Genetically modified mouse models in studies of luteinising hormone action

Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-α(Cα), luteinising hormone (LH)...

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Autores principales: Huhtaniemi, I., Ahtiainen, P., Pakarainen, T., Rulli, S.B., Zhang, F.-P., Poutanen, M.
Formato: JOUR
Materias:
Choriongonadotrophin (hCG)
Knockout mice
LH receptor
Luteinising hormone (LH)
Pituitary-gonadal function
Reproduction
Sexual development
Transgenic mice
chorionic gonadotropin
luteinizing hormone
luteinizing hormone receptor
DNA modification
gene overexpression
hormone action
hypophysis function
knockout mouse
Leydig cell
maturation
nonhuman
oocyte
phenotype
priority journal
reproduction
reverse transcription polymerase chain reaction
review
sexual development
spermatogenesis
transgenic mouse
Animals
Animals, Genetically Modified
Female
Luteinizing Hormone
Male
Mice
Mice, Knockout
Mice, Transgenic
Ovary
Receptors, LH
Testis
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03037207_v252_n1-2_p126_Huhtaniemi
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_03037207_v252_n1-2_p126_Huhtaniemi2023-10-03T15:19:50Z Genetically modified mouse models in studies of luteinising hormone action Huhtaniemi, I. Ahtiainen, P. Pakarainen, T. Rulli, S.B. Zhang, F.-P. Poutanen, M. Choriongonadotrophin (hCG) Knockout mice LH receptor Luteinising hormone (LH) Pituitary-gonadal function Reproduction Sexual development Transgenic mice chorionic gonadotropin luteinizing hormone luteinizing hormone receptor DNA modification gene overexpression hormone action hypophysis function knockout mouse Leydig cell maturation nonhuman oocyte phenotype priority journal reproduction reverse transcription polymerase chain reaction review sexual development spermatogenesis transgenic mouse Animals Animals, Genetically Modified Female Luteinizing Hormone Male Mice Mice, Knockout Mice, Transgenic Ovary Receptors, LH Testis Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-α(Cα), luteinising hormone (LH) β and follicle-stimulating hormone (FSH) β subunits, and the two gonadotrophin receptors (R), LHR and FSHR. In addition, there are also transgenic (TG) mice overexpressing gonadotrophin subunits and producing supraphysiological levels of these hormones. These models have offered relevant phenocopies for similar mutations in humans and to a great extent expanded our knowledge on normal and pathological functions of the hypothalamic-pituitary-gonadal (HPG) axis. The purpose of this article is to review some of our recent findings on two such mouse models, the LHR KO mouse (LuRKO), and the hCG overexpressing TG mouse (hCG+). © 2006 Elsevier Ireland Ltd. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03037207_v252_n1-2_p126_Huhtaniemi
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Choriongonadotrophin (hCG)
Knockout mice
LH receptor
Luteinising hormone (LH)
Pituitary-gonadal function
Reproduction
Sexual development
Transgenic mice
chorionic gonadotropin
luteinizing hormone
luteinizing hormone receptor
DNA modification
gene overexpression
hormone action
hypophysis function
knockout mouse
Leydig cell
maturation
nonhuman
oocyte
phenotype
priority journal
reproduction
reverse transcription polymerase chain reaction
review
sexual development
spermatogenesis
transgenic mouse
Animals
Animals, Genetically Modified
Female
Luteinizing Hormone
Male
Mice
Mice, Knockout
Mice, Transgenic
Ovary
Receptors, LH
Testis
spellingShingle Choriongonadotrophin (hCG)
Knockout mice
LH receptor
Luteinising hormone (LH)
Pituitary-gonadal function
Reproduction
Sexual development
Transgenic mice
chorionic gonadotropin
luteinizing hormone
luteinizing hormone receptor
DNA modification
gene overexpression
hormone action
hypophysis function
knockout mouse
Leydig cell
maturation
nonhuman
oocyte
phenotype
priority journal
reproduction
reverse transcription polymerase chain reaction
review
sexual development
spermatogenesis
transgenic mouse
Animals
Animals, Genetically Modified
Female
Luteinizing Hormone
Male
Mice
Mice, Knockout
Mice, Transgenic
Ovary
Receptors, LH
Testis
Huhtaniemi, I.
Ahtiainen, P.
Pakarainen, T.
Rulli, S.B.
Zhang, F.-P.
Poutanen, M.
Genetically modified mouse models in studies of luteinising hormone action
topic_facet Choriongonadotrophin (hCG)
Knockout mice
LH receptor
Luteinising hormone (LH)
Pituitary-gonadal function
Reproduction
Sexual development
Transgenic mice
chorionic gonadotropin
luteinizing hormone
luteinizing hormone receptor
DNA modification
gene overexpression
hormone action
hypophysis function
knockout mouse
Leydig cell
maturation
nonhuman
oocyte
phenotype
priority journal
reproduction
reverse transcription polymerase chain reaction
review
sexual development
spermatogenesis
transgenic mouse
Animals
Animals, Genetically Modified
Female
Luteinizing Hormone
Male
Mice
Mice, Knockout
Mice, Transgenic
Ovary
Receptors, LH
Testis
description Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-α(Cα), luteinising hormone (LH) β and follicle-stimulating hormone (FSH) β subunits, and the two gonadotrophin receptors (R), LHR and FSHR. In addition, there are also transgenic (TG) mice overexpressing gonadotrophin subunits and producing supraphysiological levels of these hormones. These models have offered relevant phenocopies for similar mutations in humans and to a great extent expanded our knowledge on normal and pathological functions of the hypothalamic-pituitary-gonadal (HPG) axis. The purpose of this article is to review some of our recent findings on two such mouse models, the LHR KO mouse (LuRKO), and the hCG overexpressing TG mouse (hCG+). © 2006 Elsevier Ireland Ltd. All rights reserved.
format JOUR
author Huhtaniemi, I.
Ahtiainen, P.
Pakarainen, T.
Rulli, S.B.
Zhang, F.-P.
Poutanen, M.
author_facet Huhtaniemi, I.
Ahtiainen, P.
Pakarainen, T.
Rulli, S.B.
Zhang, F.-P.
Poutanen, M.
author_sort Huhtaniemi, I.
title Genetically modified mouse models in studies of luteinising hormone action
title_short Genetically modified mouse models in studies of luteinising hormone action
title_full Genetically modified mouse models in studies of luteinising hormone action
title_fullStr Genetically modified mouse models in studies of luteinising hormone action
title_full_unstemmed Genetically modified mouse models in studies of luteinising hormone action
title_sort genetically modified mouse models in studies of luteinising hormone action
url http://hdl.handle.net/20.500.12110/paper_03037207_v252_n1-2_p126_Huhtaniemi
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AT rullisb geneticallymodifiedmousemodelsinstudiesofluteinisinghormoneaction
AT zhangfp geneticallymodifiedmousemodelsinstudiesofluteinisinghormoneaction
AT poutanenm geneticallymodifiedmousemodelsinstudiesofluteinisinghormoneaction
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