Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: A putative diagnostic role in resistant ovary syndrome?

OBJECTIVE: To evaluate the presence of circulating immunoglobulins that inhibit FSH binding to its receptor (Ig-FSHR) in patients with premature ovarian failure (POF). DESIGN Non-randomized study. Blood sampling for determination of circulating immunoglobulins. PATIENTS: Two hundred and forty-seven...

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Autores principales:	Chiauzzi, V.A., Bussmann, L., Calvo, J.C., Sundblad, V., Charreau, E.H.
Formato:	JOUR
Materias:	follitropin follitropin receptor immunoglobulin G adolescent adult animal tissue article binding affinity binding assay controlled study diagnostic accuracy diagnostic error diagnostic test diagnostic value female follitropin blood level hormone binding human immunoglobulin blood level major clinical study nonhuman premature ovarian failure priority journal rat resistant ovary syndrome Adolescent Adult Biological Markers Case-Control Studies Female Follicle Stimulating Hormone Humans Immunoglobulins Middle Aged Ovarian Failure, Premature Predictive Value of Tests Receptors, FSH
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03000664_v61_n1_p46_Chiauzzi
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_03000664_v61_n1_p46_Chiauzzi
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spelling	todo:paper_03000664_v61_n1_p46_Chiauzzi2023-10-03T15:17:31Z Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: A putative diagnostic role in resistant ovary syndrome? Chiauzzi, V.A. Bussmann, L. Calvo, J.C. Sundblad, V. Charreau, E.H. follitropin follitropin receptor immunoglobulin G adolescent adult animal tissue article binding affinity binding assay controlled study diagnostic accuracy diagnostic error diagnostic test diagnostic value female follitropin blood level hormone binding human immunoglobulin blood level major clinical study nonhuman premature ovarian failure priority journal rat resistant ovary syndrome Adolescent Adult Biological Markers Case-Control Studies Female Follicle Stimulating Hormone Humans Immunoglobulins Middle Aged Ovarian Failure, Premature Predictive Value of Tests Receptors, FSH OBJECTIVE: To evaluate the presence of circulating immunoglobulins that inhibit FSH binding to its receptor (Ig-FSHR) in patients with premature ovarian failure (POF). DESIGN Non-randomized study. Blood sampling for determination of circulating immunoglobulins. PATIENTS: Two hundred and forty-seven patients with POF and 60 normally menstruating women (controls). MEASUREMENTS: Circulating immunoglobulins that inhibit FSH binding to its receptor were assessed by FSH-binding inhibition assay. RESULTS: Twenty-three out of 247 women with POF presented circulating immunoglobulins that inhibit FSH binding to its receptor. These patients had been previously diagnosed as ROS. Sixty control subjects proved negative. CONCLUSION: Determination of the presence of circulating immunoglobulins that inhibit FSH binding to its receptor could be instrumental in diagnosing the gonadotropin resistance ovary syndrome. Fil:Calvo, J.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sundblad, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Charreau, E.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_03000664_v61_n1_p46_Chiauzzi
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	follitropin follitropin receptor immunoglobulin G adolescent adult animal tissue article binding affinity binding assay controlled study diagnostic accuracy diagnostic error diagnostic test diagnostic value female follitropin blood level hormone binding human immunoglobulin blood level major clinical study nonhuman premature ovarian failure priority journal rat resistant ovary syndrome Adolescent Adult Biological Markers Case-Control Studies Female Follicle Stimulating Hormone Humans Immunoglobulins Middle Aged Ovarian Failure, Premature Predictive Value of Tests Receptors, FSH
spellingShingle	follitropin follitropin receptor immunoglobulin G adolescent adult animal tissue article binding affinity binding assay controlled study diagnostic accuracy diagnostic error diagnostic test diagnostic value female follitropin blood level hormone binding human immunoglobulin blood level major clinical study nonhuman premature ovarian failure priority journal rat resistant ovary syndrome Adolescent Adult Biological Markers Case-Control Studies Female Follicle Stimulating Hormone Humans Immunoglobulins Middle Aged Ovarian Failure, Premature Predictive Value of Tests Receptors, FSH Chiauzzi, V.A. Bussmann, L. Calvo, J.C. Sundblad, V. Charreau, E.H. Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: A putative diagnostic role in resistant ovary syndrome?
topic_facet	follitropin follitropin receptor immunoglobulin G adolescent adult animal tissue article binding affinity binding assay controlled study diagnostic accuracy diagnostic error diagnostic test diagnostic value female follitropin blood level hormone binding human immunoglobulin blood level major clinical study nonhuman premature ovarian failure priority journal rat resistant ovary syndrome Adolescent Adult Biological Markers Case-Control Studies Female Follicle Stimulating Hormone Humans Immunoglobulins Middle Aged Ovarian Failure, Premature Predictive Value of Tests Receptors, FSH
description	OBJECTIVE: To evaluate the presence of circulating immunoglobulins that inhibit FSH binding to its receptor (Ig-FSHR) in patients with premature ovarian failure (POF). DESIGN Non-randomized study. Blood sampling for determination of circulating immunoglobulins. PATIENTS: Two hundred and forty-seven patients with POF and 60 normally menstruating women (controls). MEASUREMENTS: Circulating immunoglobulins that inhibit FSH binding to its receptor were assessed by FSH-binding inhibition assay. RESULTS: Twenty-three out of 247 women with POF presented circulating immunoglobulins that inhibit FSH binding to its receptor. These patients had been previously diagnosed as ROS. Sixty control subjects proved negative. CONCLUSION: Determination of the presence of circulating immunoglobulins that inhibit FSH binding to its receptor could be instrumental in diagnosing the gonadotropin resistance ovary syndrome.
format	JOUR
author	Chiauzzi, V.A. Bussmann, L. Calvo, J.C. Sundblad, V. Charreau, E.H.
author_facet	Chiauzzi, V.A. Bussmann, L. Calvo, J.C. Sundblad, V. Charreau, E.H.
author_sort	Chiauzzi, V.A.
title	Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: A putative diagnostic role in resistant ovary syndrome?
title_short	Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: A putative diagnostic role in resistant ovary syndrome?
title_full	Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: A putative diagnostic role in resistant ovary syndrome?
title_fullStr	Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: A putative diagnostic role in resistant ovary syndrome?
title_full_unstemmed	Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: A putative diagnostic role in resistant ovary syndrome?
title_sort	circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: a putative diagnostic role in resistant ovary syndrome?
url	http://hdl.handle.net/20.500.12110/paper_03000664_v61_n1_p46_Chiauzzi
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Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: A putative diagnostic role in resistant ovary syndrome?

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