Diurnal changes in melatonin binding sites of hamster and rat brains. Correlation with neuroendocrine responsiveness to melatonin
A diurnal variation in neuroendocrine sensitivity to melatonin is known to occur in hamsters and rats. The present experiments were carried out to examine the possibility that affinity and/or number of melatonin binding sites in brain could change accordingly at the two times when exogenous melatoni...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_03043940_v15_n2-3_p259_Vacas |
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todo:paper_03043940_v15_n2-3_p259_Vacas2023-10-03T15:20:16Z Diurnal changes in melatonin binding sites of hamster and rat brains. Correlation with neuroendocrine responsiveness to melatonin Vacas, M.I. Cardinali, D.P. tritium animal experiment bernard soulier disease brain central nervous system circadian rhythm drug binding hamster in vitro study melatonin h 3 radioimmunoassay rat Animal Brain Chemistry Circadian Rhythm Comparative Study Hamsters Light Male Melatonin Rats Receptors, Cell Surface Species Specificity A diurnal variation in neuroendocrine sensitivity to melatonin is known to occur in hamsters and rats. The present experiments were carried out to examine the possibility that affinity and/or number of melatonin binding sites in brain could change accordingly at the two times when exogenous melatonin is known to be ineffective or effective to produce neuroendocrine changes, i.e., at 07 : 00 or 20 : 00 h (lights on from 07 : 00 to 21 : 00 h daily). The number of melatonin binding sites in hamster and rat brains was at 20 : 00 h 34-56% higher than at 07 : 00 h, without changing their affinity towards [3H]melatonin (hamster: Kd = 53 nM; rat: Kd = 73-77 nM). These alterations in melatonin receptor density may play a role in daily changes in sensitivity to the exogenous methoxyindole. © 1979. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03043940_v15_n2-3_p259_Vacas |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
tritium animal experiment bernard soulier disease brain central nervous system circadian rhythm drug binding hamster in vitro study melatonin h 3 radioimmunoassay rat Animal Brain Chemistry Circadian Rhythm Comparative Study Hamsters Light Male Melatonin Rats Receptors, Cell Surface Species Specificity |
| spellingShingle |
tritium animal experiment bernard soulier disease brain central nervous system circadian rhythm drug binding hamster in vitro study melatonin h 3 radioimmunoassay rat Animal Brain Chemistry Circadian Rhythm Comparative Study Hamsters Light Male Melatonin Rats Receptors, Cell Surface Species Specificity Vacas, M.I. Cardinali, D.P. Diurnal changes in melatonin binding sites of hamster and rat brains. Correlation with neuroendocrine responsiveness to melatonin |
| topic_facet |
tritium animal experiment bernard soulier disease brain central nervous system circadian rhythm drug binding hamster in vitro study melatonin h 3 radioimmunoassay rat Animal Brain Chemistry Circadian Rhythm Comparative Study Hamsters Light Male Melatonin Rats Receptors, Cell Surface Species Specificity |
| description |
A diurnal variation in neuroendocrine sensitivity to melatonin is known to occur in hamsters and rats. The present experiments were carried out to examine the possibility that affinity and/or number of melatonin binding sites in brain could change accordingly at the two times when exogenous melatonin is known to be ineffective or effective to produce neuroendocrine changes, i.e., at 07 : 00 or 20 : 00 h (lights on from 07 : 00 to 21 : 00 h daily). The number of melatonin binding sites in hamster and rat brains was at 20 : 00 h 34-56% higher than at 07 : 00 h, without changing their affinity towards [3H]melatonin (hamster: Kd = 53 nM; rat: Kd = 73-77 nM). These alterations in melatonin receptor density may play a role in daily changes in sensitivity to the exogenous methoxyindole. © 1979. |
| format |
JOUR |
| author |
Vacas, M.I. Cardinali, D.P. |
| author_facet |
Vacas, M.I. Cardinali, D.P. |
| author_sort |
Vacas, M.I. |
| title |
Diurnal changes in melatonin binding sites of hamster and rat brains. Correlation with neuroendocrine responsiveness to melatonin |
| title_short |
Diurnal changes in melatonin binding sites of hamster and rat brains. Correlation with neuroendocrine responsiveness to melatonin |
| title_full |
Diurnal changes in melatonin binding sites of hamster and rat brains. Correlation with neuroendocrine responsiveness to melatonin |
| title_fullStr |
Diurnal changes in melatonin binding sites of hamster and rat brains. Correlation with neuroendocrine responsiveness to melatonin |
| title_full_unstemmed |
Diurnal changes in melatonin binding sites of hamster and rat brains. Correlation with neuroendocrine responsiveness to melatonin |
| title_sort |
diurnal changes in melatonin binding sites of hamster and rat brains. correlation with neuroendocrine responsiveness to melatonin |
| url |
http://hdl.handle.net/20.500.12110/paper_03043940_v15_n2-3_p259_Vacas |
| work_keys_str_mv |
AT vacasmi diurnalchangesinmelatoninbindingsitesofhamsterandratbrainscorrelationwithneuroendocrineresponsivenesstomelatonin AT cardinalidp diurnalchangesinmelatoninbindingsitesofhamsterandratbrainscorrelationwithneuroendocrineresponsivenesstomelatonin |
| _version_ |
1807314776674533376 |