Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat

1. After reaching its final destination the GnRH neuronal network develops under the influence of both excitatory and inhibitory inputs. 2. In the first 2 weeks of life, the immaturity of the GnRH neuronal system is reflected in sporadic unsynchronized bursts of the decapeptide, which determine the...

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Detalles Bibliográficos
Autores principales: Becú-Villalobos, D., Libertun, C.
Formato: JOUR
Materias:
gonadotropin-releasing hormone
growth factors
neurotransmitters
ontogeny
rat
gonadorelin
animal experiment
dopaminergic system
female
gonadorelin release
hormonal regulation
nerve cell network
neurotransmission
nonhuman
priority journal
puberty
review
Aging
Animal
Catecholamines
Dopamine
Endorphins
Excitatory Amino Acids
Female
Follicle Stimulating Hormone
Gonadorelin
Homeostasis
Hypothalamo-Hypophyseal System
Luteinizing Hormone
Neurons
Neuropeptides
Norepinephrine
Rats
Serotonin
Support, Non-U.S. Gov't
Synapses
Animalia
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02724340_v15_n1_p165_BecuVillalobos
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_02724340_v15_n1_p165_BecuVillalobos
record_format dspace
spelling todo:paper_02724340_v15_n1_p165_BecuVillalobos2023-10-03T15:14:57Z Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat Becú-Villalobos, D. Libertun, C. gonadotropin-releasing hormone growth factors neurotransmitters ontogeny rat gonadorelin animal experiment dopaminergic system female gonadorelin release hormonal regulation nerve cell network neurotransmission nonhuman priority journal puberty rat review Aging Animal Catecholamines Dopamine Endorphins Excitatory Amino Acids Female Follicle Stimulating Hormone Gonadorelin Homeostasis Hypothalamo-Hypophyseal System Luteinizing Hormone Neurons Neuropeptides Norepinephrine Rats Serotonin Support, Non-U.S. Gov't Synapses Animalia 1. After reaching its final destination the GnRH neuronal network develops under the influence of both excitatory and inhibitory inputs. 2. In the first 2 weeks of life, the immaturity of the GnRH neuronal system is reflected in sporadic unsynchronized bursts of the decapeptide, which determine the pattern of serum gonadotropin levels observed in female rats: high FSH levels and transient bursts of LH. The main inhibitory neuronal systems that operate in this period are the opioid and dopaminergic systems. A decrease in their inhibitory effectiveness may not be sufficient correctly to activate and synchronize the GnRH neuronal system. 3. There is a concomitant increase in excitatory inputs, mainly noradrenaline, excitatory amino acids, and NPY, which increase the synthesis and release of GnRH at the beginning of the juvenile period and participate in the coupling of GnRH neural activity to the ongoing rhythmic activity of a hypothalamic circadian oscillator. 4. The morphological changes of GnRH neurons which take place during the third and fourth weeks of life, and which are probably related to increasing estradiol levels, reflects the increasing complexity of the GnRH neuronal network, which establishes synaptic contacts to enable the expression of pulsatility and of the positive feedback of estradiol, both necessary components for the occurrence of puberty. © 1995 Plenum Publishing Corporation. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_02724340_v15_n1_p165_BecuVillalobos
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic gonadotropin-releasing hormone
growth factors
neurotransmitters
ontogeny
rat
gonadorelin
animal experiment
dopaminergic system
female
gonadorelin release
hormonal regulation
nerve cell network
neurotransmission
nonhuman
priority journal
puberty
rat
review
Aging
Animal
Catecholamines
Dopamine
Endorphins
Excitatory Amino Acids
Female
Follicle Stimulating Hormone
Gonadorelin
Homeostasis
Hypothalamo-Hypophyseal System
Luteinizing Hormone
Neurons
Neuropeptides
Norepinephrine
Rats
Serotonin
Support, Non-U.S. Gov't
Synapses
Animalia
spellingShingle gonadotropin-releasing hormone
growth factors
neurotransmitters
ontogeny
rat
gonadorelin
animal experiment
dopaminergic system
female
gonadorelin release
hormonal regulation
nerve cell network
neurotransmission
nonhuman
priority journal
puberty
rat
review
Aging
Animal
Catecholamines
Dopamine
Endorphins
Excitatory Amino Acids
Female
Follicle Stimulating Hormone
Gonadorelin
Homeostasis
Hypothalamo-Hypophyseal System
Luteinizing Hormone
Neurons
Neuropeptides
Norepinephrine
Rats
Serotonin
Support, Non-U.S. Gov't
Synapses
Animalia
Becú-Villalobos, D.
Libertun, C.
Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat
topic_facet gonadotropin-releasing hormone
growth factors
neurotransmitters
ontogeny
rat
gonadorelin
animal experiment
dopaminergic system
female
gonadorelin release
hormonal regulation
nerve cell network
neurotransmission
nonhuman
priority journal
puberty
rat
review
Aging
Animal
Catecholamines
Dopamine
Endorphins
Excitatory Amino Acids
Female
Follicle Stimulating Hormone
Gonadorelin
Homeostasis
Hypothalamo-Hypophyseal System
Luteinizing Hormone
Neurons
Neuropeptides
Norepinephrine
Rats
Serotonin
Support, Non-U.S. Gov't
Synapses
Animalia
description 1. After reaching its final destination the GnRH neuronal network develops under the influence of both excitatory and inhibitory inputs. 2. In the first 2 weeks of life, the immaturity of the GnRH neuronal system is reflected in sporadic unsynchronized bursts of the decapeptide, which determine the pattern of serum gonadotropin levels observed in female rats: high FSH levels and transient bursts of LH. The main inhibitory neuronal systems that operate in this period are the opioid and dopaminergic systems. A decrease in their inhibitory effectiveness may not be sufficient correctly to activate and synchronize the GnRH neuronal system. 3. There is a concomitant increase in excitatory inputs, mainly noradrenaline, excitatory amino acids, and NPY, which increase the synthesis and release of GnRH at the beginning of the juvenile period and participate in the coupling of GnRH neural activity to the ongoing rhythmic activity of a hypothalamic circadian oscillator. 4. The morphological changes of GnRH neurons which take place during the third and fourth weeks of life, and which are probably related to increasing estradiol levels, reflects the increasing complexity of the GnRH neuronal network, which establishes synaptic contacts to enable the expression of pulsatility and of the positive feedback of estradiol, both necessary components for the occurrence of puberty. © 1995 Plenum Publishing Corporation.
format JOUR
author Becú-Villalobos, D.
Libertun, C.
author_facet Becú-Villalobos, D.
Libertun, C.
author_sort Becú-Villalobos, D.
title Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat
title_short Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat
title_full Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat
title_fullStr Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat
title_full_unstemmed Development of gonadotropin-releasing hormone (GnRH) neuron regulation in the female rat
title_sort development of gonadotropin-releasing hormone (gnrh) neuron regulation in the female rat
url http://hdl.handle.net/20.500.12110/paper_02724340_v15_n1_p165_BecuVillalobos
work_keys_str_mv AT becuvillalobosd developmentofgonadotropinreleasinghormonegnrhneuronregulationinthefemalerat
AT libertunc developmentofgonadotropinreleasinghormonegnrhneuronregulationinthefemalerat
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