Cyclic AMP as an intracellular messenger of gonadotrophin-induced steroidogenesis during the development of the embryonic chick ovary

1. 1. Ovine luteinizing hormone (LH) stimulates cyclic AMP (cAMP) and progeterone production (P) throughout late ontogeny of the chick ovary and cAMP mimicks LH in stimulating P secretion but: 2. 2. P/cAMP ratios are lower at the earliest stages than at hatching, LH enhancing this tendency. 3. 3. Im...

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Detalles Bibliográficos
Autores principales: González, C.B., Cantore, M.L., Lantos, C.P., Passeron, S.
Formato: JOUR
Materias:
cyclic amp
luteinizing hormone
progesterone
radioisotope
animal cell
article
chicken
nonhuman
ovary
priority journal
Animal
Bucladesine
Chick Embryo
Cyclic AMP
Female
Forskolin
Luteinizing Hormone
Ovary
Progesterone
Second Messenger Systems
Steroids
Support, Non-U.S. Gov't
Animalia
Gallus gallus
Ovis
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03050491_v96_n1_p53_Gonzalez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:1. 1. Ovine luteinizing hormone (LH) stimulates cyclic AMP (cAMP) and progeterone production (P) throughout late ontogeny of the chick ovary and cAMP mimicks LH in stimulating P secretion but: 2. 2. P/cAMP ratios are lower at the earliest stages than at hatching, LH enhancing this tendency. 3. 3. Immediately before hatching, on day 19 time-courses of LH stimulations of cAMP and P are different. 4. (4) cAMP and P respond differently to increasing doses of LH but similarly to increasing doses of forskolin. 5. (5) 1.5 mM dibutyryl cAMP (I) and 100 ng LH (II) increase P maximally, 2.5- and 3.3-fold respectively, but a mixture (I + II) increases P 7.5-fold. © 1990.

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