Effect of chronic administration of verapamil in Duchenne muscular dystrophy
1. 1. In DMD patients the effect of chronic treatment with verapamil was investigated in the p-nitrophenylphosphatase from erythrocytes, the CK and LDH in serum and the functional activity of the muscle. 2. 2. A different behaviour in the p-nitrophenylphosphatase from untreated compared to treated D...
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todo:paper_03063623_v21_n6_p939_Garcia2023-10-03T15:22:12Z Effect of chronic administration of verapamil in Duchenne muscular dystrophy Garcia, A.M. Goldemberg, A.L. Fernández, H. Fortunato, M. Ricci, L. Trucco, R.E. 4 nitrophenylphosphatase erythrocyte enzyme verapamil article child clinical article controlled study creatine kinase blood level duchenne muscular dystrophy human lactate dehydrogenase blood level male oral drug administration priority journal 4-Nitrophenylphosphatase Adolescent Alkaline Phosphatase Child Child, Preschool Comparative Study Creatine Kinase Erythrocytes Human Lactate Dehydrogenase Male Muscles Muscular Dystrophies Support, Non-U.S. Gov't Time Factors Verapamil 1. 1. In DMD patients the effect of chronic treatment with verapamil was investigated in the p-nitrophenylphosphatase from erythrocytes, the CK and LDH in serum and the functional activity of the muscle. 2. 2. A different behaviour in the p-nitrophenylphosphatase from untreated compared to treated DMD patients and controls is supported by the following findings: (a) values of "n" altered in F- inhibition of the enzyme with Hill coefficients -1.43, -2.18 and -2.19; (b) Arrhenius plots between 16 and 40°C with inflection points for the enzyme from treated DMD patients and controls and not from untreated DMD patients. 3. 3. Although CK and LDH in serum and the muscular evaluation showed no statistical difference between both groups, evidence is presented that in treated DMD patients the interaction membrane-enzyme is different from untreated DMD patients. © 1990. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03063623_v21_n6_p939_Garcia |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
4 nitrophenylphosphatase erythrocyte enzyme verapamil article child clinical article controlled study creatine kinase blood level duchenne muscular dystrophy human lactate dehydrogenase blood level male oral drug administration priority journal 4-Nitrophenylphosphatase Adolescent Alkaline Phosphatase Child Child, Preschool Comparative Study Creatine Kinase Erythrocytes Human Lactate Dehydrogenase Male Muscles Muscular Dystrophies Support, Non-U.S. Gov't Time Factors Verapamil |
spellingShingle |
4 nitrophenylphosphatase erythrocyte enzyme verapamil article child clinical article controlled study creatine kinase blood level duchenne muscular dystrophy human lactate dehydrogenase blood level male oral drug administration priority journal 4-Nitrophenylphosphatase Adolescent Alkaline Phosphatase Child Child, Preschool Comparative Study Creatine Kinase Erythrocytes Human Lactate Dehydrogenase Male Muscles Muscular Dystrophies Support, Non-U.S. Gov't Time Factors Verapamil Garcia, A.M. Goldemberg, A.L. Fernández, H. Fortunato, M. Ricci, L. Trucco, R.E. Effect of chronic administration of verapamil in Duchenne muscular dystrophy |
topic_facet |
4 nitrophenylphosphatase erythrocyte enzyme verapamil article child clinical article controlled study creatine kinase blood level duchenne muscular dystrophy human lactate dehydrogenase blood level male oral drug administration priority journal 4-Nitrophenylphosphatase Adolescent Alkaline Phosphatase Child Child, Preschool Comparative Study Creatine Kinase Erythrocytes Human Lactate Dehydrogenase Male Muscles Muscular Dystrophies Support, Non-U.S. Gov't Time Factors Verapamil |
description |
1. 1. In DMD patients the effect of chronic treatment with verapamil was investigated in the p-nitrophenylphosphatase from erythrocytes, the CK and LDH in serum and the functional activity of the muscle. 2. 2. A different behaviour in the p-nitrophenylphosphatase from untreated compared to treated DMD patients and controls is supported by the following findings: (a) values of "n" altered in F- inhibition of the enzyme with Hill coefficients -1.43, -2.18 and -2.19; (b) Arrhenius plots between 16 and 40°C with inflection points for the enzyme from treated DMD patients and controls and not from untreated DMD patients. 3. 3. Although CK and LDH in serum and the muscular evaluation showed no statistical difference between both groups, evidence is presented that in treated DMD patients the interaction membrane-enzyme is different from untreated DMD patients. © 1990. |
format |
JOUR |
author |
Garcia, A.M. Goldemberg, A.L. Fernández, H. Fortunato, M. Ricci, L. Trucco, R.E. |
author_facet |
Garcia, A.M. Goldemberg, A.L. Fernández, H. Fortunato, M. Ricci, L. Trucco, R.E. |
author_sort |
Garcia, A.M. |
title |
Effect of chronic administration of verapamil in Duchenne muscular dystrophy |
title_short |
Effect of chronic administration of verapamil in Duchenne muscular dystrophy |
title_full |
Effect of chronic administration of verapamil in Duchenne muscular dystrophy |
title_fullStr |
Effect of chronic administration of verapamil in Duchenne muscular dystrophy |
title_full_unstemmed |
Effect of chronic administration of verapamil in Duchenne muscular dystrophy |
title_sort |
effect of chronic administration of verapamil in duchenne muscular dystrophy |
url |
http://hdl.handle.net/20.500.12110/paper_03063623_v21_n6_p939_Garcia |
work_keys_str_mv |
AT garciaam effectofchronicadministrationofverapamilinduchennemusculardystrophy AT goldembergal effectofchronicadministrationofverapamilinduchennemusculardystrophy AT fernandezh effectofchronicadministrationofverapamilinduchennemusculardystrophy AT fortunatom effectofchronicadministrationofverapamilinduchennemusculardystrophy AT riccil effectofchronicadministrationofverapamilinduchennemusculardystrophy AT truccore effectofchronicadministrationofverapamilinduchennemusculardystrophy |
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