Tumor-specific MAGE proteins as regulators of p53 function

Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms cont...

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Autores principales: Ladelfa, M.F., Peche, L.Y., Toledo, M.F., Laiseca, J.E., Schneider, C., Monte, M.
Formato: JOUR
Materias:
Anticancer therapies
MAGE
P53
Transcriptional inhibition
etoposide
histone deacetylase inhibitor
melanoma antigen 1
protein Bax
protein p53
survivin
trichostatin A
carcinogenesis
cell proliferation
drug cytotoxicity
drug targeting
gene expression regulation
head and neck carcinoma
human
melanoma
multiple myeloma
nonhuman
priority journal
protein expression
protein family
protein function
sequence homology
short survey
Animals
Cell Growth Processes
Humans
Melanoma
Melanoma-Specific Antigens
Tumor Suppressor Protein p53
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03043835_v325_n1_p11_Ladelfa
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_03043835_v325_n1_p11_Ladelfa
record_format dspace
spelling todo:paper_03043835_v325_n1_p11_Ladelfa2023-10-03T15:20:05Z Tumor-specific MAGE proteins as regulators of p53 function Ladelfa, M.F. Peche, L.Y. Toledo, M.F. Laiseca, J.E. Schneider, C. Monte, M. Anticancer therapies MAGE P53 Transcriptional inhibition etoposide histone deacetylase inhibitor melanoma antigen 1 protein Bax protein p53 survivin trichostatin A carcinogenesis cell proliferation drug cytotoxicity drug targeting gene expression regulation head and neck carcinoma human melanoma multiple myeloma nonhuman priority journal protein expression protein family protein function sequence homology short survey Animals Cell Growth Processes Humans Melanoma Melanoma-Specific Antigens Tumor Suppressor Protein p53 Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions. © 2012 Elsevier Ireland Ltd. Fil:Ladelfa, M.F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Monte, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03043835_v325_n1_p11_Ladelfa
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Anticancer therapies
MAGE
P53
Transcriptional inhibition
etoposide
histone deacetylase inhibitor
melanoma antigen 1
protein Bax
protein p53
survivin
trichostatin A
carcinogenesis
cell proliferation
drug cytotoxicity
drug targeting
gene expression regulation
head and neck carcinoma
human
melanoma
multiple myeloma
nonhuman
priority journal
protein expression
protein family
protein function
sequence homology
short survey
Animals
Cell Growth Processes
Humans
Melanoma
Melanoma-Specific Antigens
Tumor Suppressor Protein p53
spellingShingle Anticancer therapies
MAGE
P53
Transcriptional inhibition
etoposide
histone deacetylase inhibitor
melanoma antigen 1
protein Bax
protein p53
survivin
trichostatin A
carcinogenesis
cell proliferation
drug cytotoxicity
drug targeting
gene expression regulation
head and neck carcinoma
human
melanoma
multiple myeloma
nonhuman
priority journal
protein expression
protein family
protein function
sequence homology
short survey
Animals
Cell Growth Processes
Humans
Melanoma
Melanoma-Specific Antigens
Tumor Suppressor Protein p53
Ladelfa, M.F.
Peche, L.Y.
Toledo, M.F.
Laiseca, J.E.
Schneider, C.
Monte, M.
Tumor-specific MAGE proteins as regulators of p53 function
topic_facet Anticancer therapies
MAGE
P53
Transcriptional inhibition
etoposide
histone deacetylase inhibitor
melanoma antigen 1
protein Bax
protein p53
survivin
trichostatin A
carcinogenesis
cell proliferation
drug cytotoxicity
drug targeting
gene expression regulation
head and neck carcinoma
human
melanoma
multiple myeloma
nonhuman
priority journal
protein expression
protein family
protein function
sequence homology
short survey
Animals
Cell Growth Processes
Humans
Melanoma
Melanoma-Specific Antigens
Tumor Suppressor Protein p53
description Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions. © 2012 Elsevier Ireland Ltd.
format JOUR
author Ladelfa, M.F.
Peche, L.Y.
Toledo, M.F.
Laiseca, J.E.
Schneider, C.
Monte, M.
author_facet Ladelfa, M.F.
Peche, L.Y.
Toledo, M.F.
Laiseca, J.E.
Schneider, C.
Monte, M.
author_sort Ladelfa, M.F.
title Tumor-specific MAGE proteins as regulators of p53 function
title_short Tumor-specific MAGE proteins as regulators of p53 function
title_full Tumor-specific MAGE proteins as regulators of p53 function
title_fullStr Tumor-specific MAGE proteins as regulators of p53 function
title_full_unstemmed Tumor-specific MAGE proteins as regulators of p53 function
title_sort tumor-specific mage proteins as regulators of p53 function
url http://hdl.handle.net/20.500.12110/paper_03043835_v325_n1_p11_Ladelfa
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AT toledomf tumorspecificmageproteinsasregulatorsofp53function
AT laisecaje tumorspecificmageproteinsasregulatorsofp53function
AT schneiderc tumorspecificmageproteinsasregulatorsofp53function
AT montem tumorspecificmageproteinsasregulatorsofp53function
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