A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells

Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell. It has been proposed that calcium-induced calcium release (CIC...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Lioudyno, M., Hiel, H., Kong, J.-H., Katz, E., Waldman, E., Parameshwaran-Iyer, S., Glowatzki, E., Fuchs, P.A.
Formato: JOUR
Materias:
Acetylcholine
Calcium
Cochlea
Hair cell
Inhibition
Nicotinic
acetylcholine
ryanodine receptor
ryanodine receptor 1
unclassified drug
amplitude modulation
animal experiment
article
cochlea
controlled study
hair cell
nonhuman
priority journal
protein expression
rat
sarcoplasmic reticulum
synaptic membrane
Animals
Electrophysiology
Endoplasmic Reticulum
Evoked Potentials
Hair Cells
Neural Inhibition
Patch-Clamp Techniques
Potassium
Rats
Rats, Sprague-Dawley
Receptors, Nicotinic
Ryanodine Receptor Calcium Release Channel
Synapses
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02706474_v24_n49_p11160_Lioudyno
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell. It has been proposed that calcium-induced calcium release (CICR) from a near-membrane postsynaptic store supplements this process. Here, we demonstrate expression of type I ryanodine receptors in outer hair cells in the apical turn of the rat cochlea. Consistent with this finding, ryanodine and other store-active compounds alter the amplitude of transient currents produced by synaptic release of ACh, as well as the response of the hair cell to exogenous ACh. Like the sarcoplasmic reticulum of muscle, the "synaptoplasmic" cistern of the hair cell efficiently couples synaptic input to CICR.

Ejemplares similares