New aspects in the diagnosis and treatment of cushing disease

Cushing disease which is caused by the excessive production of ACTH is a rare and complex endocrine disorder that still represents a major challenge for the physician in terms of accurate diagnosis and efficient treatment. Diagnosing Cushing syndrome and its etiology is an elaborate procedure and no...

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Autores principales:	Labeur, M., Theodoropoulou, M., Sievers, C., Paez-Pereda, M., Castillo, V., Arzt, E., Stalla, G.K.
Formato:	SER
Materias:	dopamine receptor stimulating agent drug derivative ligand peroxisome proliferator activated receptor gamma retinoic acid somatostatin algorithm animal conference paper Cushing disease differential diagnosis human Algorithms Animals Diagnosis, Differential Dopamine Agonists Humans Ligands Pituitary ACTH Hypersecretion PPAR gamma Somatostatin Tretinoin
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03013073_v35_n_p169_Labeur
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_03013073_v35_n_p169_Labeur
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spelling	todo:paper_03013073_v35_n_p169_Labeur2023-10-03T15:18:18Z New aspects in the diagnosis and treatment of cushing disease Labeur, M. Theodoropoulou, M. Sievers, C. Paez-Pereda, M. Castillo, V. Arzt, E. Stalla, G.K. dopamine receptor stimulating agent drug derivative ligand peroxisome proliferator activated receptor gamma retinoic acid somatostatin algorithm animal conference paper Cushing disease differential diagnosis human Algorithms Animals Diagnosis, Differential Dopamine Agonists Humans Ligands Pituitary ACTH Hypersecretion PPAR gamma Somatostatin Tretinoin Cushing disease which is caused by the excessive production of ACTH is a rare and complex endocrine disorder that still represents a major challenge for the physician in terms of accurate diagnosis and efficient treatment. Diagnosing Cushing syndrome and its etiology is an elaborate procedure and no single test is sensitive and specific enough to provide sufficient accuracy. Therefore, an ordered cascade of tests is necessary recommended by a consensus statement in 2002. The proposed diagnostic algorithm will be summarized in the following section. In the absence of efficient drug therapy, transsphenoidal resection of the pituitary adenoma is the treatment of choice for the reduction of ACTH secretion. However, not all patients can be cured by surgery. In the present article, we examine recent studies that have investigated the therapeutic potential of new generations of drugs for the treatment of Cushing disease such as cabergoline and SOM230. The role of nuclear receptors: retinoic acid receptors and peroxisome proliferator-activated receptor-γ as new approaches for treating pituitary tumors is also discussed. Copyright © 2006 S. Karger AG. Fil:Labeur, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Paez-Pereda, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. SER info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03013073_v35_n_p169_Labeur
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	dopamine receptor stimulating agent drug derivative ligand peroxisome proliferator activated receptor gamma retinoic acid somatostatin algorithm animal conference paper Cushing disease differential diagnosis human Algorithms Animals Diagnosis, Differential Dopamine Agonists Humans Ligands Pituitary ACTH Hypersecretion PPAR gamma Somatostatin Tretinoin
spellingShingle	dopamine receptor stimulating agent drug derivative ligand peroxisome proliferator activated receptor gamma retinoic acid somatostatin algorithm animal conference paper Cushing disease differential diagnosis human Algorithms Animals Diagnosis, Differential Dopamine Agonists Humans Ligands Pituitary ACTH Hypersecretion PPAR gamma Somatostatin Tretinoin Labeur, M. Theodoropoulou, M. Sievers, C. Paez-Pereda, M. Castillo, V. Arzt, E. Stalla, G.K. New aspects in the diagnosis and treatment of cushing disease
topic_facet	dopamine receptor stimulating agent drug derivative ligand peroxisome proliferator activated receptor gamma retinoic acid somatostatin algorithm animal conference paper Cushing disease differential diagnosis human Algorithms Animals Diagnosis, Differential Dopamine Agonists Humans Ligands Pituitary ACTH Hypersecretion PPAR gamma Somatostatin Tretinoin
description	Cushing disease which is caused by the excessive production of ACTH is a rare and complex endocrine disorder that still represents a major challenge for the physician in terms of accurate diagnosis and efficient treatment. Diagnosing Cushing syndrome and its etiology is an elaborate procedure and no single test is sensitive and specific enough to provide sufficient accuracy. Therefore, an ordered cascade of tests is necessary recommended by a consensus statement in 2002. The proposed diagnostic algorithm will be summarized in the following section. In the absence of efficient drug therapy, transsphenoidal resection of the pituitary adenoma is the treatment of choice for the reduction of ACTH secretion. However, not all patients can be cured by surgery. In the present article, we examine recent studies that have investigated the therapeutic potential of new generations of drugs for the treatment of Cushing disease such as cabergoline and SOM230. The role of nuclear receptors: retinoic acid receptors and peroxisome proliferator-activated receptor-γ as new approaches for treating pituitary tumors is also discussed. Copyright © 2006 S. Karger AG.
format	SER
author	Labeur, M. Theodoropoulou, M. Sievers, C. Paez-Pereda, M. Castillo, V. Arzt, E. Stalla, G.K.
author_facet	Labeur, M. Theodoropoulou, M. Sievers, C. Paez-Pereda, M. Castillo, V. Arzt, E. Stalla, G.K.
author_sort	Labeur, M.
title	New aspects in the diagnosis and treatment of cushing disease
title_short	New aspects in the diagnosis and treatment of cushing disease
title_full	New aspects in the diagnosis and treatment of cushing disease
title_fullStr	New aspects in the diagnosis and treatment of cushing disease
title_full_unstemmed	New aspects in the diagnosis and treatment of cushing disease
title_sort	new aspects in the diagnosis and treatment of cushing disease
url	http://hdl.handle.net/20.500.12110/paper_03013073_v35_n_p169_Labeur
work_keys_str_mv	AT labeurm newaspectsinthediagnosisandtreatmentofcushingdisease AT theodoropouloum newaspectsinthediagnosisandtreatmentofcushingdisease AT sieversc newaspectsinthediagnosisandtreatmentofcushingdisease AT paezperedam newaspectsinthediagnosisandtreatmentofcushingdisease AT castillov newaspectsinthediagnosisandtreatmentofcushingdisease AT arzte newaspectsinthediagnosisandtreatmentofcushingdisease AT stallagk newaspectsinthediagnosisandtreatmentofcushingdisease
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New aspects in the diagnosis and treatment of cushing disease

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