Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats

The effect of the opiate antagonist naloxone on serum prolactin after treatment with serotonin, arginine vasotocin (AVT) or melatonin was studied in prepubertal and adult unanesthetized rats. Prolactin was quantified in blood samples withdrawn through an intrajugular silastic cannula from undisturbe...

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Autores principales:	Somoza, G.M., Larrea, G.A., Becú, D., Cardinali, D.P., Libertun, C.
Formato:	JOUR
Materias:	naloxone Prolactin serotonin argiprestocin melatonin opiate receptor animal experiment drug efficacy endocrine system hypophysis nonhuman prolactin blood level radioimmunoassay rat Animals Female Melatonin Movement Naloxone Rats Serotonin Vasotocin
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03009564_v56_n1_p97_Somoza
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_03009564_v56_n1_p97_Somoza
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spelling	todo:paper_03009564_v56_n1_p97_Somoza2023-10-03T15:18:04Z Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats Somoza, G.M. Larrea, G.A. Becú, D. Cardinali, D.P. Libertun, C. naloxone Prolactin serotonin argiprestocin melatonin naloxone opiate receptor serotonin animal experiment drug efficacy endocrine system hypophysis nonhuman prolactin blood level radioimmunoassay rat Animals Female Melatonin Movement Naloxone Prolactin Rats Serotonin Vasotocin The effect of the opiate antagonist naloxone on serum prolactin after treatment with serotonin, arginine vasotocin (AVT) or melatonin was studied in prepubertal and adult unanesthetized rats. Prolactin was quantified in blood samples withdrawn through an intrajugular silastic cannula from undisturbed ovariectomized adult rats. After taking a basal sample, animals were injected through the cannula with naloxone (0.8 mg/kg) and 5 min later with serotonin creatinine sulphate (6.4 mg/kg), AVT (20 μg/kg), melatonin (4 mg/kg) or saline; new samples were taken 15 and 30 min thereafter. Injection of serotonin was followed by a 10-fold increase of prolactin levels 15 min later; this increase was drastically reduced, although not abolished, by pretreatment with naloxone. In animals injected with saline, AVT or melatonin, no significant changes in serum prolactin were observed. In a second group of experiments, 30 day-old female rats injected with serotonin creatinine sulphate (10 mg/kg, i.p.) exhibited a 6-fold increase in serum prolactin 15 min after injection; this increment was reduced but not abolished by pretreatment with naloxone (5 mg/kg, i.p.). It is postulated that the prolactin releasing effect of serotonin is mediated, at least in part, by an opioid receptor. © 1983 Springer-Verlag. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03009564_v56_n1_p97_Somoza
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	naloxone Prolactin serotonin argiprestocin melatonin naloxone opiate receptor serotonin animal experiment drug efficacy endocrine system hypophysis nonhuman prolactin blood level radioimmunoassay rat Animals Female Melatonin Movement Naloxone Prolactin Rats Serotonin Vasotocin
spellingShingle	naloxone Prolactin serotonin argiprestocin melatonin naloxone opiate receptor serotonin animal experiment drug efficacy endocrine system hypophysis nonhuman prolactin blood level radioimmunoassay rat Animals Female Melatonin Movement Naloxone Prolactin Rats Serotonin Vasotocin Somoza, G.M. Larrea, G.A. Becú, D. Cardinali, D.P. Libertun, C. Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats
topic_facet	naloxone Prolactin serotonin argiprestocin melatonin naloxone opiate receptor serotonin animal experiment drug efficacy endocrine system hypophysis nonhuman prolactin blood level radioimmunoassay rat Animals Female Melatonin Movement Naloxone Prolactin Rats Serotonin Vasotocin
description	The effect of the opiate antagonist naloxone on serum prolactin after treatment with serotonin, arginine vasotocin (AVT) or melatonin was studied in prepubertal and adult unanesthetized rats. Prolactin was quantified in blood samples withdrawn through an intrajugular silastic cannula from undisturbed ovariectomized adult rats. After taking a basal sample, animals were injected through the cannula with naloxone (0.8 mg/kg) and 5 min later with serotonin creatinine sulphate (6.4 mg/kg), AVT (20 μg/kg), melatonin (4 mg/kg) or saline; new samples were taken 15 and 30 min thereafter. Injection of serotonin was followed by a 10-fold increase of prolactin levels 15 min later; this increase was drastically reduced, although not abolished, by pretreatment with naloxone. In animals injected with saline, AVT or melatonin, no significant changes in serum prolactin were observed. In a second group of experiments, 30 day-old female rats injected with serotonin creatinine sulphate (10 mg/kg, i.p.) exhibited a 6-fold increase in serum prolactin 15 min after injection; this increment was reduced but not abolished by pretreatment with naloxone (5 mg/kg, i.p.). It is postulated that the prolactin releasing effect of serotonin is mediated, at least in part, by an opioid receptor. © 1983 Springer-Verlag.
format	JOUR
author	Somoza, G.M. Larrea, G.A. Becú, D. Cardinali, D.P. Libertun, C.
author_facet	Somoza, G.M. Larrea, G.A. Becú, D. Cardinali, D.P. Libertun, C.
author_sort	Somoza, G.M.
title	Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats
title_short	Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats
title_full	Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats
title_fullStr	Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats
title_full_unstemmed	Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats
title_sort	inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats
url	http://hdl.handle.net/20.500.12110/paper_03009564_v56_n1_p97_Somoza
work_keys_str_mv	AT somozagm inhibitionbynaloxoneoftheserotonininducedprolactinreleaseinfreemovingrats AT larreaga inhibitionbynaloxoneoftheserotonininducedprolactinreleaseinfreemovingrats AT becud inhibitionbynaloxoneoftheserotonininducedprolactinreleaseinfreemovingrats AT cardinalidp inhibitionbynaloxoneoftheserotonininducedprolactinreleaseinfreemovingrats AT libertunc inhibitionbynaloxoneoftheserotonininducedprolactinreleaseinfreemovingrats
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Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats

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