Laminin inhibits lactotroph proliferation and is reduced in early prolactinoma development
Laminin is a component of the extracellular matrix (ECM) that regulates cell proliferation and hormone secretion. Here we describe the effects of laminin on prolactin secretion in normal and tumor cells and analyze laminin expression pattern during prolactinoma development. Prolactin secretion and c...
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todo:paper_03037207_v207_n1-2_p13_Kuchenbauer2023-10-03T15:19:47Z Laminin inhibits lactotroph proliferation and is reduced in early prolactinoma development Kuchenbauer, F. Theodoropoulou, M. Hopfner, U. Stalla, J. Renner, U. Tonn, J.C. Low, M.J. Arzt, E. Stalla, G.K. Páez-Pereda, M. Extracellular matrix Laminin Pituitary neoplasm Prolactin dopamine 2 receptor laminin prolactin animal cell animal model animal tissue article cell proliferation controlled study disease course drug effect hormone determination human human tissue hyperplasia hypophysis hypophysis cell male mouse nonhuman priority journal prolactin release prolactin secreting cell prolactin synthesis prolactinoma protein analysis protein deficiency protein determination protein expression protein function protein localization quantitative analysis rat tissue distribution tumor cell wild type Laminin is a component of the extracellular matrix (ECM) that regulates cell proliferation and hormone secretion. Here we describe the effects of laminin on prolactin secretion in normal and tumor cells and analyze laminin expression pattern during prolactinoma development. Prolactin secretion and cell proliferation were inhibited by laminin in GH3 cells. In contrast, no effect was observed in normal pituitary cells. Laminin showed a dynamic expression pattern during prolactinoma development, which was: (a) strong in normal pituitaries from wild type or dopamine D2 receptor deficient mice, (b) lower in pituitary hyperplasia and (c) markedly reduced in prolactinomas from D2R -/- mice. A similar gradual decrease in laminin was found by comparing normal human pituitaries, human pituitary hyperplasia and human prolactinomas. These results show dynamic changes of laminin expression during prolactinoma formation which, due to laminin action on PRL production and cell proliferation, indicate a possible role for laminin in prolactinoma development. © 2003 Elsevier Ireland Ltd. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03037207_v207_n1-2_p13_Kuchenbauer |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Extracellular matrix Laminin Pituitary neoplasm Prolactin dopamine 2 receptor laminin prolactin animal cell animal model animal tissue article cell proliferation controlled study disease course drug effect hormone determination human human tissue hyperplasia hypophysis hypophysis cell male mouse nonhuman priority journal prolactin release prolactin secreting cell prolactin synthesis prolactinoma protein analysis protein deficiency protein determination protein expression protein function protein localization quantitative analysis rat tissue distribution tumor cell wild type |
| spellingShingle |
Extracellular matrix Laminin Pituitary neoplasm Prolactin dopamine 2 receptor laminin prolactin animal cell animal model animal tissue article cell proliferation controlled study disease course drug effect hormone determination human human tissue hyperplasia hypophysis hypophysis cell male mouse nonhuman priority journal prolactin release prolactin secreting cell prolactin synthesis prolactinoma protein analysis protein deficiency protein determination protein expression protein function protein localization quantitative analysis rat tissue distribution tumor cell wild type Kuchenbauer, F. Theodoropoulou, M. Hopfner, U. Stalla, J. Renner, U. Tonn, J.C. Low, M.J. Arzt, E. Stalla, G.K. Páez-Pereda, M. Laminin inhibits lactotroph proliferation and is reduced in early prolactinoma development |
| topic_facet |
Extracellular matrix Laminin Pituitary neoplasm Prolactin dopamine 2 receptor laminin prolactin animal cell animal model animal tissue article cell proliferation controlled study disease course drug effect hormone determination human human tissue hyperplasia hypophysis hypophysis cell male mouse nonhuman priority journal prolactin release prolactin secreting cell prolactin synthesis prolactinoma protein analysis protein deficiency protein determination protein expression protein function protein localization quantitative analysis rat tissue distribution tumor cell wild type |
| description |
Laminin is a component of the extracellular matrix (ECM) that regulates cell proliferation and hormone secretion. Here we describe the effects of laminin on prolactin secretion in normal and tumor cells and analyze laminin expression pattern during prolactinoma development. Prolactin secretion and cell proliferation were inhibited by laminin in GH3 cells. In contrast, no effect was observed in normal pituitary cells. Laminin showed a dynamic expression pattern during prolactinoma development, which was: (a) strong in normal pituitaries from wild type or dopamine D2 receptor deficient mice, (b) lower in pituitary hyperplasia and (c) markedly reduced in prolactinomas from D2R -/- mice. A similar gradual decrease in laminin was found by comparing normal human pituitaries, human pituitary hyperplasia and human prolactinomas. These results show dynamic changes of laminin expression during prolactinoma formation which, due to laminin action on PRL production and cell proliferation, indicate a possible role for laminin in prolactinoma development. © 2003 Elsevier Ireland Ltd. All rights reserved. |
| format |
JOUR |
| author |
Kuchenbauer, F. Theodoropoulou, M. Hopfner, U. Stalla, J. Renner, U. Tonn, J.C. Low, M.J. Arzt, E. Stalla, G.K. Páez-Pereda, M. |
| author_facet |
Kuchenbauer, F. Theodoropoulou, M. Hopfner, U. Stalla, J. Renner, U. Tonn, J.C. Low, M.J. Arzt, E. Stalla, G.K. Páez-Pereda, M. |
| author_sort |
Kuchenbauer, F. |
| title |
Laminin inhibits lactotroph proliferation and is reduced in early prolactinoma development |
| title_short |
Laminin inhibits lactotroph proliferation and is reduced in early prolactinoma development |
| title_full |
Laminin inhibits lactotroph proliferation and is reduced in early prolactinoma development |
| title_fullStr |
Laminin inhibits lactotroph proliferation and is reduced in early prolactinoma development |
| title_full_unstemmed |
Laminin inhibits lactotroph proliferation and is reduced in early prolactinoma development |
| title_sort |
laminin inhibits lactotroph proliferation and is reduced in early prolactinoma development |
| url |
http://hdl.handle.net/20.500.12110/paper_03037207_v207_n1-2_p13_Kuchenbauer |
| work_keys_str_mv |
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| _version_ |
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