In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway
1. The effect of colchicine, vincristin and griseofulvin (GRIS) on the porphyrinogenic action of 2-allyl-2-isopropylacetamide (AIA) and veronal was studied in vivo and using the in vitro experimental model of tissue explant cultures. 2. Complete prevention by colchicine was found in liver and heart...
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todo:paper_03063623_v21_n4_p423_Afonso2023-10-03T15:22:11Z In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway Afonso, S.G. Polo, C.F. Navone, N.M. Vazquez, E.S. Buzaleh, A.M. Schoua, E. Alcira Maria, d.C.B. allylisopropylacetamide barbital colchicine griseofulvin lactate dehydrogenase porphyrin vincristine animal cell animal experiment article heart heme synthesis intraperitoneal drug administration liver male mouse nonhuman porphyria priority journal skin tissue culture 5-Aminolevulinate Synthetase Allylisopropylacetamide Animal Colchicine Enzyme Induction Griseofulvin Heme In Vitro Lactate Dehydrogenase Male Mice Porphyrins Support, Non-U.S. Gov't Vincristine 1. The effect of colchicine, vincristin and griseofulvin (GRIS) on the porphyrinogenic action of 2-allyl-2-isopropylacetamide (AIA) and veronal was studied in vivo and using the in vitro experimental model of tissue explant cultures. 2. Complete prevention by colchicine was found in liver and heart explant from animals treated with AIA and veronal. 3. Vincristin, GRIS and colchicine reversed AIA induction in liver explants, however reversal was partial or nil in skin and heart explants depending on the antimitotic and the tissue. 4. The usefulness of the combination of the in vivo experimental model and the in vitro explant tissue culture model, for this kind of studies is emphasized. © 1990. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03063623_v21_n4_p423_Afonso |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
allylisopropylacetamide barbital colchicine griseofulvin lactate dehydrogenase porphyrin vincristine animal cell animal experiment article heart heme synthesis intraperitoneal drug administration liver male mouse nonhuman porphyria priority journal skin tissue culture 5-Aminolevulinate Synthetase Allylisopropylacetamide Animal Colchicine Enzyme Induction Griseofulvin Heme In Vitro Lactate Dehydrogenase Male Mice Porphyrins Support, Non-U.S. Gov't Vincristine |
| spellingShingle |
allylisopropylacetamide barbital colchicine griseofulvin lactate dehydrogenase porphyrin vincristine animal cell animal experiment article heart heme synthesis intraperitoneal drug administration liver male mouse nonhuman porphyria priority journal skin tissue culture 5-Aminolevulinate Synthetase Allylisopropylacetamide Animal Colchicine Enzyme Induction Griseofulvin Heme In Vitro Lactate Dehydrogenase Male Mice Porphyrins Support, Non-U.S. Gov't Vincristine Afonso, S.G. Polo, C.F. Navone, N.M. Vazquez, E.S. Buzaleh, A.M. Schoua, E. Alcira Maria, d.C.B. In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway |
| topic_facet |
allylisopropylacetamide barbital colchicine griseofulvin lactate dehydrogenase porphyrin vincristine animal cell animal experiment article heart heme synthesis intraperitoneal drug administration liver male mouse nonhuman porphyria priority journal skin tissue culture 5-Aminolevulinate Synthetase Allylisopropylacetamide Animal Colchicine Enzyme Induction Griseofulvin Heme In Vitro Lactate Dehydrogenase Male Mice Porphyrins Support, Non-U.S. Gov't Vincristine |
| description |
1. The effect of colchicine, vincristin and griseofulvin (GRIS) on the porphyrinogenic action of 2-allyl-2-isopropylacetamide (AIA) and veronal was studied in vivo and using the in vitro experimental model of tissue explant cultures. 2. Complete prevention by colchicine was found in liver and heart explant from animals treated with AIA and veronal. 3. Vincristin, GRIS and colchicine reversed AIA induction in liver explants, however reversal was partial or nil in skin and heart explants depending on the antimitotic and the tissue. 4. The usefulness of the combination of the in vivo experimental model and the in vitro explant tissue culture model, for this kind of studies is emphasized. © 1990. |
| format |
JOUR |
| author |
Afonso, S.G. Polo, C.F. Navone, N.M. Vazquez, E.S. Buzaleh, A.M. Schoua, E. Alcira Maria, d.C.B. |
| author_facet |
Afonso, S.G. Polo, C.F. Navone, N.M. Vazquez, E.S. Buzaleh, A.M. Schoua, E. Alcira Maria, d.C.B. |
| author_sort |
Afonso, S.G. |
| title |
In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway |
| title_short |
In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway |
| title_full |
In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway |
| title_fullStr |
In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway |
| title_full_unstemmed |
In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway |
| title_sort |
in vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway |
| url |
http://hdl.handle.net/20.500.12110/paper_03063623_v21_n4_p423_Afonso |
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