Expression and methylation status of female-predominant GH-dependent liver genes are modified by neonatal androgenization in female mice

Neonatal androgenization masculinizes the GH axis and thus may impact on liver gene regulation. Neonatal testosterone administration to female mice decreased (defeminized) female predominant GH-dependent liver gene expression (Hnf6, Adh1, Prlr, Cyp3a41) and did not modify male predominant genes (Cyp...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ramirez, M.C., Zubeldía-Brenner, L., Wargon, V., Ornstein, A.M., Becu-Villalobos, D.
Formato: JOUR
Materias:
Cyps
DNA methylation
GH
Liver
Neonatal testosterone
Sexual differences
androgen
DNA
endocrine disruptor
growth hormone
messenger RNA
testosterone
animal experiment
animal tissue
article
Cyp7b1 gene
female
gene expression
Hnf6 gene
liver
male
mouse
newborn
nonhuman
nucleotide sequence
priority journal
promoter region
sex difference
sex differentiation
sexual development
signal transduction
Androgens
Animals
Animals, Newborn
DNA Methylation
Female
Gene Expression Regulation, Developmental
Growth Hormone
Hepatocyte Nuclear Factor 6
Male
Mice
Promoter Regions, Genetic
Sex Characteristics
Signal Transduction
Steroid Hydroxylases
Testosterone
Virilism
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03037207_v382_n2_p825_Ramirez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares