Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats
The response of female BDVI rats bearing diethylnitrosamine (DENA)-induced hepatic tumors to the porphyrinogenic action of hexachlorobenzene (HCB) was studied. (1) The heme pathway operates in these tumors but they were less affected by HCB than the liver. (2) Tumors did not accumulate porphyrins al...
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todo:paper_03043835_v58_n3_p225_WainstokdeCalmanovici2023-10-03T15:20:06Z Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats Wainstok de Calmanovici, R. Cochón, A.C. Zenklusen, J.C. Aldonatti, C. Cabral, J.R.P. San Martín de Viale, L.C. diethylnitrosamine hepatocarcinoma hexachlorobenzene porphyria porphyrins diethylnitrosamine hexachlorobenzene animal model article controlled study liver tumor porphyria priority journal rat 5-Aminolevulinate Synthetase Aminolevulinic Acid Animal Carcinoma, Hepatocellular Cytochrome P-450 Enzyme System Diethylnitrosamine Female Ferrochelatase Hexachlorobenzene Liver Liver Neoplasms Porphobilinogen Porphyria Porphyrins Rats Support, Non-U.S. Gov't The response of female BDVI rats bearing diethylnitrosamine (DENA)-induced hepatic tumors to the porphyrinogenic action of hexachlorobenzene (HCB) was studied. (1) The heme pathway operates in these tumors but they were less affected by HCB than the liver. (2) Tumors did not accumulate porphyrins although the surrounding liver accumulated more porphyrins than livers treated with HCB. (3) DENA HCB livers which developed a well defined tumor showed slightly less porphyrinogen carboxylyase inhibition and δ-aminolaevulinate synthase induction than HCB rats. (4) The results of the present work suggest that endogenously formed porphyrins would be unable to be accumulated by DENA-induced tumors when the tumoral development precedes the onset of the porphyria. © 1991. Fil:Wainstok de Calmanovici, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cochón, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:San Martín de Viale, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03043835_v58_n3_p225_WainstokdeCalmanovici |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
diethylnitrosamine hepatocarcinoma hexachlorobenzene porphyria porphyrins diethylnitrosamine hexachlorobenzene animal model article controlled study liver tumor porphyria priority journal rat 5-Aminolevulinate Synthetase Aminolevulinic Acid Animal Carcinoma, Hepatocellular Cytochrome P-450 Enzyme System Diethylnitrosamine Female Ferrochelatase Hexachlorobenzene Liver Liver Neoplasms Porphobilinogen Porphyria Porphyrins Rats Support, Non-U.S. Gov't |
| spellingShingle |
diethylnitrosamine hepatocarcinoma hexachlorobenzene porphyria porphyrins diethylnitrosamine hexachlorobenzene animal model article controlled study liver tumor porphyria priority journal rat 5-Aminolevulinate Synthetase Aminolevulinic Acid Animal Carcinoma, Hepatocellular Cytochrome P-450 Enzyme System Diethylnitrosamine Female Ferrochelatase Hexachlorobenzene Liver Liver Neoplasms Porphobilinogen Porphyria Porphyrins Rats Support, Non-U.S. Gov't Wainstok de Calmanovici, R. Cochón, A.C. Zenklusen, J.C. Aldonatti, C. Cabral, J.R.P. San Martín de Viale, L.C. Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats |
| topic_facet |
diethylnitrosamine hepatocarcinoma hexachlorobenzene porphyria porphyrins diethylnitrosamine hexachlorobenzene animal model article controlled study liver tumor porphyria priority journal rat 5-Aminolevulinate Synthetase Aminolevulinic Acid Animal Carcinoma, Hepatocellular Cytochrome P-450 Enzyme System Diethylnitrosamine Female Ferrochelatase Hexachlorobenzene Liver Liver Neoplasms Porphobilinogen Porphyria Porphyrins Rats Support, Non-U.S. Gov't |
| description |
The response of female BDVI rats bearing diethylnitrosamine (DENA)-induced hepatic tumors to the porphyrinogenic action of hexachlorobenzene (HCB) was studied. (1) The heme pathway operates in these tumors but they were less affected by HCB than the liver. (2) Tumors did not accumulate porphyrins although the surrounding liver accumulated more porphyrins than livers treated with HCB. (3) DENA HCB livers which developed a well defined tumor showed slightly less porphyrinogen carboxylyase inhibition and δ-aminolaevulinate synthase induction than HCB rats. (4) The results of the present work suggest that endogenously formed porphyrins would be unable to be accumulated by DENA-induced tumors when the tumoral development precedes the onset of the porphyria. © 1991. |
| format |
JOUR |
| author |
Wainstok de Calmanovici, R. Cochón, A.C. Zenklusen, J.C. Aldonatti, C. Cabral, J.R.P. San Martín de Viale, L.C. |
| author_facet |
Wainstok de Calmanovici, R. Cochón, A.C. Zenklusen, J.C. Aldonatti, C. Cabral, J.R.P. San Martín de Viale, L.C. |
| author_sort |
Wainstok de Calmanovici, R. |
| title |
Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats |
| title_short |
Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats |
| title_full |
Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats |
| title_fullStr |
Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats |
| title_full_unstemmed |
Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats |
| title_sort |
influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats |
| url |
http://hdl.handle.net/20.500.12110/paper_03043835_v58_n3_p225_WainstokdeCalmanovici |
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