Repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice

Primary Objective: Repeated traumatic brain injuries (rmTBI) are frequently associated with debilitating neuropsychiatric conditions such as cognitive impairment, mood disorders, and post-traumatic stress disorder. We tested the hypothesis that repeated mild traumatic brain injury impairs spatial me...

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Autores principales:	Broussard, J.I., Acion, L., De Jesús-Cortés, H., Yin, T., Britt, J.K., Salas, R., Costa-Mattioli, M., Robertson, C., Pieper, A.A., Arciniegas, D.B., Jorge, R.
Formato:	JOUR
Materias:	Animal model anxiety chronic traumatic encephalopathy mild traumatic brain injury spatial memory glial fibrillary acidic protein animal cell animal experiment animal model animal tissue Article astrocytosis behavior cell activation controlled study corpus callosum dentate gyrus hippocampus immunohistochemistry locomotion male microglia motor performance mouse nervous system inflammation nonhuman open field test time spent in open arms traumatic brain injury animal animal behavior astrocyte brain brain concussion complication encephalitis gliosis maze test memory disorder motor activity pathology physiology psychology recurrent disease Animals Anxiety Astrocytes Behavior, Animal Brain Brain Concussion Encephalitis Gliosis Male Maze Learning Memory Disorders Mice Microglia Models, Animal Motor Activity Recurrence Spatial Memory
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_02699052_v32_n1_p113_Broussard
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_02699052_v32_n1_p113_Broussard2023-10-03T15:14:23Z Repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice Broussard, J.I. Acion, L. De Jesús-Cortés, H. Yin, T. Britt, J.K. Salas, R. Costa-Mattioli, M. Robertson, C. Pieper, A.A. Arciniegas, D.B. Jorge, R. Animal model anxiety chronic traumatic encephalopathy mild traumatic brain injury spatial memory glial fibrillary acidic protein animal cell animal experiment animal model animal tissue anxiety Article astrocytosis behavior cell activation controlled study corpus callosum dentate gyrus hippocampus immunohistochemistry locomotion male microglia motor performance mouse nervous system inflammation nonhuman open field test spatial memory time spent in open arms traumatic brain injury animal animal behavior anxiety astrocyte brain brain concussion complication encephalitis gliosis maze test memory disorder motor activity pathology physiology psychology recurrent disease spatial memory Animals Anxiety Astrocytes Behavior, Animal Brain Brain Concussion Encephalitis Gliosis Male Maze Learning Memory Disorders Mice Microglia Models, Animal Motor Activity Recurrence Spatial Memory Primary Objective: Repeated traumatic brain injuries (rmTBI) are frequently associated with debilitating neuropsychiatric conditions such as cognitive impairment, mood disorders, and post-traumatic stress disorder. We tested the hypothesis that repeated mild traumatic brain injury impairs spatial memory and enhances anxiety-like behaviour. Research Design: We used a between groups design using single (smTBI) or repeated (rmTBI) controlled cranial closed skull impacts to mice, compared to a control group. Methods and Procedures: We assessed the effects of smTBI and rmTBI using measures of motor performance (Rotarod Test [RT]), anxiety-like behaviour (Elevated Plus Maze [EPM] and Open Field [OF] tests), and spatial memory (Morris Water Maze [MWM]) within 12 days of the final injury. In separate groups of mice, astrocytosis and microglial activation were assessed 24 hours after the final injury using GFAP and IBA-1 immunohistochemistry. Main Outcomes and Results: RmTBI impaired spatial memory in the MWM and increased anxiety-like behaviour in the EPM and OFT. In addition, rmTBI elevated GFAP and IBA-1 immunohistochemistry throughout the mouse brain. RmTBI produced astrocytosis and microglial activation, and elicited impaired spatial memory and anxiety-like behaviour. Conclusions: rmTBI produces acute cognitive and anxiety-like disturbances associated with inflammatory changes in brain regions involved in spatial memory and anxiety. © 2017 Taylor & Francis Group, LLC. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_02699052_v32_n1_p113_Broussard
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Animal model anxiety chronic traumatic encephalopathy mild traumatic brain injury spatial memory glial fibrillary acidic protein animal cell animal experiment animal model animal tissue anxiety Article astrocytosis behavior cell activation controlled study corpus callosum dentate gyrus hippocampus immunohistochemistry locomotion male microglia motor performance mouse nervous system inflammation nonhuman open field test spatial memory time spent in open arms traumatic brain injury animal animal behavior anxiety astrocyte brain brain concussion complication encephalitis gliosis maze test memory disorder motor activity pathology physiology psychology recurrent disease spatial memory Animals Anxiety Astrocytes Behavior, Animal Brain Brain Concussion Encephalitis Gliosis Male Maze Learning Memory Disorders Mice Microglia Models, Animal Motor Activity Recurrence Spatial Memory
spellingShingle	Animal model anxiety chronic traumatic encephalopathy mild traumatic brain injury spatial memory glial fibrillary acidic protein animal cell animal experiment animal model animal tissue anxiety Article astrocytosis behavior cell activation controlled study corpus callosum dentate gyrus hippocampus immunohistochemistry locomotion male microglia motor performance mouse nervous system inflammation nonhuman open field test spatial memory time spent in open arms traumatic brain injury animal animal behavior anxiety astrocyte brain brain concussion complication encephalitis gliosis maze test memory disorder motor activity pathology physiology psychology recurrent disease spatial memory Animals Anxiety Astrocytes Behavior, Animal Brain Brain Concussion Encephalitis Gliosis Male Maze Learning Memory Disorders Mice Microglia Models, Animal Motor Activity Recurrence Spatial Memory Broussard, J.I. Acion, L. De Jesús-Cortés, H. Yin, T. Britt, J.K. Salas, R. Costa-Mattioli, M. Robertson, C. Pieper, A.A. Arciniegas, D.B. Jorge, R. Repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice
topic_facet	Animal model anxiety chronic traumatic encephalopathy mild traumatic brain injury spatial memory glial fibrillary acidic protein animal cell animal experiment animal model animal tissue anxiety Article astrocytosis behavior cell activation controlled study corpus callosum dentate gyrus hippocampus immunohistochemistry locomotion male microglia motor performance mouse nervous system inflammation nonhuman open field test spatial memory time spent in open arms traumatic brain injury animal animal behavior anxiety astrocyte brain brain concussion complication encephalitis gliosis maze test memory disorder motor activity pathology physiology psychology recurrent disease spatial memory Animals Anxiety Astrocytes Behavior, Animal Brain Brain Concussion Encephalitis Gliosis Male Maze Learning Memory Disorders Mice Microglia Models, Animal Motor Activity Recurrence Spatial Memory
description	Primary Objective: Repeated traumatic brain injuries (rmTBI) are frequently associated with debilitating neuropsychiatric conditions such as cognitive impairment, mood disorders, and post-traumatic stress disorder. We tested the hypothesis that repeated mild traumatic brain injury impairs spatial memory and enhances anxiety-like behaviour. Research Design: We used a between groups design using single (smTBI) or repeated (rmTBI) controlled cranial closed skull impacts to mice, compared to a control group. Methods and Procedures: We assessed the effects of smTBI and rmTBI using measures of motor performance (Rotarod Test [RT]), anxiety-like behaviour (Elevated Plus Maze [EPM] and Open Field [OF] tests), and spatial memory (Morris Water Maze [MWM]) within 12 days of the final injury. In separate groups of mice, astrocytosis and microglial activation were assessed 24 hours after the final injury using GFAP and IBA-1 immunohistochemistry. Main Outcomes and Results: RmTBI impaired spatial memory in the MWM and increased anxiety-like behaviour in the EPM and OFT. In addition, rmTBI elevated GFAP and IBA-1 immunohistochemistry throughout the mouse brain. RmTBI produced astrocytosis and microglial activation, and elicited impaired spatial memory and anxiety-like behaviour. Conclusions: rmTBI produces acute cognitive and anxiety-like disturbances associated with inflammatory changes in brain regions involved in spatial memory and anxiety. © 2017 Taylor & Francis Group, LLC.
format	JOUR
author	Broussard, J.I. Acion, L. De Jesús-Cortés, H. Yin, T. Britt, J.K. Salas, R. Costa-Mattioli, M. Robertson, C. Pieper, A.A. Arciniegas, D.B. Jorge, R.
author_facet	Broussard, J.I. Acion, L. De Jesús-Cortés, H. Yin, T. Britt, J.K. Salas, R. Costa-Mattioli, M. Robertson, C. Pieper, A.A. Arciniegas, D.B. Jorge, R.
author_sort	Broussard, J.I.
title	Repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice
title_short	Repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice
title_full	Repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice
title_fullStr	Repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice
title_full_unstemmed	Repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice
title_sort	repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice
url	http://hdl.handle.net/20.500.12110/paper_02699052_v32_n1_p113_Broussard
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Repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice

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