is to be able to preserve body fluid medium. In line with such requirement, animals need to perform different behaviors to cope with water shortages. As angiotensin II (ANGII) is involved on a widespread range of functions in vertebrates, including memory modulation, an integrative role, in response to an environmental water shortage, has been envisioned. Previous work on the semi-terrestrial and brackish-water crab Chasmagnathus granulatus showed that endogenous ANGII enhanced an associative long-term memory and, in addition, that high salinity environment induces both an increase of brain ANGII levels and memory improvement. Here, we show that in the crab Chasmagnathus air exposure transiently increases blood sodium concentration, significantly increases brain ANGII immunoreactivity, and has a facilitatory effect on memory that is abolished by a non-selective ANGII receptor antagonist, saralasin. Furthermore, Rel/NF-κB, a transcription factor activated by ANGII in mammals and during memory consolidation in Chasmagnathus brain, is induced in the crab's brain by air exposure. Moreover, nuclear brain NF-κB is activated by ANGII, and this effect is reversed by saralasin. Our results constitute the first demonstration in an invertebrate that cognitive functions are modulated by an environmental stimulus through a neuropeptide and give evolutionary support to the role of angiotensins in memory processes. Moreover, these results suggest that angiotensinergic system is preserved across evolution not only in its structure and molecular mechanisms, but also in its capability of coordinating specific adaptative responses. © 2002 IBRO. Published by Elsevier Science Ltd. All rights reserved. Fil:Frenkel, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Freudenthal, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Delorenzi, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03064522_v115_n4_p1079_Frenkel |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Angiotensin Invertebrate Memory Neuropeptide NF-κB osmoregulation angiotensin angiotensin receptor antagonist immunoglobulin enhancer binding protein saralasin sodium transcription factor transcription factor Rel unclassified drug animal experiment animal tissue article cognition controlled study crab environmental exposure immunoreactivity male memory consolidation nonhuman priority journal protein function sodium blood level |
| spellingShingle |
Angiotensin Invertebrate Memory Neuropeptide NF-κB osmoregulation angiotensin angiotensin receptor antagonist immunoglobulin enhancer binding protein saralasin sodium transcription factor transcription factor Rel unclassified drug animal experiment animal tissue article cognition controlled study crab environmental exposure immunoreactivity male memory consolidation nonhuman priority journal protein function sodium blood level Frenkel, L. Freudenthal, R. Romano, A. Nahmod, V.E Maldonado, H. Delorenzi, A. Angiotensin II and the transcription factor Rel/NF-κB link environmental water shortage with memory improvement |
| topic_facet |
Angiotensin Invertebrate Memory Neuropeptide NF-κB osmoregulation angiotensin angiotensin receptor antagonist immunoglobulin enhancer binding protein saralasin sodium transcription factor transcription factor Rel unclassified drug animal experiment animal tissue article cognition controlled study crab environmental exposure immunoreactivity male memory consolidation nonhuman priority journal protein function sodium blood level |
| description |
One of the essential requirements even in the most ancient life forms is to be able to preserve body fluid medium. In line with such requirement, animals need to perform different behaviors to cope with water shortages. As angiotensin II (ANGII) is involved on a widespread range of functions in vertebrates, including memory modulation, an integrative role, in response to an environmental water shortage, has been envisioned. Previous work on the semi-terrestrial and brackish-water crab Chasmagnathus granulatus showed that endogenous ANGII enhanced an associative long-term memory and, in addition, that high salinity environment induces both an increase of brain ANGII levels and memory improvement. Here, we show that in the crab Chasmagnathus air exposure transiently increases blood sodium concentration, significantly increases brain ANGII immunoreactivity, and has a facilitatory effect on memory that is abolished by a non-selective ANGII receptor antagonist, saralasin. Furthermore, Rel/NF-κB, a transcription factor activated by ANGII in mammals and during memory consolidation in Chasmagnathus brain, is induced in the crab's brain by air exposure. Moreover, nuclear brain NF-κB is activated by ANGII, and this effect is reversed by saralasin. Our results constitute the first demonstration in an invertebrate that cognitive functions are modulated by an environmental stimulus through a neuropeptide and give evolutionary support to the role of angiotensins in memory processes. Moreover, these results suggest that angiotensinergic system is preserved across evolution not only in its structure and molecular mechanisms, but also in its capability of coordinating specific adaptative responses. © 2002 IBRO. Published by Elsevier Science Ltd. All rights reserved. |
| format |
JOUR |
| author |
Frenkel, L. Freudenthal, R. Romano, A. Nahmod, V.E Maldonado, H. Delorenzi, A. |
| author_facet |
Frenkel, L. Freudenthal, R. Romano, A. Nahmod, V.E Maldonado, H. Delorenzi, A. |
| author_sort |
Frenkel, L. |
| title |
Angiotensin II and the transcription factor Rel/NF-κB link environmental water shortage with memory improvement |
| title_short |
Angiotensin II and the transcription factor Rel/NF-κB link environmental water shortage with memory improvement |
| title_full |
Angiotensin II and the transcription factor Rel/NF-κB link environmental water shortage with memory improvement |
| title_fullStr |
Angiotensin II and the transcription factor Rel/NF-κB link environmental water shortage with memory improvement |
| title_full_unstemmed |
Angiotensin II and the transcription factor Rel/NF-κB link environmental water shortage with memory improvement |
| title_sort |
angiotensin ii and the transcription factor rel/nf-κb link environmental water shortage with memory improvement |
| url |
http://hdl.handle.net/20.500.12110/paper_03064522_v115_n4_p1079_Frenkel |
| work_keys_str_mv |
AT frenkell angiotensiniiandthetranscriptionfactorrelnfkblinkenvironmentalwatershortagewithmemoryimprovement AT freudenthalr angiotensiniiandthetranscriptionfactorrelnfkblinkenvironmentalwatershortagewithmemoryimprovement AT romanoa angiotensiniiandthetranscriptionfactorrelnfkblinkenvironmentalwatershortagewithmemoryimprovement AT nahmodve angiotensiniiandthetranscriptionfactorrelnfkblinkenvironmentalwatershortagewithmemoryimprovement AT maldonadoh angiotensiniiandthetranscriptionfactorrelnfkblinkenvironmentalwatershortagewithmemoryimprovement AT delorenzia angiotensiniiandthetranscriptionfactorrelnfkblinkenvironmentalwatershortagewithmemoryimprovement |
| _version_ |
1807314660560470016 |